A case of Kaposi sarcoma in an immunocompetent, heterosexual Irish man: a discussion of etiology and viral transmission

Aleksandra G. Florek, David Eilers, April W. Armstrong

Research output: Contribution to journalArticle

Abstract

Four types of Kaposi sarcoma (KS) have been described, all of which are caused by human herpesvirus-8 (HHV-8).  The incidence of KS in the United States is highest among HIV-positive homosexual men and elderly men of Eastern European, Jewish, or Mediterranean descent. However, few reports describe KS in HIV-negative, immunocompetent heterosexual men in the United States. HHV-8 is transmitted largely via saliva and close sexual contact, whereas there are only a handful of reports of transmission via blood and blood products. We report a case of an HIV-negative, immunocompetent heterosexual man who acquired KS via blood transfusion. A 77-year-old immunocompetent, monogamously heterosexual, HIV-negative Irish man presented with a biopsy-proven KS lesion on the right thigh. Past surgical history included a coronary artery bypass graft, during which he received a blood transfusion from an unknown donor source.  His ecchymotic KS lesions progressed while on doxycycline, intralesional vinblastine, and topical anti-angiogenic medications.  The patient eventually achieved stabilization of KS lesions with acitretin. Our case report emphasizes the need to characterize the phenotype and transmission route of HHV-8 in heterosexual, immunocompetent patients in geographic regions with low HHV-8 seroprevalence.

Original languageEnglish (US)
JournalDermatology Online Journal
Volume21
Issue number10
StatePublished - Oct 1 2015
Externally publishedYes

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Kaposi's Sarcoma
Heterosexuality
Human Herpesvirus 8
HIV
Blood Transfusion
Acitretin
Vinblastine
Doxycycline
Seroepidemiologic Studies
Thigh
Saliva
Coronary Artery Bypass
History
Tissue Donors
Transplants
Phenotype
Biopsy
Incidence

ASJC Scopus subject areas

  • Dermatology

Cite this

A case of Kaposi sarcoma in an immunocompetent, heterosexual Irish man : a discussion of etiology and viral transmission. / Florek, Aleksandra G.; Eilers, David; Armstrong, April W.

In: Dermatology Online Journal, Vol. 21, No. 10, 01.10.2015.

Research output: Contribution to journalArticle

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