Find Research Outputs

Search in all content

Filters for Research Output

Search concepts
Selected Filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016

Author

  • Primo N Lara
2020

Down-regulation of ADRB2 expression is associated with small cell neuroendocrine prostate cancer and adverse clinical outcomes in castration-resistant prostate cancer

Kwon, D. H., Zhang, L., Quigley, D. A., Foye, A., Chen, W. S., Wong, C. K., Feng, F. Y., Bailey, A., Huang, J., Stuart, J. M., Friedl, V., Weinstein, A. S., Beer, T. M., Alumkal, J. J., Rettig, M., Gleave, M., Lara, P. N., Thomas, G. V., Li, P., Lui, A. & 2 others, Small, E. J. & Aggarwal, R. R., 2020, (Accepted/In press) In : Urologic Oncology: Seminars and Original Investigations.

Research output: Contribution to journalArticle

1 Scopus citations
2019

An open-label phase IB study to evaluate GSK3052230 in combination with paclitaxel and carboplatin, or docetaxel, in FGFR1-amplified non-small cell lung cancer

Morgensztern, D., Karaseva, N., Felip, E., Delgado, I., Burdaeva, O., Dómine, M., Lara, P. N., Paik, P. K., Lassen, U., Orlov, S., Trigo, J., Shomova, M., Baker-Neblett, K., Vasquez, J., Wang, X., Yan, L., Mitrica, I., DeYoung, M. P. & Garrido, P., Oct 1 2019, In : Lung Cancer. 136, p. 74-79 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

A Population-Based Study of Incidence and Survival of 1588 Thymic Malignancies: Results From the California Cancer Registry

Benjamin, D. J., Klapheke, A., Lara, P. N., Cress, R. D. & Riess, J., Jan 1 2019, (Accepted/In press) In : Clinical lung cancer.

Research output: Contribution to journalArticle

1 Scopus citations

Considerations for the Next Clinical Trial Evaluating the Role of Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma

Kim, H. L., Mayerson, E., Lara, P. N., Messing, E., Tangen, C., Shuch, B. M. & Vaishampayan, U., Jan 1 2019, In : European Urology Focus.

Research output: Contribution to journalComment/debate

4 Scopus citations

First-in-human study of mivebresib (ABBV-075), an oral pan-inhibitor of bromodomain and extra terminal proteins, in patients with relapsed/ refractory solid tumors

Piha-Paul, S. A., Sachdev, J. C., Barve, M., LoRusso, P., Szmulewitz, R., Patel, S. P., Lara, P. N., Chen, X., Hu, B., Freise, K. J., Modi, D., Sood, A., Hutti, J. E., Wolff, J. & O'Neil, B. H., Nov 1 2019, In : Clinical Cancer Research. 25, 21, p. 6309-6319 11 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Genomic Drivers of Poor Prognosis and Enzalutamide Resistance in Metastatic Castration-resistant Prostate Cancer

Chen, W. S., Aggarwal, R., Zhang, L., Zhao, S. G., Thomas, G. V., Beer, T. M., Quigley, D. A., Foye, A., Playdle, D., Huang, J., Lloyd, P., Lu, E., Sun, D., Guan, X., Rettig, M., Gleave, M., Evans, C. P., Youngren, J., True, L., Lara, P. N. & 8 others, Kothari, V., Xia, Z., Chi, K. N., Reiter, R. E., Maher, C. A., Feng, F. Y., Small, E. J. & Alumkal, J. J., Jan 1 2019, In : European Urology.

Research output: Contribution to journalArticle

15 Scopus citations

Immunohistochemical expression of renin is a prognostic factor for recurrence in nonmetastatic renal cell carcinoma

de Almeida e Paula, F., Bezerra, S. M., da Cunha, I. W., Munhoz, G. C., Abreu, D., Lara, P. N., da Costa, W. H. & Zéqui, S. D. C., Jan 1 2019, (Accepted/In press) In : Urologic Oncology: Seminars and Original Investigations.

Research output: Contribution to journalArticle

Influence of the facility caseload on the subsequent survival of men with localized prostate cancer undergoing radical prostatectomy

Barzi, A., Lara, P. N., Tsao-Wei, D., Yang, D., Gill, I. S., Daneshmand, S., Klein, E. A., Pinski, J. K., Penson, D. F., Quinn, D. I. & Sadeghi, S., Jan 1 2019, (Accepted/In press) In : Cancer.

