A cohort study of developmental polychlorinated biphenyl (PCB) exposure in relation to post-vaccination antibody response at 6-months of age

Todd A. Jusko, Anneclaire J. De Roos, Stephen M. Schwartz, B. Paige Lawrence, Lubica Palkovicova, Tomas Nemessanyi, Beata Drobna, Anna Fabisikova, Anton Kocan, Dean Sonneborn, Eva Jahnova, Terrance J. Kavanagh, Tomas Trnovec, Irva Hertz-Picciotto

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Background: Extensive experimental data in animals indicate that exposure to polychlorinated biphenyls (PCBs) during pregnancy leads to changes in offspring immune function during the postnatal period. Whether developmental PCB exposure influences immunologic development in humans has received little study. Methods: The study population was 384 mother-infant pairs recruited from two districts of eastern Slovakia for whom prospectively collected maternal, cord, and 6-month infant blood specimens were available. Several PCB congeners were measured in maternal, cord, and 6-month infant sera by high-resolution gas chromatography with electron capture detection. Concentrations of IgG-specific anti-haemophilus influenzae type b, tetanus toxoid, and diphtheria toxoid were assayed in 6-month infant sera using ELISA methods. Multiple linear regression was used to estimate the relation between maternal, cord, and 6-month infant PCB concentrations and the antibody concentrations evaluated at 6-months of age. Results: Overall, there was little evidence of an association between infant antibody concentrations and PCB measures during the pre- and early postnatal period. In addition, our results did not show specificity in terms of associations limited to a particular developmental period (e.g. pre- vs. postnatal), a particular antibody, or a particular PCB congener. Conclusions: At the PCB concentrations measured in this cohort, which are high relative to most human populations today, we did not detect an association between maternal or early postnatal PCB exposure and specific antibody responses at 6-months of age.

Original languageEnglish (US)
Pages (from-to)388-395
Number of pages8
JournalEnvironmental Research
Volume110
Issue number4
DOIs
StatePublished - May 2010

Keywords

  • B-cell
  • Biomarker
  • Directed acyclic graph
  • Epidemiology
  • Infant
  • Roma
  • Slovakia

ASJC Scopus subject areas

  • Environmental Science(all)
  • Biochemistry

Fingerprint Dive into the research topics of 'A cohort study of developmental polychlorinated biphenyl (PCB) exposure in relation to post-vaccination antibody response at 6-months of age'. Together they form a unique fingerprint.

  • Cite this

    Jusko, T. A., De Roos, A. J., Schwartz, S. M., Paige Lawrence, B., Palkovicova, L., Nemessanyi, T., Drobna, B., Fabisikova, A., Kocan, A., Sonneborn, D., Jahnova, E., Kavanagh, T. J., Trnovec, T., & Hertz-Picciotto, I. (2010). A cohort study of developmental polychlorinated biphenyl (PCB) exposure in relation to post-vaccination antibody response at 6-months of age. Environmental Research, 110(4), 388-395. https://doi.org/10.1016/j.envres.2010.02.010