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  • Kit Lam
2020
Open Access

Discovery and mechanistic characterization of a structurally-unique membrane active peptide

Bansal, S., Su, W. C., Budamagunta, M., Xiao, W., Ajena, Y., Liu, R., Voss, J. C., Carney, R., Parikh, A. N. & Lam, K. S., Oct 1 2020, In : Biochimica et Biophysica Acta - Biomembranes. 1862, 10, 183394.

Research output: Contribution to journalArticle

Open Access

Rapid endothelialization of small diameter vascular grafts by a bioactive integrin-binding ligand specifically targeting endothelial progenitor cells and endothelial cells

Hao, D., Fan, Y., Xiao, W., Liu, R., Pivetti, C., Walimbe, T., Guo, F., Zhang, X., Farmer, D. L., Wang, F., Panitch, A., Lam, K. S. & Wang, A., Jan 1 2020, (Accepted/In press) In : Acta Biomaterialia.

Research output: Contribution to journalArticle

3 Scopus citations

Sequential Targeting in Crosslinking Nanotheranostics for Tackling the Multibarriers of Brain Tumors

Wu, H., Lu, H., Xiao, W., Yang, J., Du, H., Shen, Y., Qu, H., Jia, B., Manna, S. K., Ramachandran, M., Xue, X., Ma, Z., Xu, X., Wang, Z., He, Y., Lam, K. S., Zawadzki, R. J., Li, Y. & Lin, T. Y., Jan 1 2020, (Accepted/In press) In : Advanced Materials. 1903759.

Research output: Contribution to journalArticle

1 Scopus citations

Size-Transformable Hyaluronan Stacked Self-Assembling Peptide Nanoparticles for Improved Transcellular Tumor Penetration and Photo-Chemo Combination Therapy

Cong, Z., Zhang, L., Ma, S. Q., Lam, K. S., Yang, F. F. & Liao, Y. H., Feb 25 2020, In : ACS Nano. 14, 2, p. 1958-1970 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Structure–activity relationship of RGD-containing cyclic octapeptide and αvβ3 integrin allows for rapid identification of a new peptide antagonist

Silva, A., Xiao, W., Wang, Y., Wang, W., Chang, H. W., Ames, J. B., Lam, K. S. & Zhang, