A controlled trial of stimulant medication in children with the fragile X syndrome

Randi J Hagerman, M. A. Murphy, M. D. Wittenberger

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Attentional deficits and hyperactivity frequently are major problems for fra(X) boys. This study evaluated the effectiveness of 2 stimulant medications, methylphenidate and dextroamphetamine compared to placebo in 15 children (13 males, 2 females) with the fra(X) syndrome. A double-blind crossover design was used with outcome measures which included parent and teacher behavior checklists, a controlled observation period, continuous performance tasks and an actometer measure of movement. When the children were treated with methylphenidate only, improvement was seen in socialization skills and attention span according to teacher checklists. Ten children were clinically considered responders and treatment was continued after the study was completed.

Original languageEnglish (US)
Pages (from-to)377-392
Number of pages16
JournalAmerican Journal of Medical Genetics
Volume30
Issue number1-2
StatePublished - 1988
Externally publishedYes

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Fragile X Syndrome
Methylphenidate
Checklist
Dextroamphetamine
Socialization
Task Performance and Analysis
Cross-Over Studies
Placebos
Observation
Outcome Assessment (Health Care)
Therapeutics

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

A controlled trial of stimulant medication in children with the fragile X syndrome. / Hagerman, Randi J; Murphy, M. A.; Wittenberger, M. D.

In: American Journal of Medical Genetics, Vol. 30, No. 1-2, 1988, p. 377-392.

Research output: Contribution to journalArticle

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