Abstract
Coumarin-3-carboxylic acids were obtained in high yields with excellent purity from ortho-hydroxybenzaldehydes and Meldrum's acid after a 2 h reflux in ethanol. The less reactive ketones were first reacted with alcoholic ammonia to form ketimines, which were then condensed with Meldrum's acid to generate 4-alkylcoumarin-3-carboxylic acids in moderate yields.
Original language | English (US) |
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Pages (from-to) | 1755-1758 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 44 |
Issue number | 9 |
DOIs | |
State | Published - Feb 24 2003 |
Keywords
- Coumarin-3-carboxylic acids
- Knoevenagel condensation
- Meldrum's acid
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery