A comparison of cognitive structure in schizophrenia patients and healthy controls using confirmatory factor analysis

Dwight Dickinson, John D Ragland, Monica E. Calkins, James M. Gold, Ruben C. Gur

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

There is evidence that cognitive task performance breaks down into the same broad domains in schizophrenia as in healthy populations. However, this does not mean that the domains are independent of one another or that the interrelationships among domains are the same between groups. We used confirmatory factor analysis (CFA) to compare the latent structure of a broad neuropsychological battery in schizophrenia patients (n = 148) and healthy controls (n = 157). Main analyses examined the fit of a hierarchical six-factor model, in which associations among the factors were assumed to reflect their strong shared relationship to a general cognitive ability factor. The model incorporated the factors of verbal comprehension, perceptual organization, verbal memory, spatial memory, processing speed, and executive/working memory. The hierarchical model provided a good overall fit to data from both groups. However multiple groups CFA revealed significant differences in factor loadings between groups, reflecting a more generalized latent structure of cognitive ability in schizophrenia. This was also evident in higher bivariate correlations among cognitive domain composite scores calculated from the observed test data. Cognitive ability, as reflected in test performance, appears to be more unitary in schizophrenia than in healthy subjects. This finding may have measurement and treatment implications.

Original languageEnglish (US)
Pages (from-to)20-29
Number of pages10
JournalSchizophrenia Research
Volume85
Issue number1-3
DOIs
StatePublished - Jul 2006
Externally publishedYes

Fingerprint

Statistical Factor Analysis
Aptitude
Schizophrenia
Task Performance and Analysis
Short-Term Memory
Healthy Volunteers
Population
Therapeutics

Keywords

  • Cognition
  • Confirmatory factor analysis
  • Neuropsychology
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

A comparison of cognitive structure in schizophrenia patients and healthy controls using confirmatory factor analysis. / Dickinson, Dwight; Ragland, John D; Calkins, Monica E.; Gold, James M.; Gur, Ruben C.

In: Schizophrenia Research, Vol. 85, No. 1-3, 07.2006, p. 20-29.

Research output: Contribution to journalArticle

Dickinson, Dwight ; Ragland, John D ; Calkins, Monica E. ; Gold, James M. ; Gur, Ruben C. / A comparison of cognitive structure in schizophrenia patients and healthy controls using confirmatory factor analysis. In: Schizophrenia Research. 2006 ; Vol. 85, No. 1-3. pp. 20-29.
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