A 6000 kb segment of chromosome 1 is conserved in human and mouse

S. F. Kingsmore, M. L. Watson, T. A. Howard, Michael F Seldin

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

A murine linkage map generated from analyses of 428 meiotic events in an interspecific cross and pulsed field gel electrophoresis allowed examination of the genomic organization of a 6000 kb segment of mouse and human chromosome 1. Analysis of five genes within this syntenic segment of both species revealed striking conservation of gene order, intergenic distance, and, to a lesser extent, CpG dinucleotides. In the mouse, meiotic crossover events were not evenly distributed; a hot spot for meiotic recombination was coincident with a CpG-island. These studies provide a practical approach to aid physical mapping of the human genome and a model for determining the molecular principles that govern meoitic recombination. In addition, these findings demonstrate profound conservation of genomic organization over mammalian evolution.

Original languageEnglish (US)
Pages (from-to)4073-4080
Number of pages8
JournalEMBO Journal
Volume8
Issue number13
StatePublished - 1989
Externally publishedYes

Keywords

  • 'CpG-islands'
  • chromosome 1
  • evolution
  • genomic organization
  • meiotic recombination

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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