A class of supported membranes: Formation of fluid phospholipid bilayers on photonic band gap colloidal crystals

Adrian M. Brozell, Michelle A. Muha, Babak Sanii, Atul N. Parikh

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

We report the formation of a new class of supported membranes consisting of a fluid phospholipid bilayer coupled directly to a broadly tunable colloidal crystal with a well-defined photonic band gap. For nanoscale colloidal crystals exhibiting a band gap at the optical frequencies, substrate-induced vesicle fusion gives rise to a surface bilayer riding onto the crystal surface. The bilayer is two-dimensionally continuous, spanning multiple beads with lateral mobilities which reflect the coupling between the bilayer topography and the curvature of the supporting colloidal surface. In contrast, the spreading of vesicles on micrometer scale colloidal crystals results in the formation of bilayers wrapping individual colloidal beads. We show that simple UV photolithography of colloidal crystals produces binary patterns of crystal wettabilities, photonic stopbands, and corresponding patterns of lipid mono- and bilayer morphologies. We envisage that these approaches will be exploitable for the development of optical transduction assays and microarrays for many membrane-mediated processes, including transport and receptor-ligand interactions.

Original languageEnglish (US)
Pages (from-to)62-63
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number1
DOIs
StatePublished - Jan 11 2006

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Optics and Photonics
Photonic band gap
Phospholipids
Wettability
Membranes
Crystals
Fluids
Lipid Bilayers
Ligands
Photolithography
Microarrays
Photonics
Topography
Lipids
Wetting
Monolayers
Assays
Energy gap
Fusion reactions
Substrates

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

A class of supported membranes : Formation of fluid phospholipid bilayers on photonic band gap colloidal crystals. / Brozell, Adrian M.; Muha, Michelle A.; Sanii, Babak; Parikh, Atul N.

In: Journal of the American Chemical Society, Vol. 128, No. 1, 11.01.2006, p. 62-63.

Research output: Contribution to journalArticle

Brozell, Adrian M. ; Muha, Michelle A. ; Sanii, Babak ; Parikh, Atul N. / A class of supported membranes : Formation of fluid phospholipid bilayers on photonic band gap colloidal crystals. In: Journal of the American Chemical Society. 2006 ; Vol. 128, No. 1. pp. 62-63.
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