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  • Carlito B Lebrilla
2020

A nonenzymatic method for cleaving polysaccharides to yield oligosaccharides for structural analysis

Amicucci, M. J., Nandita, E., Galermo, A. G., Castillo, J. J., Chen, S., Park, D., Smilowitz, J. T., German, J. B., Mills, D. A. & Lebrilla, C. B., Dec 1 2020, In : Nature communications. 11, 1, 3963.

Research output: Contribution to journalArticle

Open Access

Comprehensive structural glycomic characterization of the glycocalyxes of cells and tissues

Li, Q., Xie, Y., Wong, M., Barboza Gardner, M. & Lebrilla, C. B., 2020, (Accepted/In press) In : Nature Protocols.

Research output: Contribution to journalArticle

Glycomic analysis of antibody indicates distinctive glycosylation profile in patients with autoimmune cholangitis

Zhou, X., Kailemia, M. J., Sun, Y., Shuai, Z., Yang, G. X., Dhaliwal, S., Cristoferi, L., Leung, P. S. C., Invernizzi, P., Bowlus, C., Lebrilla, C. B., Ansari, A. A., Ridgway, W. M., Zhang, W. & Gershwin, M. E., Jan 1 2020, (Accepted/In press) In : Journal of autoimmunity. 102503.

Research output: Contribution to journalArticle

Metastasis of cholangiocarcinoma is promoted by extended high-mannose glycans

Park, D. D., Phoomak, C., Xu, G., Olney, L. P., Tran, K. A., Park, S. S., Haigh, N. E., Luxardi, G., Lert-Itthiporn, W., Shimoda, M., Li, Q., Matoba, N., Fierro, F., Wongkham, S., Maverakis, E. & Lebrilla, C. B., Apr 7 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 14, p. 7633-7644 12 p.

Research output: Contribution to journalArticle

NIST interlaboratory study on glycosylation analysis of monoclonal antibodies: Comparison of results from diverse analytical methods

De Leoz, M. L. A., Duewer, D. L., Fung, A., Liu, L., Yau, H. K., Potter, O., Staples, G. O., Furuki, K., Frenkel, R., Hu, Y., Sosic, Z., Zhang, P., Altmann, F., Grunwald-Grube, C., Shao, C., Zaia, J., Evers, W., Pengelley, S., Suckau, D., Wiechmann, A. & 142 others, Resemann, A., Jabs, W., Beck, A., Froehlich, J. W., Huang, C., Li, Y., Liu, Y., Sun, S., Wang, Y., Seo, Y., An, H. J., Reichardt, N. C., Ruiz, J. E., Archer-Hartmann, S., Azadi, P., Bell, L., Lakos, Z., An, Y., Cipollo, J. F., Pucic-Bakovic, M., Štambuk, J., Lauc, G., Li, X., Wang, P. G., Bock, A., Hennig, R., Rapp, E., Creskey, M., Cyr, T. D., Nakano, M., Sugiyama, T., Leung, P. K. A., Link-Lenczowski, P., Jaworek, J., Yang, S., Zhang, H., Kelly, T., Klapoetke, S., Cao, R., Kim, J. Y., Lee, H. K., Lee, J. Y., Yoo, J. S., Kim, S. R., Suh, S. K., De Haan, N., Falck, D., Lageveen-Kammeijer, G. S. M., Wuhrer, M., Emery, R. J., Kozak, R. P., Liew, L. P., Royle, L., Urbanowicz, P. A., Packer, N. H., Song, X., Everest-Dass, A., Lattová, E., Cajic, S., Alagesan, K., Kolarich, D., Kasali, T., Lindo, V., Chen, Y., Goswami, K., Gau, B., Amunugama, R., Jones, R., Stroop, C. J. M., Kato, K., Yagi, H., Kondo, S., Yuen, C. T., Harazono, A., Shi, X., Magnelli, P. E., Kasper, B. T., Mahal, L., Harvey, D. J., O'Flaherty, R., Rudd, P. M., Saldova, R., Hecht, E. S., Muddiman, D. C., Kang, J., Bhoskar, P., Menard, D., Saati, A., Merle, C., Mast, S., Tep, S., Truong, J., Nishikaze, T., Sekiya, S., Shafer, A., Funaoka, S., Toyoda, M., De Vreugd, P., Caron, C., Pradhan, P., Tan, N. C., Mechref, Y., Patil, S., Rohrer, J. S., Chakrabarti, R., Dadke, D., Lahori, M., Zou, C., Cairo, C., Reiz, B., Whittal, R. M., Lebrilla, C. B., Wu, L., Guttman, A., Szigeti, M., Kremkow, B. G., Lee, K. H., Sihlbom, C., Adamczyk, B., Jin, C., Karlsson, N. G., Örnros, J., Larson, G., Nilsson, J., Meyer, B., Wiegandt, A., Komatsu, E., Perreault, H., Bodnar, E. D., Said, N., Francois, Y. N., Leize-Wagner, E., Maier, S., Zeck, A., Heck, A. J. R., Yang, Y., Haselberg, R., Yu, Y. Q., Alley, W., Leone, J. W., Yuan, H. & Stein, S. E., Jan 1 2020, In : Molecular and Cellular Proteomics. 19, 1, p. 11-30 20 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Sensory and monosaccharide analysis of drip brew coffee fractions versus brewing time

