Abstract
Volatile anaesthetic agents potentiate neuromuscular blocking agents and retard their rate of reversal. We hypothesised that there was a difference in the rate of reversal of rocuronium-induced neuromuscular blockade based on the selection of inhalation agent. Thirty-eight patients undergoing elective surgical procedures received either sevoflurane or isoflurane, by random allocation. Neuromuscular blockade was induced using rocuronium 0.6 mg/kg-1 followed by continuous intravenous infusion to maintain 90% suppression of the single twitch response. Upon completion of surgery, the rocuronium infusion was discontinued, neostigmine 50 μg/kg-1 and glycopyrrolate 10 μg/kg-1 were administered. Times from reversal to T1 = 25, 50 and 60% and train-of-four ratio = 0.6 were recorded. The mean (SD) times to train-of-four ratio = 0.6 in the isoflurane and sevoflurane groups were 327 (132) and 351 (127) s, respectively. The mean (SD) times to single twitch response T1 = 25, 50 and 60% in the isoflurane group were 81 (33), 161 (59) and 245 (84) s, respectively, and in the sevoflurance group were 95 (35), 203 (88) and 252 (127) s, respectively. It is concluded that reversal of rocuronium-induced neuromuscular blockade is similar during isoflurane and sevoflurane anaesthesia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 960-964 |
| Number of pages | 5 |
| Journal | Anaesthesia |
| Volume | 55 |
| Issue number | 10 |
| DOIs | |
| State | Published - 2000 |
| Externally published | Yes |
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Keywords
- Anaesthetic agents: isoflurane; sevoflurane
- Neuromuscular blocking agent: rocuronium
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Cite this
A comparison of antagonism of rocuronium-induced neuromuscular blockade during sevoflurane and isoflurane anaesthesia. / Sutcliffe, D. G.; Murphy, C. M.; Maslow, A.; Uppington, Jeffrey; Shorten, G. D.
In: Anaesthesia, Vol. 55, No. 10, 2000, p. 960-964.Research output: Contribution to journal › Article
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TY - JOUR
T1 - A comparison of antagonism of rocuronium-induced neuromuscular blockade during sevoflurane and isoflurane anaesthesia
AU - Sutcliffe, D. G.
AU - Murphy, C. M.
AU - Maslow, A.
AU - Uppington, Jeffrey
AU - Shorten, G. D.
PY - 2000
Y1 - 2000
N2 - Volatile anaesthetic agents potentiate neuromuscular blocking agents and retard their rate of reversal. We hypothesised that there was a difference in the rate of reversal of rocuronium-induced neuromuscular blockade based on the selection of inhalation agent. Thirty-eight patients undergoing elective surgical procedures received either sevoflurane or isoflurane, by random allocation. Neuromuscular blockade was induced using rocuronium 0.6 mg/kg-1 followed by continuous intravenous infusion to maintain 90% suppression of the single twitch response. Upon completion of surgery, the rocuronium infusion was discontinued, neostigmine 50 μg/kg-1 and glycopyrrolate 10 μg/kg-1 were administered. Times from reversal to T1 = 25, 50 and 60% and train-of-four ratio = 0.6 were recorded. The mean (SD) times to train-of-four ratio = 0.6 in the isoflurane and sevoflurane groups were 327 (132) and 351 (127) s, respectively. The mean (SD) times to single twitch response T1 = 25, 50 and 60% in the isoflurane group were 81 (33), 161 (59) and 245 (84) s, respectively, and in the sevoflurance group were 95 (35), 203 (88) and 252 (127) s, respectively. It is concluded that reversal of rocuronium-induced neuromuscular blockade is similar during isoflurane and sevoflurane anaesthesia.
AB - Volatile anaesthetic agents potentiate neuromuscular blocking agents and retard their rate of reversal. We hypothesised that there was a difference in the rate of reversal of rocuronium-induced neuromuscular blockade based on the selection of inhalation agent. Thirty-eight patients undergoing elective surgical procedures received either sevoflurane or isoflurane, by random allocation. Neuromuscular blockade was induced using rocuronium 0.6 mg/kg-1 followed by continuous intravenous infusion to maintain 90% suppression of the single twitch response. Upon completion of surgery, the rocuronium infusion was discontinued, neostigmine 50 μg/kg-1 and glycopyrrolate 10 μg/kg-1 were administered. Times from reversal to T1 = 25, 50 and 60% and train-of-four ratio = 0.6 were recorded. The mean (SD) times to train-of-four ratio = 0.6 in the isoflurane and sevoflurane groups were 327 (132) and 351 (127) s, respectively. The mean (SD) times to single twitch response T1 = 25, 50 and 60% in the isoflurane group were 81 (33), 161 (59) and 245 (84) s, respectively, and in the sevoflurance group were 95 (35), 203 (88) and 252 (127) s, respectively. It is concluded that reversal of rocuronium-induced neuromuscular blockade is similar during isoflurane and sevoflurane anaesthesia.
KW - Anaesthetic agents: isoflurane; sevoflurane
KW - Neuromuscular blocking agent: rocuronium
UR - http://www.scopus.com/inward/record.url?scp=0033791155&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033791155&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2044.2000.01526.x
DO - 10.1046/j.1365-2044.2000.01526.x
M3 - Article
C2 - 11012490
AN - SCOPUS:0033791155
VL - 55
SP - 960
EP - 964
JO - Anaesthesia
JF - Anaesthesia
SN - 0003-2409
IS - 10
ER -