A compendium of the mouse mammary tumor biologist: From the initial observations in the house mouse to the development of genetically engineered mice

Robert Cardiff, Nicholas Kenney

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

For over a century mouse mammary tumor biology and the associated mouse mammary tumor virus (MMTV) have served as the foundation for experimental cancer research in general and in particular experimental breast cancer research. Spontaneous mouse mammary tumors were the basis for studies of the natural history of neoplasia oncogenic viruses host responses endocrinology and neoplastic progression. However lacking formal proof of a human mammary tumor virus the preeminence of the mouse model faded in the 1980s. Since the late 1980s genetically engineered mice (GEM) have proven extremely useful for studying breast cancer and have become the animal model for human breast cancer. Hundreds of mouse models of human breast cancer have been developed since the first demonstration in 1984. The GEM have attracted a newgeneration of molecular and cellular biologists eager to apply their skill sets to these surrogates of the human disease. Newcomers often enter the field without an appreciation of the origins of mouse mammary tumor biology and the basis for many of the prevailing concepts. Our purpose in writing this compendium is to extend an "olive branch" while simultaneously deepen the knowledge of the novice mouse mammary tumor biologist as they journey into a field rich in pathology and genetics spanning several centuries.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalCold Spring Harbor perspectives in biology
Volume3
Issue number6
DOIs
StatePublished - Jun 1 2011

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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