Research output: Contribution to journalArticle

1 Scopus citations

Pan-cancer analysis of BRCA1 and BRCA2 genomic alterations and their association with genomic instability as measured by genome-wide loss of heterozygosity

Sokol, E. S., Pavlick, D., Khiabanian, H., Frampton, G. M., Ross, J. S., Gregg, J. P., Lara, P. N., Oesterreich, S., Agarwal, N., Necchi, A., Miller, V. A., Alexander, B., Ali, S. M., Ganesan, S. & Chung, J. H., Jan 1 2019, In : JCO Precision Oncology. 3, p. 442-465 24 p.

Research output: Contribution to journalArticle

Open Access

Phase II, Multicenter, Randomized Trial of Docetaxel plus Prednisone with or Without Cediranib in Men with Chemotherapy-Naive Metastatic Castrate-Resistant Prostate Cancer

Heath, E., Heilbrun, L., Mannuel, H., Liu, G., Lara, P. N., Monk, J. P., Flaig, T., Zurita, A., Mack, P., Vaishampayan, U., Stella, P., Smith, D., Bolton, S., Hussain, A., Al-Janadi, A., Silbiger, D., Usman, M. & Ivy, S. P., Jan 1 2019, In : Oncologist.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Phase II California Cancer consortium trial of gemcitabine-eribulin combination in cisplatin-ineligible patients with metastatic urothelial carcinoma: Final Report (NCI-9653)

Sadeghi, S., Groshen, S. G., Tsao-Wei, D. D., Parikh, R., Mortazavi, A., Dorff, T. B., Kefauver, C., Hoimes, C., Doyle, L., Quinn, D. I., Newman, E. & Lara, P. N., Oct 10 2019, In : Journal of Clinical Oncology. 37, 29, p. 2682-2688 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
7 Scopus citations

Prospective comprehensive genomic profiling of primary and metastatic prostate tumors

Chung, J. H., Dewal, N., Sokol, E., Mathew, P., Whitehead, R., Millis, S. Z., Frampton, G. M., Bratslavsky, G., Pal, S. K., Lee, R. J., Necchi, A., Gregg, J. P., Lara, P., Antonarakis, E. S., Miller, V. A., Ross, J. S., Ali, S. M. & Agarwal, N., Jan 1 2019, In : JCO Precision Oncology. 3

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype

Cai, D., Wang, J., Gao, B., Li, J., Wu, F., Zou, J. X., Xu, J., Jiang, Y., Zou, H., Huang, Z., Borowsky, A. D., Bold, R. J., Lara, P. N., Li, J. J., Chen, X., Lam, K. S., To, K. F., Kung, H. J., Fiehn, O., Zhao, R. & 2 others, Evans, R. M. & Chen, H. W., Dec 1 2019, In : Nature communications. 10, 1, 4621.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

SWOG S1400D (NCT02965378), a Phase II Study of the Fibroblast Growth Factor Receptor Inhibitor AZD4547 in Previously Treated Patients With Fibroblast Growth Factor Pathway–Activated Stage IV Squamous Cell Lung Cancer (Lung-MAP Substudy)

Aggarwal, C., Redman, M. W., Lara, P. N., Borghaei, H., Hoffman, P., Bradley, J. D., Newman, A. J., Feldman, M. J., Minichiello, K., Miao, J., Mack, P. C., Papadimitrakopoulou, V. A., Herbst, R. S., Kelly, K. & Gandara, D. R., Jan 1 2019, In : Journal of Thoracic Oncology.

Research output: Contribution to journalArticle

9 Scopus citations

The future of perioperative therapy in advanced renal cell carcinoma: How can we PROSPER?

Patel, H. D., Puligandla, M., Shuch, B. M., Leibovich, B. C., Kapoor, A., Master, V. A., Drake, C. G., Heng, D. Y. C., Lara, P. N., Choueiri, T. K., Maskens, D., Singer, E. A., Eggener, S. E., Svatek, R. S., Stadler, W. M., Cole, S., Signoretti, S., Gupta, R. T., Michaelson, M. D., McDermott, D. F. & 6 others, Cella, D., Wagner, L. I., Haas, N. B., Carducci, M. A., Harshman, L. C. & Allaf, M. E., May 1 2019, In : Future Oncology. 15, 15, p. 1683-1695 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Whole-Genome and Transcriptional Analysis of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer Demonstrates Intraclass Heterogeneity

Aggarwal, R. R., Quigley, D. A., Huang, J., Zhang, L., Beer, T. M., Rettig, M. B., Reiter, R. E., Gleave, M. E., Thomas, G. V., Foye, A., Playdle, D., Lloyd, P., Chi, K. N., Evans, C. P., Lara, P. N., Feng, F. Y., Alumkal, J. J. & Small, E. J., Jun 1 2019, In : Molecular cancer research : MCR. 17, 6, p. 1235-1240 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Bioengineered noncoding RNAs selectively change cellular miRNome profiles for cancer therapy

