A chemoselective, one-pot transformation of aldehydes to nitriles

Sébastien Laulhé, Sadakatali S. Gori, Michael H. Nantz

Research output: Contribution to journalArticle

27 Scopus citations


This paper describes a procedure for direct conversion of aldehydes to nitriles using O-(diphenylphosphinyl)hydroxylamine (DPPH). Aldehydes are smoothly transformed to their corresponding nitriles by heating with DPPH in toluene. The reaction can be accomplished in the presence of alcohol, ketone, ester, or amine functionality.

Original languageEnglish (US)
Pages (from-to)9334-9337
Number of pages4
JournalJournal of Organic Chemistry
Issue number20
Publication statusPublished - Oct 19 2012
Externally publishedYes


ASJC Scopus subject areas

  • Organic Chemistry

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