Abstract
Autoimmune-related retinopathy and optic neuropathy (ARRON) syndrome is characterized by visual loss and often the presence of antibodies against retinal or optic nerve antigens in the absence of cancer. Limited success has been reported in treatment of ARRON syndrome with medications that suppress the immune system. In many patients, current strategies are insufficient to control the disease. A 47-year-old woman with progressive visual and hearing loss attributed to ARRON syndrome that was resistant to conventional therapies underwent autologous hematopoietic stemcell transplantation (HSCT). Clinical manifestations appeared to stabilize. This report suggests that autologous HSCT may have a therapeutic role in ARRON syndrome.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 43-49 |
| Number of pages | 7 |
| Journal | Journal of Neuro-Ophthalmology |
| Volume | 29 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 2009 |
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ASJC Scopus subject areas
- Clinical Neurology
- Ophthalmology
Cite this
A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation. / Oyama, Yu; Burt, Richard K.; Thirkill, Charles; Hanna, Eissa; Merrill, Kevin; Keltner, John L.
In: Journal of Neuro-Ophthalmology, Vol. 29, No. 1, 03.2009, p. 43-49.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation
AU - Oyama, Yu
AU - Burt, Richard K.
AU - Thirkill, Charles
AU - Hanna, Eissa
AU - Merrill, Kevin
AU - Keltner, John L
PY - 2009/3
Y1 - 2009/3
N2 - Autoimmune-related retinopathy and optic neuropathy (ARRON) syndrome is characterized by visual loss and often the presence of antibodies against retinal or optic nerve antigens in the absence of cancer. Limited success has been reported in treatment of ARRON syndrome with medications that suppress the immune system. In many patients, current strategies are insufficient to control the disease. A 47-year-old woman with progressive visual and hearing loss attributed to ARRON syndrome that was resistant to conventional therapies underwent autologous hematopoietic stemcell transplantation (HSCT). Clinical manifestations appeared to stabilize. This report suggests that autologous HSCT may have a therapeutic role in ARRON syndrome.
AB - Autoimmune-related retinopathy and optic neuropathy (ARRON) syndrome is characterized by visual loss and often the presence of antibodies against retinal or optic nerve antigens in the absence of cancer. Limited success has been reported in treatment of ARRON syndrome with medications that suppress the immune system. In many patients, current strategies are insufficient to control the disease. A 47-year-old woman with progressive visual and hearing loss attributed to ARRON syndrome that was resistant to conventional therapies underwent autologous hematopoietic stemcell transplantation (HSCT). Clinical manifestations appeared to stabilize. This report suggests that autologous HSCT may have a therapeutic role in ARRON syndrome.
UR - http://www.scopus.com/inward/record.url?scp=68049101346&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68049101346&partnerID=8YFLogxK
U2 - 10.1097/WNO.0b013e318199becf
DO - 10.1097/WNO.0b013e318199becf
M3 - Article
C2 - 19458576
AN - SCOPUS:68049101346
VL - 29
SP - 43
EP - 49
JO - Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
JF - Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
SN - 1070-8022
IS - 1
ER -