A chemoselective, one-pot transformation of aldehydes to nitriles

Sébastien Laulhé, Sadakatali S. Gori, Michael H. Nantz

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

This paper describes a procedure for direct conversion of aldehydes to nitriles using O-(diphenylphosphinyl)hydroxylamine (DPPH). Aldehydes are smoothly transformed to their corresponding nitriles by heating with DPPH in toluene. The reaction can be accomplished in the presence of alcohol, ketone, ester, or amine functionality.

Original languageEnglish (US)
Pages (from-to)9334-9337
Number of pages4
JournalJournal of Organic Chemistry
Volume77
Issue number20
DOIs
StatePublished - Oct 19 2012
Externally publishedYes

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Nitriles
Hydroxylamine
Aldehydes
Toluene
Ketones
Amines
Esters
Alcohols
Heating

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

A chemoselective, one-pot transformation of aldehydes to nitriles. / Laulhé, Sébastien; Gori, Sadakatali S.; Nantz, Michael H.

In: Journal of Organic Chemistry, Vol. 77, No. 20, 19.10.2012, p. 9334-9337.

Research output: Contribution to journalArticle

Laulhé, Sébastien ; Gori, Sadakatali S. ; Nantz, Michael H. / A chemoselective, one-pot transformation of aldehydes to nitriles. In: Journal of Organic Chemistry. 2012 ; Vol. 77, No. 20. pp. 9334-9337.
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