A burst of c-fos gene expression in the mouse occurs at birth.

J. W. Kasik, Yu-Jui Yvonne Wan, K. Ozato

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Expression of the c-fos gene during murine perinatal development was studied. Before birth, all eight of the prenatal organs tested expressed undetectable or low levels of c-fos mRNA. On the day of birth, there occurred a 10- to 100-fold increase in the level of c-fos message in all of these organs. The expression was transient, in that 1 day after birth, the level of c-fos mRNA precipitously dropped. The c-fos gene expression at birth is unrelated to the expression of the c-myc gene and major histocompatibility complex class I genes, which display distinct kinetics during the perinatal development. The c-fos gene was also expressed locally and transiently in the gravid uterus 1 to 2 days prior to delivery. These results indicate that an event associated with birth induced c-fos gene expression in the mother and newborn.

Original languageEnglish (US)
Pages (from-to)3349-3352
Number of pages4
JournalMolecular and Cellular Biology
Volume7
Issue number9
StatePublished - Sep 1987
Externally publishedYes

Fingerprint

fos Genes
Parturition
Gene Expression
MHC Class I Genes
Messenger RNA
myc Genes
Major Histocompatibility Complex
Uterus

ASJC Scopus subject areas

  • Cell Biology
  • Genetics
  • Molecular Biology

Cite this

A burst of c-fos gene expression in the mouse occurs at birth. / Kasik, J. W.; Wan, Yu-Jui Yvonne; Ozato, K.

In: Molecular and Cellular Biology, Vol. 7, No. 9, 09.1987, p. 3349-3352.

Research output: Contribution to journalArticle

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