A comprehensive evaluation of serum autoantibodies in primary biliary cirrhosis

Nancy Agmon-Levin, Yinon Shapira, Carlo Selmi, Ori Barzilai, Maya Ram, Martine Szyper-Kravitz, Sara Sella, Bat sheva Porat Katz, Pierre Youinou, Yves Renaudineau, Bruno Larida, Pietro Invernizzi, M. Eric Gershwin, Yehuda Shoenfeld

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Abstract

In primary biliary cirrhosis (PBC) serum markers other than anti-mitochondrial antibodies (AMA) are promising in terms of disease severity and comorbidities, as well represented by anti-nuclear antibodies (ANA). The aim of the present study was thus to evaluate the prevalence and clinical significance of a large profile of serum autoantibodies in PBC sera. We utilized 69 sera from European patients with PBC (including 20 AMA-negative) and 297 sera from geographically and sex-matched healthy controls. All sera were tested for the presence of ANA and autoantibodies associated with thrombophilia, vasculitis, and gastrointestinal disease. Autoantibodies other than AMA were detected in 53/69 (76%) PBC sera vs. 105/297 (35%) among controls. The prevalence of ANA (targeting dsDNA, Sm, chromatin, ribosomal-P, RNP, SmRNP, SSA, SSB, and centromere) and thrombophilia-associated autoantibodies (i.e. anti-β2GPI, phosphatydilserine, prothrombin) was common among patients with PBC. When clinical features were compared, the presence of anti-prothrombin IgM was associated with a worse prognosis as represented by a higher Mayo score. We demonstrate an increased prevalence of ANA and thrombophilia-associated autoantibodies in PBC sera and an association between the latter autoantibodies and PBC stage. The role of thrombophilia-associated antibodies will warrant further studies, based in particular on the incidence of portal hypertension at early stages of PBC.

Original languageEnglish (US)
Pages (from-to)55-58
Number of pages4
JournalJournal of Autoimmunity
Volume34
Issue number1
DOIs
StatePublished - Feb 2010

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Biliary Liver Cirrhosis
Autoantibodies
Anti-Idiotypic Antibodies
Thrombophilia
Serum
Prothrombin
Centromere
Gastrointestinal Diseases
Portal Hypertension
Vasculitis
Chromatin
Comorbidity
Biomarkers
Antibodies
Incidence

Keywords

  • Anti-nuclear antibodies
  • Anti-phospholipid antibodies
  • Anti-prothrombin antibodies
  • Autoimmune cholangitis
  • Primary biliary cirrhosis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Agmon-Levin, N., Shapira, Y., Selmi, C., Barzilai, O., Ram, M., Szyper-Kravitz, M., ... Shoenfeld, Y. (2010). A comprehensive evaluation of serum autoantibodies in primary biliary cirrhosis. Journal of Autoimmunity, 34(1), 55-58. https://doi.org/10.1016/j.jaut.2009.08.009

A comprehensive evaluation of serum autoantibodies in primary biliary cirrhosis. / Agmon-Levin, Nancy; Shapira, Yinon; Selmi, Carlo; Barzilai, Ori; Ram, Maya; Szyper-Kravitz, Martine; Sella, Sara; Katz, Bat sheva Porat; Youinou, Pierre; Renaudineau, Yves; Larida, Bruno; Invernizzi, Pietro; Gershwin, M. Eric; Shoenfeld, Yehuda.

In: Journal of Autoimmunity, Vol. 34, No. 1, 02.2010, p. 55-58.

Research output: Contribution to journalArticle

Agmon-Levin, N, Shapira, Y, Selmi, C, Barzilai, O, Ram, M, Szyper-Kravitz, M, Sella, S, Katz, BSP, Youinou, P, Renaudineau, Y, Larida, B, Invernizzi, P, Gershwin, ME & Shoenfeld, Y 2010, 'A comprehensive evaluation of serum autoantibodies in primary biliary cirrhosis', Journal of Autoimmunity, vol. 34, no. 1, pp. 55-58. https://doi.org/10.1016/j.jaut.2009.08.009
Agmon-Levin N, Shapira Y, Selmi C, Barzilai O, Ram M, Szyper-Kravitz M et al. A comprehensive evaluation of serum autoantibodies in primary biliary cirrhosis. Journal of Autoimmunity. 2010 Feb;34(1):55-58. https://doi.org/10.1016/j.jaut.2009.08.009
Agmon-Levin, Nancy ; Shapira, Yinon ; Selmi, Carlo ; Barzilai, Ori ; Ram, Maya ; Szyper-Kravitz, Martine ; Sella, Sara ; Katz, Bat sheva Porat ; Youinou, Pierre ; Renaudineau, Yves ; Larida, Bruno ; Invernizzi, Pietro ; Gershwin, M. Eric ; Shoenfeld, Yehuda. / A comprehensive evaluation of serum autoantibodies in primary biliary cirrhosis. In: Journal of Autoimmunity. 2010 ; Vol. 34, No. 1. pp. 55-58.
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AU - Sella, Sara

AU - Katz, Bat sheva Porat

AU - Youinou, Pierre

AU - Renaudineau, Yves

AU - Larida, Bruno

AU - Invernizzi, Pietro

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