Ho, P. Y., Duan, Z., Batra, N., Jilek, J. L., Tu, M. J., Qiu, J. X., Hu, Z., Wun, T., Lara, P. N., deVere White, R. W., Chen, H. & Yu, A., Jun 1 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 494-506 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Bone turnover biomarkers identify unique prognostic risk groups in men with castration resistant prostate cancer and skeletal metastases: Results from SWOG S0421

Lara, P. N., Plets, M., Tangen, C., Gertz, E., Vogelzang, N. J., Hussain, M., Twardowski, P. W., Garzotto, M. G., Monk, J. P., Carducci, M., Goldkorn, A., Mack, P., Thompson, I., Van Loan, M. & Quinn, D. I., Jan 1 2018, In : Cancer Treatment and Research Communications. 16, p. 18-23 6 p.

Research output: Contribution to journalArticle

Clinical and genomic characterization of treatment-emergent small-cell neuroendocrine prostate cancer: A multi-institutional prospective study

Aggarwal, R., Huang, J., Alumkal, J. J., Zhang, L., Feng, F. Y., Thomas, G. V., Weinstein, A. S., Friedl, V., Zhang, C., Witte, O. N., Lloyd, P., Gleave, M., Evans, C. P., Youngren, J., Beer, T. M., Rettig, M., Wong, C. K., True, L., Foye, A., Playdle, D. & 11 others, Ryan, C. J., Lara, P. N., Chi, K. N., Uzunangelov, V., Sokolov, A., Newton, Y., Beltran, H., Demichelis, F., Rubin, M. A., Stuart, J. M. & Small, E. J., Aug 20 2018, In : Journal of Clinical Oncology. 36, 24, p. 2492-2503 12 p.

Research output: Contribution to journalArticle

107 Scopus citations

Cytoreductive Nephrectomy in Metastatic Renal Cell Cancer: Not All That It's Cut Out to Be

Lara, P. N. & Evans, C. P., Jan 1 2018, (Accepted/In press) In : JAMA oncology.

Research output: Contribution to journalArticle

1 Scopus citations

Diverse EGFR Exon 20 Insertions and Co-Occurring Molecular Alterations Identified by Comprehensive Genomic Profiling of NSCLC

Riess, J., Gandara, D. R., Frampton, G. M., Madison, R., Peled, N., Bufill, J. A., Dy, G. K., Ou, S. H. I., Stephens, P. J., Mcpherson, J. D., Lara, P. N., Burich, R. A., Ross, J. S., Miller, V. A., Ali, S. M., Mack, P. & Schrock, A. B., Oct 1 2018, In : Journal of Thoracic Oncology. 13, 10, p. 1560-1568 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Editorial Comment

Dall'Era, M. & Lara, P. N., Nov 1 2018, In : Journal of Urology. 200, 5, 1 p.

Research output: Contribution to journalComment/debate

Erratum: Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer (Cell (2018) 174(3) (758–769.e9), (S0092867418308420) (10.1016/j.cell.2018.06.039))

Quigley, D. A., Dang, H. X., Zhao, S. G., Lloyd, P., Aggarwal, R., Alumkal, J. J., Foye, A., Kothari, V., Perry, M. D., Bailey, A. M., Playdle, D., Barnard, T. J., Zhang, L., Zhang, J., Youngren, J. F., Cieslik, M. P., Parolia, A., Beer, T. M., Thomas, G., Chi, K. N. & 43 others, Gleave, M., Lack, N. A., Zoubeidi, A., Reiter, R. E., Rettig, M. B., Witte, O., Ryan, C. J., Fong, L., Kim, W., Friedlander, T., Chou, J., Li, H., Das, R., Li, H., Moussavi-Baygi, R., Goodarzi, H., Gilbert, L. A., Lara, P. N., Evans, C. P., Goldstein, T. C., Stuart, J. M., Tomlins, S. A., Spratt, D. E., Cheetham, R. K., Cheng, D. T., Farh, K., Gehring, J. S., Hakenberg, J., Liao, A., Febbo, P. G., Shon, J., Sickler, B., Batzoglou, S., Knudsen, K. E., He, H. H., Huang, J., Wyatt, A. W., Dehm, S. M., Ashworth, A., Chinnaiyan, A. M., Maher, C. A., Small, E. J. & Feng, F. Y., Oct 18 2018, In : Cell. 175, 3, 1 p.

