A cardioinhibitory area in the midbrain central tegmental field of cats

Anya M Y Lin, C. M. Pan, Yu-Fung Lin, J. S. Kuo, Samuel H H Chan, C. Y. Chai

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A cardioinhibitory area in the central tegmental field of the midbrain (CIM) was studied in cats under chloralose-urethane anesthesia. Electrical and chemical (glutamate and DL-homocysteic acid) stimulations in this area produced marked bradycardia accompanied by mostly hypotension or minimal change in arterial pressure and by occasional hypertension particularly in the dorsal portion. CIM excitation potentiated the reflex bradycardia induced by IV phenylephrine, while bilateral electrolytic lesion of CIM neither changed the resting cardiovascular parameters nor the reflex bradycardia. The CIM bradycardia was not affected by supracollicular decerebration, but substantially reduced by unilateral vagotomy and completely eliminated by bilateral vagotomy. Destruction of the ambiguus nucleus (NA) and solitary and dorsal motor nuclei (NTS/DMV) abolished the bradycardia. Midline bisection at the midbrain-pontine level only slightly reduced the bradycardia while at the medullary level it was moderately attenuated. Electrolytic lesion of the cardioinhibitory area in gigantocellular reticular nucleus (GRN) abolished the bradycardia. These findings suggest that CIM is an independent mechanism which may send axons to GRN from which the axons may in turn synapse with the NTS/DMV complex and NA. Its final output may utilize both vagus nerves to modulate baroreceptor reflex in promoting bradycardia.

Original languageEnglish (US)
Pages (from-to)699-707
Number of pages9
JournalBrain Research Bulletin
Volume18
Issue number6
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Bradycardia
Mesencephalon
Cats
Vagotomy
Axons
Reflex
Medulla Oblongata
Chloralose
Solitary Nucleus
Vagus Nerve
Baroreflex
Urethane
Phenylephrine
Hypotension
Synapses
Glutamic Acid
Arterial Pressure
Anesthesia
Hypertension

Keywords

  • Ambiguus nucleus
  • Cardioinhibition
  • Central tegmental field
  • Dorsal motor nucleus
  • Gigantocellular reticular nucleus
  • Midbrain
  • Reflex bradycardia
  • Solitary nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A cardioinhibitory area in the midbrain central tegmental field of cats. / Lin, Anya M Y; Pan, C. M.; Lin, Yu-Fung; Kuo, J. S.; Chan, Samuel H H; Chai, C. Y.

In: Brain Research Bulletin, Vol. 18, No. 6, 1987, p. 699-707.

Research output: Contribution to journalArticle

Lin, Anya M Y ; Pan, C. M. ; Lin, Yu-Fung ; Kuo, J. S. ; Chan, Samuel H H ; Chai, C. Y. / A cardioinhibitory area in the midbrain central tegmental field of cats. In: Brain Research Bulletin. 1987 ; Vol. 18, No. 6. pp. 699-707.
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