Batali, M. E., Frost, S. C., Lebrilla, C. B., Ristenpart, W. D. & Guinard, J. X., Jan 1 2020, (Accepted/In press) In : Journal of the Science of Food and Agriculture.

Research output: Contribution to journalArticle

1 Scopus citations

The DNA repair enzyme MUTYH potentiates cytotoxicity of the alkylating agent MNNG by interacting with abasic sites

Raetz, A. G., Banda, D. M., Ma, X., Xu, G., Rajavel, A. N., McKibbin, P. L., Lebrilla, C. B. & David, X. S. S., Mar 13 2020, In : Journal of Biological Chemistry. 295, 11, p. 3692-3707 16 p.

Research output: Contribution to journalArticle

Open Access

The proteomics of roadside hawk (Rupornis magnirostris), broad-snouted caiman (Caiman latirostris) and loggerhead sea turtle (Caretta caretta) tears

Raposo, A. C., Lebrilla, C. B., Portela, R. W., Goonatilleke, E., Neto, F. A. D. & Oriá, A. P., Aug 7 2020, In : BMC veterinary research. 16, 1, p. 276 1 p.

Research output: Contribution to journalArticle

Open Access
2019

A rapid-throughput adaptable method for determining the monosaccharide composition of polysaccharides

Amicucci, M. J., Galermo, A. G., Nandita, E., Vo, T. T. T., Liu, Y., Lee, M., Xu, G. & Lebrilla, C. B., Apr 1 2019, In : International Journal of Mass Spectrometry. 438, p. 22-28 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Characterization of Cell Glycocalyx with Mass Spectrometry Methods

Li, Q., Xie, Y., Wong, M. & Lebrilla, C. B., Aug 13 2019, In : Cells. 8, 8

Research output: Contribution to journalReview article

Open Access
3 Scopus citations

Development of an extensive linkage library for characterization of carbohydrates

Galermo, A. G., Nandita, E., Castillo, J. J., Amicucci, M. J. & Lebrilla, C. B., Jan 1 2019, (Accepted/In press) In : Analytical chemistry.

Research output: Contribution to journalArticle

3 Scopus citations

Discovery of serotransferrin glycoforms: Novel markers for diagnosis of liver periductal fibrosis and prediction of cholangiocarcinoma

Jamnongkan, W., Lebrilla, C. B., Barboza, M., Techasen, A., Loilome, W., Sithithaworn, P., Khuntikeo, N., Pairojkul, C., Chamadol, N., Thanan, R. & Yongvanit, P., Oct 2019, In : Biomolecules. 9, 10, 538.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Effects of N-glycosylation on the structure, function, and stability of a plant-made fc-fusion anthrax decoy protein

Xiong, Y., Karuppanan, K., Bernardi, A., Li, Q., Kommineni, V., Dandekar, A. M., Lebrilla, C. B., Faller, R., McDonald, K. A. & Nandi, S., May 31 2019, In : Frontiers in Plant Science. 10, 768.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Function without Structures: The Need for In-Depth Analysis of Dietary Carbohydrates

Amicucci, M. J., Nandita, E. & Lebrilla, C. B., Apr 24 2019, In : Journal of Agricultural and Food Chemistry. 67, 16, p. 4418-4424 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Human Milk Proteins and Their Glycosylation Exhibit Quantitative Dynamic Variations during Lactation

Goonatilleke, E., Huang, J., Xu, G., Wu, L., Smilowitz, J. T., German, J. B. & Lebrilla, C. B., Aug 1 2019, In : The Journal of nutrition. 149, 8, p. 1317-1325 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Identification of potential sialic acid binding proteins on cell membranes by proximity chemical labeling