Research output: Contribution to journalComment/debate

8 Scopus citations

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer

Quigley, D. A., Dang, H. X., Zhao, S. G., Lloyd, P., Aggarwal, R., Alumkal, J. J., Foye, A., Kothari, V., Perry, M. D., Bailey, A. M., Playdle, D., Barnard, T. J., Zhang, L., Zhang, J., Youngren, J. F., Cieslik, M. P., Parolia, A., Beer, T. M., Thomas, G., Chi, K. N. & 43 others, Gleave, M., Lack, N. A., Zoubeidi, A., Reiter, R. E., Rettig, M. B., Witte, O., Ryan, C. J., Fong, L., Kim, W., Friedlander, T., Chou, J., Li, H., Das, R., Li, H., Moussavi-Baygi, R., Goodarzi, H., Gilbert, L. A., Lara, P. N., Evans, C. P., Goldstein, T. C., Stuart, J. M., Tomlins, S. A., Spratt, D. E., Cheetham, R. K., Cheng, D. T., Farh, K., Gehring, J. S., Hakenberg, J., Liao, A., Febbo, P. G., Shon, J., Sickler, B., Batzoglou, S., Knudsen, K. E., He, H. H., Huang, J., Wyatt, A. W., Dehm, S. M., Ashworth, A., Chinnaiyan, A. M., Maher, C. A., Small, E. J. & Feng, F. Y., Jul 26 2018, In : Cell. 174, 3, p. 758-769.e9

Research output: Contribution to journalArticle

101 Scopus citations

In search of an oncogene driver for squamous lung cancer

Gandara, D. R., Riess, J. & Lara, P. N., Sep 1 2018, In : JAMA oncology. 4, 9, p. 1197-1198 2 p.

Research output: Contribution to journalComment/debate

Modern Systemic Therapy for Metastatic Renal Cell Carcinoma of the Clear Cell Type

Parikh, M. & Lara, P. N., Jan 29 2018, In : Annual Review of Medicine. 69, p. 209-221 13 p.

Research output: Contribution to journalReview article

3 Scopus citations

NCI 8628: a randomized phase 2 study of ziv-aflibercept and high-dose interleukin 2 or high-dose interleukin 2 alone for inoperable stage III or IV melanoma

Tarhini, A. A., Frankel, P., Ruel, C., Ernstoff, M. S., Kuzel, T. M., Logan, T. F., Khushalani, N. I., Tawbi, H. A., Margolin, K. A., Awasthi, S., Butterfield, L. H., McDermott, D., Chen, A., Lara, P. N. & Kirkwood, J. M., Jan 1 2018, (Accepted/In press) In : Cancer.

Research output: Contribution to journalArticle

2 Scopus citations

Patient-reported outcomes for patients with metastatic castration-resistant prostate cancer receiving docetaxel and atrasentan versus docetaxel and placebo in a randomized phase iii clinical trial (Swog s0421)

Unger, J. M., Griffin, K., Donaldson, G. W., Baranowski, K. M., Good, M. J., Reburiano, E., Hussain, M., Monk, P. J., Van Veldhuizen, P. J., Carducci, M. A., Higano, C. S., Lara, P. N., Tangen, C. M., Quinn, D. I., Wade, J. L., Vogelzang, N. J., Thompson, I. M. & Moinpour, C. M., Jan 1 2018, In : Journal of Patient-Reported Outcomes. 2, 27.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2 Scopus citations

Results of a Phase II Placebo-controlled Randomized Discontinuation Trial of Cabozantinib in Patients with Non–small-cell Lung Carcinoma

Hellerstedt, B. A., Vogelzang, N. J., Kluger, H. M., Yasenchak, C. A., Aftab, D. T., Ramies, D. A., Gordon, M. S. & Lara, P. N., Jan 1 2018, (Accepted/In press) In : Clinical Lung Cancer.

Research output: Contribution to journalArticle

5 Scopus citations
2017

A phase Ib/II study of cabozantinib (XL184) with or without erlotinib in patients with non-small cell lung cancer

Wakelee, H. A., Gettinger, S., Engelman, J., Jänne, P. A., West, H., Subramaniam, D. S., Leach, J., Wax, M., Yaron, Y., Miles, D. R. & Lara, P. N., Mar 28 2017, (Accepted/In press) In : Cancer Chemotherapy and Pharmacology. p. 1-10 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

A randomized phase 2 study of MK-2206 versus everolimus in refractory renal cell carcinoma

Jonasch, E., Hasanov, E., Corn, P. G., Moss, T., Shaw, K. R., Stovall, S., Marcott, V., Gan, B., Bird, S., Wang, X., Do, K. A., Altamirano, P. F., Zurita, A. J., Doyle, L. A., Lara, P. N. & Tannir, N. M., Apr 1 2017, In : Annals of Oncology. 28, 4, p. 804-808 5 p., mdw676.

