A case of SRY-positive 38,XY true hermaphroditism (XY sex reversal) in a cat

D. H. Schlafer, B. Valentine, G. Fahnestock, L. Froenicke, Robert A Grahn, Leslie A Lyons, V. N. Meyers-Wallen

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Investigation of abnormal sexual development in companion animals can allow for the elimination of inherited disorders from breeding populations while contributing to the understanding of the complex process of mammalian sexual development and differentiation. A 1-year-old mixed-breed cat, presented for neutering, was tentatively diagnosed as a male with bilateral cryptorchidism. During surgery, the surgeon identified gonads in an ovarian position and a complete bicornuate uterus. Both testicular and ovarian architecture in the gonads and Mullerian and Wolffian duct derivatives were identified histologically. The karyotype was that of a normal male (38,XY), and no causative mutation was identified in the feline SRY coding sequence amplified from genomic DNA. All features of the case were compatible with a diagnosis of SRY-positive 38,XY sex reversal, true hermaphrodite phenotype. To the authors' knowledge, this is the first report of this disorder in a domestic cat.

Original languageEnglish (US)
Pages (from-to)817-822
Number of pages6
JournalVeterinary Pathology
Volume48
Issue number4
DOIs
StatePublished - Jul 2011

Fingerprint

Ovotesticular Disorders of Sex Development
hermaphroditism
Sexual Development
sex reversal
sexual development
Gonads
Elimination Disorders
Cats
Wolffian Ducts
cats
Mullerian Ducts
Sex Differentiation
Cryptorchidism
gonads
Pets
Felidae
Karyotype
cryptorchidism
Uterus
Breeding

Keywords

  • feline SRY
  • ovotestes
  • XY disorder of sexual development
  • XY sex reversal
  • XY true hermaphrodite

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Schlafer, D. H., Valentine, B., Fahnestock, G., Froenicke, L., Grahn, R. A., Lyons, L. A., & Meyers-Wallen, V. N. (2011). A case of SRY-positive 38,XY true hermaphroditism (XY sex reversal) in a cat. Veterinary Pathology, 48(4), 817-822. https://doi.org/10.1177/0300985810382093

A case of SRY-positive 38,XY true hermaphroditism (XY sex reversal) in a cat. / Schlafer, D. H.; Valentine, B.; Fahnestock, G.; Froenicke, L.; Grahn, Robert A; Lyons, Leslie A; Meyers-Wallen, V. N.

In: Veterinary Pathology, Vol. 48, No. 4, 07.2011, p. 817-822.

Research output: Contribution to journalArticle

Schlafer, DH, Valentine, B, Fahnestock, G, Froenicke, L, Grahn, RA, Lyons, LA & Meyers-Wallen, VN 2011, 'A case of SRY-positive 38,XY true hermaphroditism (XY sex reversal) in a cat', Veterinary Pathology, vol. 48, no. 4, pp. 817-822. https://doi.org/10.1177/0300985810382093
Schlafer, D. H. ; Valentine, B. ; Fahnestock, G. ; Froenicke, L. ; Grahn, Robert A ; Lyons, Leslie A ; Meyers-Wallen, V. N. / A case of SRY-positive 38,XY true hermaphroditism (XY sex reversal) in a cat. In: Veterinary Pathology. 2011 ; Vol. 48, No. 4. pp. 817-822.
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