A bursal pentapeptide (BPP-I), a novel bursal-derived peptide, exhibits antiproliferation of tumor cell and immunomodulator activity

Xiuli Feng, Qing T. Liu, Rui B. Cao, Bin Zhou, Fang Q. Wang, Wen L. Deng, Ya F. Qiu, Yu Zhang, Hassan Ishag, Zhi Y. Ma, Qi S. Zheng, Pu Y. Chen

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The bursa of Fabricius (BF) is the central humoral immune organ unique to birds. Here, we isolated a novel bursal pentapeptide I (BPP-I), LGPGP, from BF. BPP-I could play inhibition effect on MCF-7 but not on CEF or Vero cell proliferation in vitro, and enhance antitumor factor p53 protein expression. Also, BPP-I stimulated antibody production in a dose-dependent manner in hybridoma cell. Furthermore, BPP-I could induce various immune responses in mice immunization experiments, including increase antibody production and cytokines IL-4 and IFN-γ level, and induce T-cell immunophenotyping. These results suggest that BPP-I is a potential immunomodulator of antitumor and immunity. The study could provide some novel insights on the probable candidate reagent for the antitumor and immune improvement.

Original languageEnglish (US)
Pages (from-to)2215-2222
Number of pages8
JournalAmino Acids
Volume42
Issue number6
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

Keywords

  • Antiproliferation on tumor cell
  • Antitumor factor p53
  • Bursal pentapeptide
  • Hybridoma cell
  • Immunodominant functions

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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