Research output: Contribution to journalArticle

14 Scopus citations

Bevacizumab alone or in combination with TRC105 for patients with refractory metastatic renal cell cancer

Dorff, T. B., Longmate, J. A., Pal, S. K., Stadler, W. M., Fishman, M. N., Vaishampayan, U. N., Rao, A., Pinksi, J. K., Hu, J. S., Quinn, D. I. & Lara, P. N., Dec 1 2017, In : Cancer. 123, 23, p. 4566-4573 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Clinical predictors of survival in young patients with small cell lung cancer: Results from the California Cancer Registry

Lara, J. D., Brunson, A., Riess, J., Kelly, K., Lara, P. N. & Gandara, D. R., Oct 1 2017, In : Lung Cancer. 112, p. 165-168 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Co-targeting of DNA, RNA, and protein molecules provides optimal outcomes for treating osteosarcoma and pulmonary metastasis in spontaneous and experimental metastasis mouse models

Jian, C., Tu, M. J., Ho, P. Y., Duan, Z., Zhang, Q., Qiu, J. X., deVere White, R. W., Wun, T., Lara, P. N., Lam, K., Yu, A. X. & Yu, A., 2017, In : Oncotarget. 8, 19, p. 30742-30755 14 p.

Research output: Contribution to journalArticle

11 Scopus citations
2 Scopus citations

Metabolic reprogramming in clear cell renal cell carcinoma

Wettersten, H. I., Abuaboud, O., Lara, P. N. & Weiss, R. H., Jul 1 2017, In : Nature Reviews Nephrology. 13, 7, p. 410-419 10 p.

Research output: Contribution to journalReview article

59 Scopus citations

Phase II study of dovitinib in patients progressing on anti-vascular endothelial growth factor therapy

Semrad, T., Kim, E., Tanaka, M., Sands, J., Roberts, C., Burich, R. A., Li, Y., Gandara, D. R., Lara, P. N. & Mack, P., Jan 1 2017, In : Cancer Treatment and Research Communications. 10, p. 21-26 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

TMPRSS2-ERG fusions unexpectedly identified in men initially diagnosed with nonprostatic malignancies

Lara, P. N., Heilmann, A. M., Elvin, J. A., Parikh, M., White, R. D. V., Gandour-Edwards, R., Evans, C. P., Pan, C. X., Schrock, A. B., Erlich, R., Ross, J. S., Stephens, P. J., McPherson, J., Miller, V. A. & Ali, S. M., Jan 1 2017, In : JCO Precision Oncology. 2017, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Trametinib plus 4-Methylumbelliferone Exhibits Antitumor Effects by ERK Blockade and CD44 Downregulation and Affects PD-1 and PD-L1 in Malignant Pleural Mesothelioma

Cho, H., Matsumoto, S., Fujita, Y., Kuroda, A., Menju, T., Sonobe, M., Kondo, N., Torii, I., Nakano, T., Lara, P. N., Gandara, D. R., Date, H. & Hasegawa, S., Mar 1 2017, In : Journal of Thoracic Oncology. 12, 3, p. 477-490 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Validation of the Association of RECIST Changes With Survival in Men With Metastatic Castration-Resistant Prostate Cancer Treated on SWOG Study S0421

Sonpavde, G., Pond, G. R., Plets, M., Tangen, C. M., Hussain, M. H. A., Lara, P. N., Goldkorn, A., Garzotto, M. G., Mack, P., Higano, C. S., Vogelzang, N. J., Thompson, I. M., Twardowski, P. W., Van Veldhuizen, P. J., Agarwal, N., Carducci, M. A., Monk, J. P. & Quinn, D. I., Mar 18 2017, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

2 Scopus citations
2016
26 Scopus citations

A phase II study of vascular endothelial growth factor trap (Aflibercept, NSC 724770) in patients with myelodysplastic syndrome: A California Cancer Consortium Study

Kirschbaum, M. H., Frankel, P., Synold, T. W., Zain, J., Claxton, D., Tuscano, J., Newman, E. M., Gandara, D. R. & Lara, P. N., 2016, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticle

Evolving patterns of care in the management of stage I non-seminomatous germ cell tumors: data from the California Cancer Registry

Yap, S., Yuh, L. M., Evans, C. P., Dall'Era, M., Wagenaar, R. M., Cress, R. D. & Lara, P. N., Jun 15 2016, (Accepted/In press) In : World Journal of Urology. p. 1-7 7 p.

Research output: Contribution to journalArticle

2 Scopus citations