TY - JOUR
T1 - A cohort study of developmental polychlorinated biphenyl (PCB) exposure in relation to post-vaccination antibody response at 6-months of age
AU - Jusko, Todd A.
AU - De Roos, Anneclaire J.
AU - Schwartz, Stephen M.
AU - Paige Lawrence, B.
AU - Palkovicova, Lubica
AU - Nemessanyi, Tomas
AU - Drobna, Beata
AU - Fabisikova, Anna
AU - Kocan, Anton
AU - Sonneborn, Dean
AU - Jahnova, Eva
AU - Kavanagh, Terrance J.
AU - Trnovec, Tomas
AU - Hertz-Picciotto, Irva
PY - 2010/5
Y1 - 2010/5
N2 - Background: Extensive experimental data in animals indicate that exposure to polychlorinated biphenyls (PCBs) during pregnancy leads to changes in offspring immune function during the postnatal period. Whether developmental PCB exposure influences immunologic development in humans has received little study. Methods: The study population was 384 mother-infant pairs recruited from two districts of eastern Slovakia for whom prospectively collected maternal, cord, and 6-month infant blood specimens were available. Several PCB congeners were measured in maternal, cord, and 6-month infant sera by high-resolution gas chromatography with electron capture detection. Concentrations of IgG-specific anti-haemophilus influenzae type b, tetanus toxoid, and diphtheria toxoid were assayed in 6-month infant sera using ELISA methods. Multiple linear regression was used to estimate the relation between maternal, cord, and 6-month infant PCB concentrations and the antibody concentrations evaluated at 6-months of age. Results: Overall, there was little evidence of an association between infant antibody concentrations and PCB measures during the pre- and early postnatal period. In addition, our results did not show specificity in terms of associations limited to a particular developmental period (e.g. pre- vs. postnatal), a particular antibody, or a particular PCB congener. Conclusions: At the PCB concentrations measured in this cohort, which are high relative to most human populations today, we did not detect an association between maternal or early postnatal PCB exposure and specific antibody responses at 6-months of age.
AB - Background: Extensive experimental data in animals indicate that exposure to polychlorinated biphenyls (PCBs) during pregnancy leads to changes in offspring immune function during the postnatal period. Whether developmental PCB exposure influences immunologic development in humans has received little study. Methods: The study population was 384 mother-infant pairs recruited from two districts of eastern Slovakia for whom prospectively collected maternal, cord, and 6-month infant blood specimens were available. Several PCB congeners were measured in maternal, cord, and 6-month infant sera by high-resolution gas chromatography with electron capture detection. Concentrations of IgG-specific anti-haemophilus influenzae type b, tetanus toxoid, and diphtheria toxoid were assayed in 6-month infant sera using ELISA methods. Multiple linear regression was used to estimate the relation between maternal, cord, and 6-month infant PCB concentrations and the antibody concentrations evaluated at 6-months of age. Results: Overall, there was little evidence of an association between infant antibody concentrations and PCB measures during the pre- and early postnatal period. In addition, our results did not show specificity in terms of associations limited to a particular developmental period (e.g. pre- vs. postnatal), a particular antibody, or a particular PCB congener. Conclusions: At the PCB concentrations measured in this cohort, which are high relative to most human populations today, we did not detect an association between maternal or early postnatal PCB exposure and specific antibody responses at 6-months of age.
KW - B-cell
KW - Biomarker
KW - Directed acyclic graph
KW - Epidemiology
KW - Infant
KW - Roma
KW - Slovakia
UR - http://www.scopus.com/inward/record.url?scp=77950951760&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950951760&partnerID=8YFLogxK
U2 - 10.1016/j.envres.2010.02.010
DO - 10.1016/j.envres.2010.02.010
M3 - Article
C2 - 20378105
AN - SCOPUS:77950951760
VL - 110
SP - 388
EP - 395
JO - Environmental Research
JF - Environmental Research
SN - 0013-9351
IS - 4
ER -