Li, Q., Xie, Y., Xu, G. & Lebrilla, C. B., Jan 1 2019, In : Chemical Science. 10, 24, p. 6199-6209 11 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Immunoglobulin A N-glycosylation Presents Important Body Fluid-specific Variations in Lactating Mothers

Goonatilleke, E., Smilowitz, J. T., Mariño, K. V., German, B. J., Lebrilla, C. B. & Barboza, M., Nov 1 2019, In : Molecular & cellular proteomics : MCP. 18, 11, p. 2165-2177 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Infection-generated electric field in gut epithelium drives bidirectional migration of macrophages

Sun, Y., Reid, B., Ferreira, F., Luxardi, G., Ma, L., Lokken, K. L., Zhu, K., Xu, G., Sun, Y., Ryzhuk, V., Guo, B. P., Lebrilla, C. B., Maverakis, E., Mogilner, A. & Zhao, M., Apr 1 2019, In : PLoS biology. 17, 4, p. e3000044

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Nod-like receptors are critical for gut–brain axis signalling in mice

Pusceddu, M. M., Barboza, M., Keogh, C. E., Schneider, M., Stokes, P., Sladek, J. A., Kim, H. J. D., Torres-Fuentes, C., Goldfild, L. R., Gillis, S. E., Brust-Mascher, I., Rabasa, G., Wong, K. A., Lebrilla, C., Byndloss, M. X., Maisonneuve, C., Bäumler, A. J., Philpott, D. J., Ferrero, R. L., Barrett, K. E. & 2 others, Reardon, C. & Gareau, M. G., Dec 1 2019, In : Journal of Physiology. 597, 24, p. 5777-5797 21 p.

Research output: Contribution to journalArticle

5 Scopus citations

O-GlcNAc-induced nuclear translocation of hnRNP-K is associated with progression and metastasis of cholangiocarcinoma

Phoomak, C., Park, D., Silsirivanit, A., Sawanyawisuth, K., Vaeteewoottacharn, K., Detarya, M., Wongkham, C., Lebrilla, C. B. & Wongkham, S., Jan 1 2019, (Accepted/In press) In : Molecular Oncology.

Research output: Contribution to journalArticle

5 Scopus citations

Omics Forecasting: Predictive Calculations Permit the Rapid Interpretation of High-Resolution Mass Spectral Data from Complex Mixtures

Cave, J. R., Parker, E., Lebrilla, C. & Waterhouse, A. L., Jan 1 2019, (Accepted/In press) In : Journal of Agricultural and Food Chemistry.

Research output: Contribution to journalArticle

Purification and site-specific N-glycosylation analysis of human recombinant butyrylcholinesterase from Nicotiana benthamiana

Alkanaimsh, S., Corbin, J. M., Kailemia, M. J., Karuppanan, K., Rodriguez, R. L., Lebrilla, C. B., McDonald, K. A. & Nandi, S., Feb 15 2019, In : Biochemical Engineering Journal. 142, p. 58-67 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection

Bensing, B. A., Li, L., Yakovenko, O., Wong, M., Barnard, K. N., Iverson, T. M., Lebrilla, C. B., Parrish, C. R., Thomas, W. E., Xiong, Y. & Sullam, P. M., Jun 1 2019, In : PLoS pathogens. 15, 6, e1007896.

Research output: Contribution to journalArticle

Open Access

Selective Proteolysis of α-Lactalbumin by Endogenous Enzymes of Human Milk at Acidic pH

Gan, J., Zheng, J., Krishnakumar, N., Goonatilleke, E., Lebrilla, C. B., Barile, D. & German, J. B., Jan 1 2019, In : Molecular Nutrition and Food Research. 1900259.

Research output: Contribution to journalArticle

1 Scopus citations

Site-Specific Glycoprofiles of HDL-Associated ApoE are Correlated with HDL Functional Capacity and Unaffected by Short-Term Diet

Zhu, C., Wong, M., Li, Q., Sawrey-Kubicek, L., Beals, E., Rhodes, C. H., Sacchi, R., Lebrilla, C. B. & Zivkovic, A. M., Jan 1 2019, (Accepted/In press) In : Journal of Proteome Research.

