A comparative gene map of the horse (Equus caballus)

Alexandre R. Caetano, Yow Ling Shiue, Leslie A Lyons, Steven J. O'Brien, Thomas F. Laughlin, Ann T. Bowling, James D. Murray

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

A comparative gene map of the horse genome composed of 127 loci was assembled based on the new assignment of 68 equine type 1 loci and on data published previously. PCR primers based on consensus gene sequences conserved across mammalian species were used to amplify markers for assigning 68 equine type 1 loci to 27 horse synteny groups established previously with a horse-mouse somatic cell hybrid panel (SCHP, UC Davis). This increased the number of coding genes mapped to the horse genome by over 2-fold and allowed refinements of the comparative mapping data available for this species. In conjunction with 57 previous assignments of type 1 loci to the horse genome map, these data have allowed us to confirm the assignment of 24 equine synteny groups to their respective chromosomes, to provisionally assign nine synteny groups to chromosomes, and to further refine the genetic composition established with Zoo-FISH of two horse chromosomes. The equine type 1 markers developed in this study provide an important resource for the future development of the horse linkage and physical genome maps.

Original languageEnglish (US)
Pages (from-to)1239-1249
Number of pages11
JournalGenome Research
Volume9
Issue number12
DOIs
StatePublished - Dec 1999
Externally publishedYes

Fingerprint

Horses
Genes
Synteny
Genome
Chromosomes
Hybrid Cells
Consensus Sequence
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Genetics

Cite this

Caetano, A. R., Shiue, Y. L., Lyons, L. A., O'Brien, S. J., Laughlin, T. F., Bowling, A. T., & Murray, J. D. (1999). A comparative gene map of the horse (Equus caballus). Genome Research, 9(12), 1239-1249. https://doi.org/10.1101/gr.9.12.1239

A comparative gene map of the horse (Equus caballus). / Caetano, Alexandre R.; Shiue, Yow Ling; Lyons, Leslie A; O'Brien, Steven J.; Laughlin, Thomas F.; Bowling, Ann T.; Murray, James D.

In: Genome Research, Vol. 9, No. 12, 12.1999, p. 1239-1249.

Research output: Contribution to journalArticle

Caetano, AR, Shiue, YL, Lyons, LA, O'Brien, SJ, Laughlin, TF, Bowling, AT & Murray, JD 1999, 'A comparative gene map of the horse (Equus caballus)', Genome Research, vol. 9, no. 12, pp. 1239-1249. https://doi.org/10.1101/gr.9.12.1239
Caetano AR, Shiue YL, Lyons LA, O'Brien SJ, Laughlin TF, Bowling AT et al. A comparative gene map of the horse (Equus caballus). Genome Research. 1999 Dec;9(12):1239-1249. https://doi.org/10.1101/gr.9.12.1239
Caetano, Alexandre R. ; Shiue, Yow Ling ; Lyons, Leslie A ; O'Brien, Steven J. ; Laughlin, Thomas F. ; Bowling, Ann T. ; Murray, James D. / A comparative gene map of the horse (Equus caballus). In: Genome Research. 1999 ; Vol. 9, No. 12. pp. 1239-1249.
@article{12b3f9b2b4e643d889c901c14d4fde0b,
title = "A comparative gene map of the horse (Equus caballus)",
abstract = "A comparative gene map of the horse genome composed of 127 loci was assembled based on the new assignment of 68 equine type 1 loci and on data published previously. PCR primers based on consensus gene sequences conserved across mammalian species were used to amplify markers for assigning 68 equine type 1 loci to 27 horse synteny groups established previously with a horse-mouse somatic cell hybrid panel (SCHP, UC Davis). This increased the number of coding genes mapped to the horse genome by over 2-fold and allowed refinements of the comparative mapping data available for this species. In conjunction with 57 previous assignments of type 1 loci to the horse genome map, these data have allowed us to confirm the assignment of 24 equine synteny groups to their respective chromosomes, to provisionally assign nine synteny groups to chromosomes, and to further refine the genetic composition established with Zoo-FISH of two horse chromosomes. The equine type 1 markers developed in this study provide an important resource for the future development of the horse linkage and physical genome maps.",
author = "Caetano, {Alexandre R.} and Shiue, {Yow Ling} and Lyons, {Leslie A} and O'Brien, {Steven J.} and Laughlin, {Thomas F.} and Bowling, {Ann T.} and Murray, {James D.}",
year = "1999",
month = "12",
doi = "10.1101/gr.9.12.1239",
language = "English (US)",
volume = "9",
pages = "1239--1249",
journal = "Genome Research",
issn = "1088-9051",
publisher = "Cold Spring Harbor Laboratory Press",
number = "12",

}

TY - JOUR

T1 - A comparative gene map of the horse (Equus caballus)

AU - Caetano, Alexandre R.

AU - Shiue, Yow Ling

AU - Lyons, Leslie A

AU - O'Brien, Steven J.

AU - Laughlin, Thomas F.

AU - Bowling, Ann T.

AU - Murray, James D.

PY - 1999/12

Y1 - 1999/12

N2 - A comparative gene map of the horse genome composed of 127 loci was assembled based on the new assignment of 68 equine type 1 loci and on data published previously. PCR primers based on consensus gene sequences conserved across mammalian species were used to amplify markers for assigning 68 equine type 1 loci to 27 horse synteny groups established previously with a horse-mouse somatic cell hybrid panel (SCHP, UC Davis). This increased the number of coding genes mapped to the horse genome by over 2-fold and allowed refinements of the comparative mapping data available for this species. In conjunction with 57 previous assignments of type 1 loci to the horse genome map, these data have allowed us to confirm the assignment of 24 equine synteny groups to their respective chromosomes, to provisionally assign nine synteny groups to chromosomes, and to further refine the genetic composition established with Zoo-FISH of two horse chromosomes. The equine type 1 markers developed in this study provide an important resource for the future development of the horse linkage and physical genome maps.

AB - A comparative gene map of the horse genome composed of 127 loci was assembled based on the new assignment of 68 equine type 1 loci and on data published previously. PCR primers based on consensus gene sequences conserved across mammalian species were used to amplify markers for assigning 68 equine type 1 loci to 27 horse synteny groups established previously with a horse-mouse somatic cell hybrid panel (SCHP, UC Davis). This increased the number of coding genes mapped to the horse genome by over 2-fold and allowed refinements of the comparative mapping data available for this species. In conjunction with 57 previous assignments of type 1 loci to the horse genome map, these data have allowed us to confirm the assignment of 24 equine synteny groups to their respective chromosomes, to provisionally assign nine synteny groups to chromosomes, and to further refine the genetic composition established with Zoo-FISH of two horse chromosomes. The equine type 1 markers developed in this study provide an important resource for the future development of the horse linkage and physical genome maps.

UR - http://www.scopus.com/inward/record.url?scp=0033427346&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033427346&partnerID=8YFLogxK

U2 - 10.1101/gr.9.12.1239

DO - 10.1101/gr.9.12.1239

M3 - Article

VL - 9

SP - 1239

EP - 1249

JO - Genome Research

JF - Genome Research

SN - 1088-9051

IS - 12

ER -