A case of SRY-positive 38,XY true hermaphroditism (XY sex reversal) in a cat

D. H. Schlafer, B. Valentine, G. Fahnestock, L. Froenicke, Robert A Grahn, Leslie A Lyons, V. N. Meyers-Wallen

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Investigation of abnormal sexual development in companion animals can allow for the elimination of inherited disorders from breeding populations while contributing to the understanding of the complex process of mammalian sexual development and differentiation. A 1-year-old mixed-breed cat, presented for neutering, was tentatively diagnosed as a male with bilateral cryptorchidism. During surgery, the surgeon identified gonads in an ovarian position and a complete bicornuate uterus. Both testicular and ovarian architecture in the gonads and Mullerian and Wolffian duct derivatives were identified histologically. The karyotype was that of a normal male (38,XY), and no causative mutation was identified in the feline SRY coding sequence amplified from genomic DNA. All features of the case were compatible with a diagnosis of SRY-positive 38,XY sex reversal, true hermaphrodite phenotype. To the authors' knowledge, this is the first report of this disorder in a domestic cat.

Original languageEnglish (US)
Pages (from-to)817-822
Number of pages6
JournalVeterinary Pathology
Issue number4
StatePublished - Jul 2011


  • feline SRY
  • ovotestes
  • XY disorder of sexual development
  • XY sex reversal
  • XY true hermaphrodite

ASJC Scopus subject areas

  • veterinary(all)


Dive into the research topics of 'A case of SRY-positive 38,XY true hermaphroditism (XY sex reversal) in a cat'. Together they form a unique fingerprint.

Cite this