A chemoselective, one-pot transformation of aldehydes to nitriles

Sébastien Laulhé, Sadakatali S. Gori, Michael H. Nantz

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


This paper describes a procedure for direct conversion of aldehydes to nitriles using O-(diphenylphosphinyl)hydroxylamine (DPPH). Aldehydes are smoothly transformed to their corresponding nitriles by heating with DPPH in toluene. The reaction can be accomplished in the presence of alcohol, ketone, ester, or amine functionality.

Original languageEnglish (US)
Pages (from-to)9334-9337
Number of pages4
JournalJournal of Organic Chemistry
Issue number20
StatePublished - Oct 19 2012
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry


Dive into the research topics of 'A chemoselective, one-pot transformation of aldehydes to nitriles'. Together they form a unique fingerprint.

Cite this