A clonal complete remission in a patient with acute nonlymphocytic leukemia originating in a multipotent stem cell

R. J. Jacobson, M. J. Temple, J. W. Singer, W. Raskind, Jerry S Powell, P. J. Fialkow

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Abstract

We describe a patient with acute nonlymphocytic leukemia in whom assays of glucose-6-phosphate dehydrogenase activity and cytogenetic studies showed the disease to be clonal and karyotypically abnormal on presentation. When the patient entered a chemotherapy-induced complete clinical remission, the marrow progenitors and blood cells had normal morphologic features and a normal karyotype but were still derived from a single clone.

Original languageEnglish (US)
Pages (from-to)1513-1517
Number of pages5
JournalNew England Journal of Medicine
Volume310
Issue number23
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Jacobson, R. J., Temple, M. J., Singer, J. W., Raskind, W., Powell, J. S., & Fialkow, P. J. (1984). A clonal complete remission in a patient with acute nonlymphocytic leukemia originating in a multipotent stem cell. New England Journal of Medicine, 310(23), 1513-1517.