A cohort study of the association between serum immunoglobulin G concentration and preweaning health, growth, and survival in Holstein calves

P. Pithua, Sharif S Aly

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The association between serum IgG concentration and preweaning health performance in Holstein calves were evaluated in a prospective cohort study design framework. Post colostral blood samples were collected from 561 calves and serum IgG concentrations were quantitated using a single radial immunodiffusion assay. Preweaning treatments for diarrhea, pneumonia, omphalitis and frequency of antibiotic therapy plus calf death events were recorded until calves were weaned at approximately 60 d of age. Logistic regression modeling was used to evaluate the association between failure of passive transfer of immunity (FPT, serum IgG < 10g/L) and risk of diarrhea, pneumonia, omphalitis, frequency of antibiotic therapy and death. Calves with FPT were twice as likely to suffer from scours (OR = 2.34; 95% CI = 1.54 to 3.56), otitis media (OR = 2.62; 95% CI = 1.28 to 5.35) and be treated with antibiotics (OR = 2.20; 95% CI = 1.55 to 3.12) during the preweaning period as herd mates that had adequate passive transfer of immunity (APT, serum IgG ≥ 10 g/L). Although FPT status was not associated with pneumonia, omphalitis, and preweaning mortality risks in this study, mean preweaning daily live weight gain (kg/d) was significantly lower for calves with FPT relative to calves with APT.

Original languageEnglish (US)
Pages (from-to)77-84
Number of pages8
JournalInternational Journal of Applied Research in Veterinary Medicine
Volume11
Issue number1
StatePublished - 2013

Fingerprint

immunoglobulin G
blood serum
cohort studies
Cohort Studies
Holstein
Immunoglobulin G
calves
Pneumonia
Passive Immunization
Health
Growth
Anti-Bacterial Agents
Serum
Diarrhea
pneumonia
diarrhea
antibiotics
Immunodiffusion
Otitis Media
Weight Gain

Keywords

  • Diarrhea
  • Failure of passive transfer of immunity
  • Frequency of antibiotic therapy and death
  • Omphalitis
  • Pneumonia

ASJC Scopus subject areas

  • veterinary(all)

Cite this

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abstract = "The association between serum IgG concentration and preweaning health performance in Holstein calves were evaluated in a prospective cohort study design framework. Post colostral blood samples were collected from 561 calves and serum IgG concentrations were quantitated using a single radial immunodiffusion assay. Preweaning treatments for diarrhea, pneumonia, omphalitis and frequency of antibiotic therapy plus calf death events were recorded until calves were weaned at approximately 60 d of age. Logistic regression modeling was used to evaluate the association between failure of passive transfer of immunity (FPT, serum IgG < 10g/L) and risk of diarrhea, pneumonia, omphalitis, frequency of antibiotic therapy and death. Calves with FPT were twice as likely to suffer from scours (OR = 2.34; 95{\%} CI = 1.54 to 3.56), otitis media (OR = 2.62; 95{\%} CI = 1.28 to 5.35) and be treated with antibiotics (OR = 2.20; 95{\%} CI = 1.55 to 3.12) during the preweaning period as herd mates that had adequate passive transfer of immunity (APT, serum IgG ≥ 10 g/L). Although FPT status was not associated with pneumonia, omphalitis, and preweaning mortality risks in this study, mean preweaning daily live weight gain (kg/d) was significantly lower for calves with FPT relative to calves with APT.",
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