A bipolar kinesin

A. S. Kashina, R. J. Baskin, D. G. Cole, K. P. Wedaman, W. M. Saxton, J. M. Scholey

Research output: Contribution to journalArticlepeer-review

292 Scopus citations


CHROMOSOME segregation during mitosis depends on the action of the mitotic spindle, a self organizing, bipolar protein machine which uses microtubules (MTs) and their associated motors. Members of the BimC subfamily of kinesin related MT-motor proteins are believed to be essential for the formation and functioning of a normal bipolar spindle. Here we report that KRP130, a homotetrameric BimC-related kinesin purified from Drosophila melanogaster embryos, has an unusual ultrastructure. It consists of four kinesin-related polypeptides assembled into a bipolar aggregate with motor domains at opposite ends, analogous to a miniature myosin filament. Such a bipolar 'minifilament' could crosslink spindle MTs and slide them relative to one another. We do not know of any other MT motors that have a bipolar structure.

Original languageEnglish (US)
Pages (from-to)270-272
Number of pages3
Issue number6562
StatePublished - Jan 18 1996

ASJC Scopus subject areas

  • General


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