A comprehensive transcriptional map of primate brain development

Trygve E. Bakken, Jeremy A. Miller, Song Lin Ding, Susan M. Sunkin, Kimberly A. Smith, Lydia Ng, Aaron Szafer, Rachel A. Dalley, Joshua J. Royall, Tracy Lemon, Sheila Shapouri, Kaylynn Aiona, James Arnold, Jeffrey L. Bennett, Darren Bertagnolli, Kristopher Bickley, Andrew Boe, Krissy Brouner, Stephanie Butler, Emi ByrnesShiella Caldejon, Anita Carey, Shelby Cate, Mike Chapin, Jefferey Chen, Nick Dee, Tsega Desta, Tim A. Dolbeare, Nadia Dotson, Amanda Ebbert, Erich Fulfs, Garrett Gee, Terri L. Gilbert, Jeff Goldy, Lindsey Gourley, Ben Gregor, Guangyu Gu, Jon Hall, Zeb Haradon, David R. Haynor, Nika Hejazinia, Anna Hoerder-Suabedissen, Robert Howard, Jay Jochim, Marty Kinnunen, Ali Kriedberg, Chihchau L. Kuan, Christopher Lau, Chang Kyu Lee, Felix Lee, Lon Luong, Naveed Mastan, Ryan May, Jose Melchor, Nerick Mosqueda, Erika Mott, Kiet Ngo, Julie Nyhus, Aaron Oldre, Eric Olson, Jody Parente, Patrick D. Parker, Sheana Parry, Julie Pendergraft, Lydia Potekhina, Melissa Reding, Zackery L. Riley, Tyson Roberts, Brandon Rogers, Kate Roll, David Rosen, David Sandman, Melaine Sarreal, Nadiya Shapovalova, Shu Shi, Nathan Sjoquist, Andy J. Sodt, Robbie Townsend, Lissette Velasquez, Udi Wagley, Wayne B. Wakeman, Cassandra White, Crissa Bennett, Jennifer Wu, Rob Young, Brian L. Youngstrom, Paul Wohnoutka, Richard A. Gibbs, Jeffrey Rogers, John G. Hohmann, Michael J. Hawrylycz, Robert F. Hevner, Zoltán Molnár, John W. Phillips, Chinh Dang, Allan R. Jones, David G Amaral, Amy Bernard, Ed S. Lein

Research output: Contribution to journalArticle

136 Scopus citations

Abstract

The transcriptional underpinnings of brain development remain poorly understood, particularly in humans and closely related non-human primates. We describe a high-resolution transcriptional atlas of rhesus monkey (Macaca mulatta) brain development that combines dense temporal sampling of prenatal and postnatal periods with fine anatomical division of cortical and subcortical regions associated with human neuropsychiatric disease. Gene expression changes more rapidly before birth, both in progenitor cells and maturing neurons. Cortical layers and areas acquire adult-like molecular profiles surprisingly late in postnatal development. Disparate cell populations exhibit distinct developmental timing of gene expression, but also unexpected synchrony of processes underlying neural circuit construction including cell projection and adhesion. Candidate risk genes for neurodevelopmental disorders including primary microcephaly, autism spectrum disorder, intellectual disability, and schizophrenia show disease-specific spatiotemporal enrichment within developing neocortex. Human developmental expression trajectories are more similar to monkey than rodent, although approximately 9% of genes show human-specific regulation with evidence for prolonged maturation or neoteny compared to monkey.

Original languageEnglish (US)
Pages (from-to)367-375
Number of pages9
JournalNature
Volume535
Issue number7612
DOIs
StatePublished - Jul 13 2016

ASJC Scopus subject areas

  • Medicine(all)
  • General

Fingerprint Dive into the research topics of 'A comprehensive transcriptional map of primate brain development'. Together they form a unique fingerprint.

Cite this