A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation

Yu Oyama, Richard K. Burt, Charles Thirkill, Eissa Hanna, Kevin Merrill, John L Keltner

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Autoimmune-related retinopathy and optic neuropathy (ARRON) syndrome is characterized by visual loss and often the presence of antibodies against retinal or optic nerve antigens in the absence of cancer. Limited success has been reported in treatment of ARRON syndrome with medications that suppress the immune system. In many patients, current strategies are insufficient to control the disease. A 47-year-old woman with progressive visual and hearing loss attributed to ARRON syndrome that was resistant to conventional therapies underwent autologous hematopoietic stemcell transplantation (HSCT). Clinical manifestations appeared to stabilize. This report suggests that autologous HSCT may have a therapeutic role in ARRON syndrome.

Original languageEnglish (US)
Pages (from-to)43-49
Number of pages7
JournalJournal of Neuro-Ophthalmology
Volume29
Issue number1
DOIs
StatePublished - Mar 2009

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Optic Nerve Diseases
Hematopoietic Stem Cell Transplantation
Transplantation
Optic Nerve
Hearing Loss
Immune System
Therapeutics
Antigens
Antibodies
Neoplasms

ASJC Scopus subject areas

  • Clinical Neurology
  • Ophthalmology

Cite this

A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation. / Oyama, Yu; Burt, Richard K.; Thirkill, Charles; Hanna, Eissa; Merrill, Kevin; Keltner, John L.

In: Journal of Neuro-Ophthalmology, Vol. 29, No. 1, 03.2009, p. 43-49.

Research output: Contribution to journalArticle

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