Research output: Contribution to journalArticle

2 Scopus citations

Site-Specific Glycosylation Quantitation of 50 Serum Glycoproteins Enhanced by Predictive Glycopeptidomics for Improved Disease Biomarker Discovery

Li, Q., Kailemia, M. J., Merleev, A. A., Xu, G., Serie, D., Danan, L. M., Haj, F., Maverakis, E. M. & Lebrilla, C. B., Apr 16 2019, In : Analytical Chemistry. 91, 8, p. 5433-5445 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Strategy for Structural Elucidation of Polysaccharides: Elucidation of a Maize Mucilage that Harbors Diazotrophic Bacteria

Amicucci, M. J., Galermo, A. G., Guerrero, A., Treves, G., Nandita, E., Kailemia, M. J., Higdon, S. M., Pozzo, T., Labavitch, J. M., Bennett, A. B. & Lebrilla, C. B., Jan 1 2019, In : Analytical Chemistry.

Research output: Contribution to journalArticle

7 Scopus citations

T-cell derived acetylcholine aids host defenses during enteric bacterial infection with Citrobacter rodentium

Ramirez, V. T., Godinez, D. R., Brust-Mascher, I., Nonnecke, E. B., Castillo, P. A., Gardner, M. B., Tu, D., Sladek, J. A., Miller, E. N., Lebrilla, C. B., Bevins, C. L., Gareau, M. G. & Reardon, C., Apr 1 2019, In : PLoS pathogens. 15, 4, p. e1007719

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Unveiling the metabolic fate of monosaccharides in cell membranes with glycomic and glycoproteomic analyses

Xu, G., Wong, M., Li, Q., Park, D., Cheng, Z. & Lebrilla, C. B., Jan 1 2019, In : Chemical Science. 10, 29, p. 6992-7002 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

Biallelic Mutations in FUT8 Cause a Congenital Disorder of Glycosylation with Defective Fucosylation

Ng, B. G., Xu, G., Chandy, N., Steyermark, J., Shinde, D. N., Radtke, K., Raymond, K., Lebrilla, C. B., AlAsmari, A., Suchy, S. F., Powis, Z., Faqeih, E. A., Berry, S. A., Kronn, D. F. & Freeze, H. H., Jan 4 2018, In : American Journal of Human Genetics. 102, 1, p. 188-195 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

FGF2 Induces Migration of Human Bone Marrow Stromal Cells by Increasing Core Fucosylations on N-Glycans of Integrins

Awan, B., Turkov, D., Schumacher, C., Jacobo, A., McEnerney, A., Ramsey, A., Xu, G., Park, D., Kalomoiris, S., Yao, W., Jao, L-E., Allende, M. L., Lebrilla, C. B. & Fierro, F. A., Jan 1 2018, (Accepted/In press) In : Stem Cell Reports.

Research output: Contribution to journalArticle

12 Scopus citations

Genetic Ablation of Butyrate Utilization Attenuates Gastrointestinal Salmonella Disease

Bronner, D. N., Faber, F., Olsan, E. E., Byndloss, M. X., Sayed, N. A., Xu, G., Yoo, W., Kim, D., Ryu, S., Lebrilla, C. B. & Baumler, A. J., Feb 14 2018, In : Cell Host and Microbe. 23, 2, p. 266-273.e4

Research output: Contribution to journalArticle

13 Scopus citations

Glycoform modification of secreted recombinant glycoproteins through kifunensine addition during transient vacuum agroinfiltration

Xiong, Y., Li, Q., Kailemia, M. J., Lebrilla, C. B., Nandi, S. & McDonald, K. A., Mar 17 2018, In : International Journal of Molecular Sciences. 19, 3, 890.

Research output: Contribution to journalArticle

2 Scopus citations
3 Scopus citations

Liquid Chromatography-Tandem Mass Spectrometry Approach for Determining Glycosidic Linkages

Galermo, A. G., Nandita, E., Barboza Gardner, M., Amicucci, M. J., Vo, T. T. T. & Lebrilla, C. B., Jan 1 2018, (Accepted/In press) In : Analytical Chemistry.

Research output: Contribution to journalArticle

7 Scopus citations

Mass Spectrometry Approaches to Glycomic and Glycoproteomic Analyses

Ruhaak, L. R., Xu, G., Li, Q., Goonatilleke, E. & Lebrilla, C. B., Sep 12 2018, In : Chemical Reviews. 118, 17, p. 7886-7930 45 p.

