A comparison of the effects of an alpha-agonist, an anti-muscarinic agent and placebo on intranasal histamine challenge in allergic rhinitis

M. A. Birchall, J. C. Henderson, N. B. Pride, R. W. Fuller

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Autonomic receptors play a part in the physiology and pathology of the nasal mucosa. The effect of an α-agonist and an anti-muscarinic agent on histamine-challenge was examined on patients with perennial allergic rhinitis. Nine patients received saline, oxitropium bromide 0.075%, or xylometazoline hydrochloride 0.1% in a double-blind fashion. Sequential challenge with increasing doses of histamine were given and resistance changes, sneezes and volume and content of secretion measured. Histamine challenge produced dose-related increases in nasal resistance (P < 0.0001), lavage fluid volume (P < 0.01) and total protein (P < 0.01). Following xylometazoline, histamine produced little increase in resistance compared with saline and oxitropium bromide (P < 0.0001). The latter reduced the dose-related increase in resistance (P < 0.01) and nasal lavage fluid volume (P = 0.0007) and total protein (P = 0.023) seen with saline. These results confirm the importance of α-adrenergic and muscarinic receptors in the human nasal mucosa and suggest mechanisms of action for these drugs in perennial allergic rhinitis.

Original languageEnglish (US)
Pages (from-to)212-217
Number of pages6
JournalClinical Otolaryngology and Allied Sciences
Volume21
Issue number3
StatePublished - 1996
Externally publishedYes

Keywords

  • Nasal challenge
  • Oxitropium
  • Rhinitis
  • Xylometazoline

ASJC Scopus subject areas

  • Otorhinolaryngology

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