A case of latent primary biliary cirrhosis

Keiji Tsuji, Yasuyuki Watanabe, Hirotaka Kouno, Yasuyuki Aisaka, Toshiyuki Masanaga, Hiroto Ishihara, Masaya Kamiyasu, Toshio Nakanishi, Kazuaki Chayama, Toshimasa Asahara, Ross Coppel, M. Eric Gershwin

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A 53-year-old housewife was the donor when living-related donor liver transplantation (LRLT) was performed in her younger sister (49-year-old) with terminal primary biliary cirrhosis (PBC). The donor's liver histology was diagnostic and compatible with PBC, although she was negative for antimitochondrial antibody (AMA: a specific marker of PBC) by immunofluorescence and had normal liver function tests as well as no symptoms of liver disease. In this patient with latent PBC, AMA was eventually detected by immunoblotting, although it was not detected by ELISA. These findings indicate that a family history of PBC is a risk factor for the development of this disease. Our patient was diagnosed before the advent of any clinical or biochemical indicators and before or at the onset of AMA positivity, so her liver histology revealed the earliest stage of PBC.

Original languageEnglish (US)
Pages (from-to)166-169
Number of pages4
JournalHepatology Research
Volume28
Issue number3
DOIs
StatePublished - Mar 2004

Keywords

  • Antimitochondrial antibody
  • Immunoblotting
  • Primary biliary cirrhosis

ASJC Scopus subject areas

  • Gastroenterology

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    Tsuji, K., Watanabe, Y., Kouno, H., Aisaka, Y., Masanaga, T., Ishihara, H., Kamiyasu, M., Nakanishi, T., Chayama, K., Asahara, T., Coppel, R., & Gershwin, M. E. (2004). A case of latent primary biliary cirrhosis. Hepatology Research, 28(3), 166-169. https://doi.org/10.1016/j.hepres.2003.09.006