Research output: Contribution to journalArticle

64 Scopus citations

Membrane glycomics reveal heterogeneity and quantitative distribution of cell surface sialylation

Park, D. D., Xu, G., Wong, M., Phoomak, C., Liu, M., Haigh, N. E., Wongkham, S., Yang, P., Maverakis, E. M. & Lebrilla, C. B., Jan 1 2018, In : Chemical Science. 9, 29, p. 6271-6285 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

Multiple Reaction Monitoring for the Quantitation of Serum Protein Glycosylation Profiles: Application to Ovarian Cancer

Miyamoto, S., Stroble, C. D., Taylor, S., Hong, Q., Lebrilla, C. B., Leiserowitz, G. S., Kim, K. & Ruhaak, L. R., Jan 5 2018, In : Journal of Proteome Research. 17, 1, p. 222-233 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

O-GlcNAcylation mediates metastasis of cholangiocarcinoma through FOXO3 and MAN1A1

Phoomak, C., Silsirivanit, A., Park, D., Sawanyawisuth, K., Vaeteewoottacharn, K., Wongkham, C., Lam, E. W. F., Pairojkul, C., Lebrilla, C. B. & Wongkham, S., Oct 18 2018, In : Oncogene. 37, 42, p. 5648-5665 18 p.

Research output: Contribution to journalArticle

9 Scopus citations

Purification, characterization, and N-glycosylation of recombinant butyrylcholinesterase from transgenic rice cell suspension cultures

Corbin, J. M., Kailemia, M. J., Cadieux, C. L., Alkanaimsh, S., Karuppanan, K., Rodriguez, R. L., Lebrilla, C. B., Cerasoli, D. M., McDonald, K. A. & Nandi, S., May 1 2018, In : Biotechnology and Bioengineering. 115, 5, p. 1301-1310 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Recent Advances in the Mass Spectrometry Methods for Glycomics and Cancer

Kailemia, M. J., Xu, G., Wong, M., Li, Q., Goonatilleke, E., Leon, F. & Lebrilla, C. B., Jan 2 2018, In : Analytical Chemistry. 90, 1, p. 208-224 17 p.

Research output: Contribution to journalReview article

24 Scopus citations

Revisiting monosaccharide analysis-quantitation of a comprehensive set of monosaccharides using dynamic multiple reaction monitoring

Xu, G., Amicucci, M. J., Cheng, Z., Galermo, A. G. & Lebrilla, C. B., Jan 7 2018, In : Analyst. 143, 1, p. 200-207 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Serum glycosylation characterization of osteonecrosis of the femoral head by mass spectrometry

Song, T., Chen, P., Stroble, C., Ruhaak, L. R., Wang, H., Li, Z., He, W. & Lebrilla, C. B., Feb 1 2018, In : European Journal of Mass Spectrometry. 24, 1, p. 178-187 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Streptococcal Siglec-like adhesins recognize different subsets of human plasma glycoproteins: Implications for infective endocarditis

Bensing, B. A., Li, Q., Park, D., Lebrilla, C. B. & Sullam, P. M., Aug 1 2018, In : Glycobiology. 28, 8, p. 601-611 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Targeted Measurements of O- and N-Glycopeptides Show That Proteins in High Density Lipoprotein Particles Are Enriched with Specific Glycosylation Compared to Plasma

Kailemia, M. J., Wei, W., Nguyen, K., Beals, E., Sawrey-Kubicek, L., Rhodes, C., Zhu, C., Sacchi, R., Zivkovic, A. M. & Lebrilla, C. B., Feb 2 2018, In : Journal of Proteome Research. 17, 2, p. 834-845 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Transient recombinant protein production in glycoengineered Nicotiana benthamiana cell suspension culture

Sukenik, S. C., Karuppanan, K., Li, Q., Lebrilla, C. B., Nandi, S. & McDonald, K. A., Apr 16 2018, In : International Journal of Molecular Sciences. 19, 4, 1205.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Absolute quantitation of human milk oligosaccharides reveals phenotypic variations during lactation

Xu, G., Davis, J. C. C., Goonatilleke, E., Smilowitz, J. T., German, J. B. & Lebrilla, C. B., 2017, In : Journal of Nutrition. 147, 1, p. 117-124 8 p.

Research output: Contribution to journalArticle

54 Scopus citations

Analysis of milk oligosaccharides by mass spectrometry

Wu, L. D., Ruhaak, L. R. & Lebrilla, C. B., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1503. p. 121-129 9 p. (Methods in Molecular Biology; vol. 1503).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Composition and Variation of Macronutrients, Immune Proteins, and Human Milk Oligosaccharides in Human Milk From Nonprofit and Commercial Milk Banks

Meredith-Dennis, L., Xu, G., Goonatilleke, E., Lebrilla, C. B., Underwood, M. & Smilowitz, J. T., Jun 1 2017, (Accepted/In press) In : Journal of Human Lactation.

Research output: Contribution to journalArticle

22 Scopus citations