A chemoselective, one-pot transformation of aldehydes to nitriles

Sébastien Laulhé, Sadakatali S. Gori, Michael H. Nantz

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Abstract

This paper describes a procedure for direct conversion of aldehydes to nitriles using O-(diphenylphosphinyl)hydroxylamine (DPPH). Aldehydes are smoothly transformed to their corresponding nitriles by heating with DPPH in toluene. The reaction can be accomplished in the presence of alcohol, ketone, ester, or amine functionality.

Original languageEnglish (US)
Pages (from-to)9334-9337
Number of pages4
JournalJournal of Organic Chemistry
Volume77
Issue number20
DOIs
Publication statusPublished - Oct 19 2012
Externally publishedYes

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ASJC Scopus subject areas

  • Organic Chemistry

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