A compendium of the mouse mammary tumor biologist: From the initial observations in the house mouse to the development of genetically engineered mice

Robert Cardiff, Nicholas Kenney

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

For over a century mouse mammary tumor biology and the associated mouse mammary tumor virus (MMTV) have served as the foundation for experimental cancer research in general and in particular experimental breast cancer research. Spontaneous mouse mammary tumors were the basis for studies of the natural history of neoplasia oncogenic viruses host responses endocrinology and neoplastic progression. However lacking formal proof of a human mammary tumor virus the preeminence of the mouse model faded in the 1980s. Since the late 1980s genetically engineered mice (GEM) have proven extremely useful for studying breast cancer and have become the animal model for human breast cancer. Hundreds of mouse models of human breast cancer have been developed since the first demonstration in 1984. The GEM have attracted a newgeneration of molecular and cellular biologists eager to apply their skill sets to these surrogates of the human disease. Newcomers often enter the field without an appreciation of the origins of mouse mammary tumor biology and the basis for many of the prevailing concepts. Our purpose in writing this compendium is to extend an "olive branch" while simultaneously deepen the knowledge of the novice mouse mammary tumor biologist as they journey into a field rich in pathology and genetics spanning several centuries.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalCold Spring Harbor perspectives in biology
Volume3
Issue number6
DOIs
StatePublished - Jun 1 2011

Fingerprint

Tumors
Breast Neoplasms
Mouse mammary tumor virus
Viruses
Oncogenic viruses
Endocrinology
Pathology
Oncogenic Viruses
Animals
Olea
Demonstrations
Research
Neoplasms
Animal Models

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

@article{95dfa67d54d141339ee46d212c02ecd2,
title = "A compendium of the mouse mammary tumor biologist: From the initial observations in the house mouse to the development of genetically engineered mice",
abstract = "For over a century mouse mammary tumor biology and the associated mouse mammary tumor virus (MMTV) have served as the foundation for experimental cancer research in general and in particular experimental breast cancer research. Spontaneous mouse mammary tumors were the basis for studies of the natural history of neoplasia oncogenic viruses host responses endocrinology and neoplastic progression. However lacking formal proof of a human mammary tumor virus the preeminence of the mouse model faded in the 1980s. Since the late 1980s genetically engineered mice (GEM) have proven extremely useful for studying breast cancer and have become the animal model for human breast cancer. Hundreds of mouse models of human breast cancer have been developed since the first demonstration in 1984. The GEM have attracted a newgeneration of molecular and cellular biologists eager to apply their skill sets to these surrogates of the human disease. Newcomers often enter the field without an appreciation of the origins of mouse mammary tumor biology and the basis for many of the prevailing concepts. Our purpose in writing this compendium is to extend an {"}olive branch{"} while simultaneously deepen the knowledge of the novice mouse mammary tumor biologist as they journey into a field rich in pathology and genetics spanning several centuries.",
author = "Robert Cardiff and Nicholas Kenney",
year = "2011",
month = "6",
day = "1",
doi = "10.1101/cshperspect.a003111",
language = "English (US)",
volume = "3",
pages = "1--12",
journal = "Cold Spring Harbor perspectives in biology",
issn = "1943-0264",
publisher = "Cold Spring Harbor Laboratory Press",
number = "6",

}

TY - JOUR

T1 - A compendium of the mouse mammary tumor biologist

T2 - From the initial observations in the house mouse to the development of genetically engineered mice

AU - Cardiff, Robert

AU - Kenney, Nicholas

PY - 2011/6/1

Y1 - 2011/6/1

N2 - For over a century mouse mammary tumor biology and the associated mouse mammary tumor virus (MMTV) have served as the foundation for experimental cancer research in general and in particular experimental breast cancer research. Spontaneous mouse mammary tumors were the basis for studies of the natural history of neoplasia oncogenic viruses host responses endocrinology and neoplastic progression. However lacking formal proof of a human mammary tumor virus the preeminence of the mouse model faded in the 1980s. Since the late 1980s genetically engineered mice (GEM) have proven extremely useful for studying breast cancer and have become the animal model for human breast cancer. Hundreds of mouse models of human breast cancer have been developed since the first demonstration in 1984. The GEM have attracted a newgeneration of molecular and cellular biologists eager to apply their skill sets to these surrogates of the human disease. Newcomers often enter the field without an appreciation of the origins of mouse mammary tumor biology and the basis for many of the prevailing concepts. Our purpose in writing this compendium is to extend an "olive branch" while simultaneously deepen the knowledge of the novice mouse mammary tumor biologist as they journey into a field rich in pathology and genetics spanning several centuries.

AB - For over a century mouse mammary tumor biology and the associated mouse mammary tumor virus (MMTV) have served as the foundation for experimental cancer research in general and in particular experimental breast cancer research. Spontaneous mouse mammary tumors were the basis for studies of the natural history of neoplasia oncogenic viruses host responses endocrinology and neoplastic progression. However lacking formal proof of a human mammary tumor virus the preeminence of the mouse model faded in the 1980s. Since the late 1980s genetically engineered mice (GEM) have proven extremely useful for studying breast cancer and have become the animal model for human breast cancer. Hundreds of mouse models of human breast cancer have been developed since the first demonstration in 1984. The GEM have attracted a newgeneration of molecular and cellular biologists eager to apply their skill sets to these surrogates of the human disease. Newcomers often enter the field without an appreciation of the origins of mouse mammary tumor biology and the basis for many of the prevailing concepts. Our purpose in writing this compendium is to extend an "olive branch" while simultaneously deepen the knowledge of the novice mouse mammary tumor biologist as they journey into a field rich in pathology and genetics spanning several centuries.

UR - http://www.scopus.com/inward/record.url?scp=84858030498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858030498&partnerID=8YFLogxK

U2 - 10.1101/cshperspect.a003111

DO - 10.1101/cshperspect.a003111

M3 - Article

C2 - 20961975

AN - SCOPUS:84858030498

VL - 3

SP - 1

EP - 12

JO - Cold Spring Harbor perspectives in biology

JF - Cold Spring Harbor perspectives in biology

SN - 1943-0264

IS - 6

ER -