Abstract
Cartilage exhibits nonlinear viscoelastic behaviour. Various models have been proposed to explain cartilage stress relaxation, but it is unclear whether explicit modelling of fluid flow in unconfined compression is needed. This study compared Fung's quasi-linear viscoelastic (QLV) model with a stretched-exponential model of cartilage stress relaxation and examined each of these models both alone and in combination with a fluid-flow model in unconfined compression. Cartilage explants were harvested from bovine calf patellofemoral joints and equilibrated in tissue culture for 5 days before stress-relaxation testing in unconfined compression at 5% nominal strain. The stretched exponential models fit as well as the QLV models. Furthermore, the average stretched exponential relaxation time determined by this model lies within the range of experimentally measured relaxation times for extracted proteoglycan aggregates, consistent with the hypothesis that the stretched exponential model represents polymeric mechanisms of cartilage viscoelasticity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 565-576 |
| Number of pages | 12 |
| Journal | Computer Methods in Biomechanics and Biomedical Engineering |
| Volume | 16 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2013 |
Fingerprint
Keywords
- cartilage
- flow-independent viscoelasticity
- osteoarthritis
- polymer dynamics
- stress relaxation
ASJC Scopus subject areas
- Bioengineering
- Biomedical Engineering
- Computer Science Applications
- Human-Computer Interaction
Cite this
A comparison of cartilage stress-relaxation models in unconfined compression : QLV and stretched exponential in combination with fluid flow. / June, Ronald K.; Fyhrie, David P.
In: Computer Methods in Biomechanics and Biomedical Engineering, Vol. 16, No. 5, 05.2013, p. 565-576.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A comparison of cartilage stress-relaxation models in unconfined compression
T2 - QLV and stretched exponential in combination with fluid flow
AU - June, Ronald K.
AU - Fyhrie, David P
PY - 2013/5
Y1 - 2013/5
N2 - Cartilage exhibits nonlinear viscoelastic behaviour. Various models have been proposed to explain cartilage stress relaxation, but it is unclear whether explicit modelling of fluid flow in unconfined compression is needed. This study compared Fung's quasi-linear viscoelastic (QLV) model with a stretched-exponential model of cartilage stress relaxation and examined each of these models both alone and in combination with a fluid-flow model in unconfined compression. Cartilage explants were harvested from bovine calf patellofemoral joints and equilibrated in tissue culture for 5 days before stress-relaxation testing in unconfined compression at 5% nominal strain. The stretched exponential models fit as well as the QLV models. Furthermore, the average stretched exponential relaxation time determined by this model lies within the range of experimentally measured relaxation times for extracted proteoglycan aggregates, consistent with the hypothesis that the stretched exponential model represents polymeric mechanisms of cartilage viscoelasticity.
AB - Cartilage exhibits nonlinear viscoelastic behaviour. Various models have been proposed to explain cartilage stress relaxation, but it is unclear whether explicit modelling of fluid flow in unconfined compression is needed. This study compared Fung's quasi-linear viscoelastic (QLV) model with a stretched-exponential model of cartilage stress relaxation and examined each of these models both alone and in combination with a fluid-flow model in unconfined compression. Cartilage explants were harvested from bovine calf patellofemoral joints and equilibrated in tissue culture for 5 days before stress-relaxation testing in unconfined compression at 5% nominal strain. The stretched exponential models fit as well as the QLV models. Furthermore, the average stretched exponential relaxation time determined by this model lies within the range of experimentally measured relaxation times for extracted proteoglycan aggregates, consistent with the hypothesis that the stretched exponential model represents polymeric mechanisms of cartilage viscoelasticity.
KW - cartilage
KW - flow-independent viscoelasticity
KW - osteoarthritis
KW - polymer dynamics
KW - stress relaxation
UR - http://www.scopus.com/inward/record.url?scp=84878159481&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878159481&partnerID=8YFLogxK
U2 - 10.1080/10255842.2011.629612
DO - 10.1080/10255842.2011.629612
M3 - Article
C2 - 22149471
AN - SCOPUS:84878159481
VL - 16
SP - 565
EP - 576
JO - Computer Methods in Biomechanics and Biomedical Engineering
JF - Computer Methods in Biomechanics and Biomedical Engineering
SN - 1025-5842
IS - 5
ER -