A clonal complete remission in a patient with acute nonlymphocytic leukemia originating in a multipotent stem cell

R. J. Jacobson; M. J. Temple; J. W. Singer; W. Raskind; Jerry S Powell; P. J. Fialkow

A clonal complete remission in a patient with acute nonlymphocytic leukemia originating in a multipotent stem cell

R. J. Jacobson, M. J. Temple, J. W. Singer, W. Raskind, Jerry S Powell, P. J. Fialkow

Research output: Contribution to journal › Article › peer-review

Abstract

We describe a patient with acute nonlymphocytic leukemia in whom assays of glucose-6-phosphate dehydrogenase activity and cytogenetic studies showed the disease to be clonal and karyotypically abnormal on presentation. When the patient entered a chemotherapy-induced complete clinical remission, the marrow progenitors and blood cells had normal morphologic features and a normal karyotype but were still derived from a single clone.

Original language	English (US)
Pages (from-to)	1513-1517
Number of pages	5
Journal	New England Journal of Medicine
Volume	310
Issue number	23
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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Cite this

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title = "A clonal complete remission in a patient with acute nonlymphocytic leukemia originating in a multipotent stem cell",

abstract = "We describe a patient with acute nonlymphocytic leukemia in whom assays of glucose-6-phosphate dehydrogenase activity and cytogenetic studies showed the disease to be clonal and karyotypically abnormal on presentation. When the patient entered a chemotherapy-induced complete clinical remission, the marrow progenitors and blood cells had normal morphologic features and a normal karyotype but were still derived from a single clone.",

author = "Jacobson, {R. J.} and Temple, {M. J.} and Singer, {J. W.} and W. Raskind and Powell, {Jerry S} and Fialkow, {P. J.}",

year = "1984",

language = "English (US)",

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pages = "1513--1517",

journal = "New England Journal of Medicine",

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AU - Jacobson, R. J.

AU - Temple, M. J.

AU - Singer, J. W.

AU - Raskind, W.

AU - Powell, Jerry S

AU - Fialkow, P. J.

PY - 1984

Y1 - 1984

N2 - We describe a patient with acute nonlymphocytic leukemia in whom assays of glucose-6-phosphate dehydrogenase activity and cytogenetic studies showed the disease to be clonal and karyotypically abnormal on presentation. When the patient entered a chemotherapy-induced complete clinical remission, the marrow progenitors and blood cells had normal morphologic features and a normal karyotype but were still derived from a single clone.

AB - We describe a patient with acute nonlymphocytic leukemia in whom assays of glucose-6-phosphate dehydrogenase activity and cytogenetic studies showed the disease to be clonal and karyotypically abnormal on presentation. When the patient entered a chemotherapy-induced complete clinical remission, the marrow progenitors and blood cells had normal morphologic features and a normal karyotype but were still derived from a single clone.

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M3 - Article

C2 - 6717542

AN - SCOPUS:0021631106

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