A burst of c-fos gene expression in the mouse occurs at birth.

J. W. Kasik, Yu-Jui Yvonne Wan, K. Ozato

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Expression of the c-fos gene during murine perinatal development was studied. Before birth, all eight of the prenatal organs tested expressed undetectable or low levels of c-fos mRNA. On the day of birth, there occurred a 10- to 100-fold increase in the level of c-fos message in all of these organs. The expression was transient, in that 1 day after birth, the level of c-fos mRNA precipitously dropped. The c-fos gene expression at birth is unrelated to the expression of the c-myc gene and major histocompatibility complex class I genes, which display distinct kinetics during the perinatal development. The c-fos gene was also expressed locally and transiently in the gravid uterus 1 to 2 days prior to delivery. These results indicate that an event associated with birth induced c-fos gene expression in the mother and newborn.

Original languageEnglish (US)
Pages (from-to)3349-3352
Number of pages4
JournalMolecular and Cellular Biology
Issue number9
StatePublished - Sep 1987
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Genetics
  • Molecular Biology


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