A convenient and flexible approach for introducing linkers on bifunctional chelating agents

Martin Studer, Claude F. Meares

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The synthesis of a protected bifunctional analog of ethylenediaminetetraacetic acid (EDTA) is described. The molecule contains an aminobenzyl moiety that allows the easy attachment of the chelating agent to a wide variety of groups. Examples of reaction with the C-termini of two peptides are given. In the following paper, the two peptides are used to study the enzymatic cleavage of metal chelates from a monoclonal antibody. 1043-1802/92/2903-0420$03.00/0

Original languageEnglish (US)
Pages (from-to)420-423
Number of pages4
JournalBioconjugate Chemistry
Volume3
Issue number5
StatePublished - 1992

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Clinical Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

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