A comparison of prophylactic ondansetron and droperidol for strabismus repair in adults

E. A. Doe, Mary A O'Hara, P. Jones, S. Brown

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Purpose. To determine whether any differences exist between ondansetron and droperidol in the relief of nausea and vomiting in adults undergoing strabismus surgery. Methods. Twenty adult patients undergoing strabismus surgery were prospectively randomized into either IV droperidol or ondansetron treatment intraoperatively. Nausea and sedation levels were rated by patients immediately postoperatively, in the same day surgery step down unit, and at 24 hours postoperatively. Other dependent variables included: episodes of emesis, time to release from the post anesthesia care unit (PACU), time to discharge, incidence of headaches, and anxiety levels. Differences in nausea and sedation levels were tested with Chi square statistics; differences in time to discharge were tested with a pooled t-test. Results. The study population consisted of predominantly Caucasian (75%), male (65%) strabismus patients with an average age of 30 years. Eight patients received ondansetron and twelve received droperidol interoperatively. There were fewer episodes of emesis among patients treated with ondansetron (14%) vs droperidol (25%). Time to release from the PACU was less among patients treated with Ondansetron (p<0.05). No significant differences in sedation levels, headaches, anxiety, or time to discharge were detected. Conclusions. In adult stabismus surgery there appears to be no clear difference in the effectiveness of intraoperative ondansetron and droperidol in the prevention of postoperative nausea.

Original languageEnglish (US)
JournalInvestigative Ophthalmology and Visual Science
Issue number3
StatePublished - Feb 15 1996
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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