A β2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav 1.2

M. A. Davare, V. Avdonin, D. D. Hall, E. M. Peden, A. Burette, R. J. Weinberg, Mary C Horne, T. Hoshi, Johannes W Hell

Research output: Contribution to journalArticle

419 Scopus citations

Abstract

The existence of a large number of receptors coupled to heterotrimeric guanine nucleotide binding proteins (G proteins) raises the question of how a particular receptor selectively regulates specific targets. We provide insight into this question by identifying a prototypical macromolecular signaling complex. The β2 adrenergic receptor was found to be directly associated with one of its ultimate effectors, the class C L-type calcium channel Cav 1.2. This complex also contained a G protein, an adenylyl cyclase, cyclic adenosine monophosphate-dependent protein kinase, and the counterbalancing phosphatase PP2A. Our electrophysiological recordings from hippocampal neurons demonstrate highly localized signal transduction from the receptor to the channel. The assembly of this signaling complex provides a mechanism that ensures specific and rapid signaling by a G protein-coupled receptor.

Original languageEnglish (US)
Pages (from-to)98-101
Number of pages4
JournalScience
Volume293
Issue number5527
DOIs
StatePublished - Jul 6 2001
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Davare, M. A., Avdonin, V., Hall, D. D., Peden, E. M., Burette, A., Weinberg, R. J., Horne, M. C., Hoshi, T., & Hell, J. W. (2001). A β2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav 1.2. Science, 293(5527), 98-101. https://doi.org/10.1126/science.293.5527.98