A Comparison of Xylazine–Diazepam–Ketamine and Xylazine–Guaifenesin–Ketamine in Equine Anesthesia

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Abstract

After sedation with xylazine (0.3 mg/kg intravenously [IV]), anesthesia was induced in six healthy horses with ketamine (2.0 mg/kg IV) and guaifenesin (100 mg/kg IV), diazepam (0.05 mg/kg IV), or diazepam (0.10 mg/kg IV). Anesthesia was maintained with halothane for 30 minutes. Heart rate, respiratory rate, direct arterial blood pressure, arterial blood gas, and pH measurements were made before, and at set intervals after, induction of anesthesia. Quality and characteristics of induction and recovery were evaluated objectively by an independent observer unaware of the protocol used. There were no significant differences among the three protocols from pre‐induction values for arterial blood pressure, blood gas values, and pH. There was significantly greater ataxia at induction with the use of guaifenesin. The nature of induction, transition to and recovery from general anesthesia were comparable between guaifenesin and the higher dose of diazepam. Because of movements and difficulty with intubation, the lower dose of diazepam was considered unsatisfactory. It was concluded that diazepam (0.10 mg/kg) could be substituted for guaifenesin (100 mg/kg) to produce comparable quality of anesthesia in horses.

Original languageEnglish (US)
Pages (from-to)468-474
Number of pages7
JournalVeterinary Surgery
Volume19
Issue number6
DOIs
StatePublished - Jan 1 1990

Fingerprint

Guaifenesin
diazepam
guaifenesin
Diazepam
Horses
anesthesia
Anesthesia
horses
blood gases
blood pressure
Arterial Pressure
Gases
Xylazine
blood pH
xylazine
Ketamine
halothane
sedation
ketamine
Halothane

ASJC Scopus subject areas

  • veterinary(all)

Cite this

A Comparison of Xylazine–Diazepam–Ketamine and Xylazine–Guaifenesin–Ketamine in Equine Anesthesia. / BROCK, N.; Hildebrand, Susan.

In: Veterinary Surgery, Vol. 19, No. 6, 01.01.1990, p. 468-474.

Research output: Contribution to journalArticle

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