A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation

Yu Oyama; Richard K. Burt; Charles Thirkill; Eissa Hanna; Kevin Merrill; John L Keltner

doi:10.1097/WNO.0b013e318199becf

A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation

Yu Oyama, Richard K. Burt, Charles Thirkill, Eissa Hanna, Kevin Merrill, John L Keltner

Ophthalmology and Vision Science

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Autoimmune-related retinopathy and optic neuropathy (ARRON) syndrome is characterized by visual loss and often the presence of antibodies against retinal or optic nerve antigens in the absence of cancer. Limited success has been reported in treatment of ARRON syndrome with medications that suppress the immune system. In many patients, current strategies are insufficient to control the disease. A 47-year-old woman with progressive visual and hearing loss attributed to ARRON syndrome that was resistant to conventional therapies underwent autologous hematopoietic stemcell transplantation (HSCT). Clinical manifestations appeared to stabilize. This report suggests that autologous HSCT may have a therapeutic role in ARRON syndrome.

Original language	English (US)
Pages (from-to)	43-49
Number of pages	7
Journal	Journal of Neuro-Ophthalmology
Volume	29
Issue number	1
DOIs	https://doi.org/10.1097/WNO.0b013e318199becf
State	Published - Mar 2009

ASJC Scopus subject areas

Clinical Neurology
Ophthalmology

Access to Document

10.1097/WNO.0b013e318199becf

Fingerprint Dive into the research topics of 'A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation'. Together they form a unique fingerprint.

Cite this

A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation. / Oyama, Yu; Burt, Richard K.; Thirkill, Charles; Hanna, Eissa; Merrill, Kevin; Keltner, John L.

In: Journal of Neuro-Ophthalmology, Vol. 29, No. 1, 03.2009, p. 43-49.

Research output: Contribution to journal › Article › peer-review

@article{278101e86bf342fdbf8683e0f30966c3,

title = "A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation",

abstract = "Autoimmune-related retinopathy and optic neuropathy (ARRON) syndrome is characterized by visual loss and often the presence of antibodies against retinal or optic nerve antigens in the absence of cancer. Limited success has been reported in treatment of ARRON syndrome with medications that suppress the immune system. In many patients, current strategies are insufficient to control the disease. A 47-year-old woman with progressive visual and hearing loss attributed to ARRON syndrome that was resistant to conventional therapies underwent autologous hematopoietic stemcell transplantation (HSCT). Clinical manifestations appeared to stabilize. This report suggests that autologous HSCT may have a therapeutic role in ARRON syndrome.",

author = "Yu Oyama and Burt, {Richard K.} and Charles Thirkill and Eissa Hanna and Kevin Merrill and Keltner, {John L}",

year = "2009",

month = mar,

doi = "10.1097/WNO.0b013e318199becf",

language = "English (US)",

volume = "29",

pages = "43--49",

journal = "Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society",

issn = "1070-8022",

publisher = "Lippincott Williams and Wilkins",

number = "1",

}

TY - JOUR

T1 - A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation

AU - Oyama, Yu

AU - Burt, Richard K.

AU - Thirkill, Charles

AU - Hanna, Eissa

AU - Merrill, Kevin

AU - Keltner, John L

PY - 2009/3

Y1 - 2009/3

N2 - Autoimmune-related retinopathy and optic neuropathy (ARRON) syndrome is characterized by visual loss and often the presence of antibodies against retinal or optic nerve antigens in the absence of cancer. Limited success has been reported in treatment of ARRON syndrome with medications that suppress the immune system. In many patients, current strategies are insufficient to control the disease. A 47-year-old woman with progressive visual and hearing loss attributed to ARRON syndrome that was resistant to conventional therapies underwent autologous hematopoietic stemcell transplantation (HSCT). Clinical manifestations appeared to stabilize. This report suggests that autologous HSCT may have a therapeutic role in ARRON syndrome.

AB - Autoimmune-related retinopathy and optic neuropathy (ARRON) syndrome is characterized by visual loss and often the presence of antibodies against retinal or optic nerve antigens in the absence of cancer. Limited success has been reported in treatment of ARRON syndrome with medications that suppress the immune system. In many patients, current strategies are insufficient to control the disease. A 47-year-old woman with progressive visual and hearing loss attributed to ARRON syndrome that was resistant to conventional therapies underwent autologous hematopoietic stemcell transplantation (HSCT). Clinical manifestations appeared to stabilize. This report suggests that autologous HSCT may have a therapeutic role in ARRON syndrome.

UR - http://www.scopus.com/inward/record.url?scp=68049101346&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68049101346&partnerID=8YFLogxK

U2 - 10.1097/WNO.0b013e318199becf

DO - 10.1097/WNO.0b013e318199becf

M3 - Article

C2 - 19458576

AN - SCOPUS:68049101346

VL - 29

SP - 43

EP - 49

JO - Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

JF - Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

SN - 1070-8022

IS - 1

ER -

A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this