A clear look at the neuroimmunology of multiple sclerosis and beyond

Carlo Selmi, Eilhard Mix, Uwe K. Zettl

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The term neuroimmunology was first coined to refer to a generic involvement of the immune system in the pathogenesis of neurological diseases, particularly of the central nervous system. Since then, the neuroimmunology spectrum has steadily grown and currently spans from classical autoimmune diseases of the central and peripheral nervous systems to previously unsuspected conditions such as autism spectrum disorders or chronic fatigue syndrome. Multiple sclerosis remains the predominant entity in terms of research efforts and social pressure as well as a good model of organ-specific autoimmune disease with limited therapeutic options. While the fast-pace genome-wide association studies reported a number of genes to be significantly associated with multiple sclerosis, these currently explain only a minor part of disease susceptibility. Further, clinicians are continuously challenged with the clinical classifications of immune-mediated or autoimmune central and peripheral conditions and with other pragmatic questions such as the roles of vaccination and physical therapy. For these reasons the present collection of Autoimmunity Reviews is timely as it will address these major issues related to neuroimmunology.

Original languageEnglish (US)
Pages (from-to)159-162
Number of pages4
JournalAutoimmunity Reviews
Volume11
Issue number3
DOIs
StatePublished - Jan 2012

Fingerprint

Multiple Sclerosis
Autoimmune Diseases of the Nervous System
Chronic Fatigue Syndrome
Genome-Wide Association Study
Central Nervous System Diseases
Disease Susceptibility
Peripheral Nervous System
Autoimmunity
Autoimmune Diseases
Immune System
Vaccination
Central Nervous System
Pressure
Therapeutics
Research
Genes
Autism Spectrum Disorder

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

A clear look at the neuroimmunology of multiple sclerosis and beyond. / Selmi, Carlo; Mix, Eilhard; Zettl, Uwe K.

In: Autoimmunity Reviews, Vol. 11, No. 3, 01.2012, p. 159-162.

Research output: Contribution to journalArticle

Selmi, Carlo ; Mix, Eilhard ; Zettl, Uwe K. / A clear look at the neuroimmunology of multiple sclerosis and beyond. In: Autoimmunity Reviews. 2012 ; Vol. 11, No. 3. pp. 159-162.
@article{11a9f78e34d543d7ba79b1ba9675fe92,
title = "A clear look at the neuroimmunology of multiple sclerosis and beyond",
abstract = "The term neuroimmunology was first coined to refer to a generic involvement of the immune system in the pathogenesis of neurological diseases, particularly of the central nervous system. Since then, the neuroimmunology spectrum has steadily grown and currently spans from classical autoimmune diseases of the central and peripheral nervous systems to previously unsuspected conditions such as autism spectrum disorders or chronic fatigue syndrome. Multiple sclerosis remains the predominant entity in terms of research efforts and social pressure as well as a good model of organ-specific autoimmune disease with limited therapeutic options. While the fast-pace genome-wide association studies reported a number of genes to be significantly associated with multiple sclerosis, these currently explain only a minor part of disease susceptibility. Further, clinicians are continuously challenged with the clinical classifications of immune-mediated or autoimmune central and peripheral conditions and with other pragmatic questions such as the roles of vaccination and physical therapy. For these reasons the present collection of Autoimmunity Reviews is timely as it will address these major issues related to neuroimmunology.",
author = "Carlo Selmi and Eilhard Mix and Zettl, {Uwe K.}",
year = "2012",
month = "1",
doi = "10.1016/j.autrev.2011.05.006",
language = "English (US)",
volume = "11",
pages = "159--162",
journal = "Autoimmunity Reviews",
issn = "1568-9972",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - A clear look at the neuroimmunology of multiple sclerosis and beyond

AU - Selmi, Carlo

AU - Mix, Eilhard

AU - Zettl, Uwe K.

PY - 2012/1

Y1 - 2012/1

N2 - The term neuroimmunology was first coined to refer to a generic involvement of the immune system in the pathogenesis of neurological diseases, particularly of the central nervous system. Since then, the neuroimmunology spectrum has steadily grown and currently spans from classical autoimmune diseases of the central and peripheral nervous systems to previously unsuspected conditions such as autism spectrum disorders or chronic fatigue syndrome. Multiple sclerosis remains the predominant entity in terms of research efforts and social pressure as well as a good model of organ-specific autoimmune disease with limited therapeutic options. While the fast-pace genome-wide association studies reported a number of genes to be significantly associated with multiple sclerosis, these currently explain only a minor part of disease susceptibility. Further, clinicians are continuously challenged with the clinical classifications of immune-mediated or autoimmune central and peripheral conditions and with other pragmatic questions such as the roles of vaccination and physical therapy. For these reasons the present collection of Autoimmunity Reviews is timely as it will address these major issues related to neuroimmunology.

AB - The term neuroimmunology was first coined to refer to a generic involvement of the immune system in the pathogenesis of neurological diseases, particularly of the central nervous system. Since then, the neuroimmunology spectrum has steadily grown and currently spans from classical autoimmune diseases of the central and peripheral nervous systems to previously unsuspected conditions such as autism spectrum disorders or chronic fatigue syndrome. Multiple sclerosis remains the predominant entity in terms of research efforts and social pressure as well as a good model of organ-specific autoimmune disease with limited therapeutic options. While the fast-pace genome-wide association studies reported a number of genes to be significantly associated with multiple sclerosis, these currently explain only a minor part of disease susceptibility. Further, clinicians are continuously challenged with the clinical classifications of immune-mediated or autoimmune central and peripheral conditions and with other pragmatic questions such as the roles of vaccination and physical therapy. For these reasons the present collection of Autoimmunity Reviews is timely as it will address these major issues related to neuroimmunology.

UR - http://www.scopus.com/inward/record.url?scp=84855922988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855922988&partnerID=8YFLogxK

U2 - 10.1016/j.autrev.2011.05.006

DO - 10.1016/j.autrev.2011.05.006

M3 - Article

VL - 11

SP - 159

EP - 162

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

SN - 1568-9972

IS - 3

ER -