A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation

Yu Oyama; Richard K. Burt; Charles Thirkill; Eissa Hanna; Kevin Merrill; John L Keltner

doi:10.1097/WNO.0b013e318199becf

A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation

Yu Oyama, Richard K. Burt, Charles Thirkill, Eissa Hanna, Kevin Merrill, John L Keltner

Ophthalmology and Vision Science

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Autoimmune-related retinopathy and optic neuropathy (ARRON) syndrome is characterized by visual loss and often the presence of antibodies against retinal or optic nerve antigens in the absence of cancer. Limited success has been reported in treatment of ARRON syndrome with medications that suppress the immune system. In many patients, current strategies are insufficient to control the disease. A 47-year-old woman with progressive visual and hearing loss attributed to ARRON syndrome that was resistant to conventional therapies underwent autologous hematopoietic stemcell transplantation (HSCT). Clinical manifestations appeared to stabilize. This report suggests that autologous HSCT may have a therapeutic role in ARRON syndrome.

Original language	English (US)
Pages (from-to)	43-49
Number of pages	7
Journal	Journal of Neuro-Ophthalmology
Volume	29
Issue number	1
DOIs	https://doi.org/10.1097/WNO.0b013e318199becf
State	Published - Mar 2009

ASJC Scopus subject areas

Clinical Neurology
Ophthalmology

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A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation. / Oyama, Yu; Burt, Richard K.; Thirkill, Charles; Hanna, Eissa; Merrill, Kevin; Keltner, John L.

In: Journal of Neuro-Ophthalmology, Vol. 29, No. 1, 03.2009, p. 43-49.

Research output: Contribution to journal › Article › peer-review

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A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation

Abstract

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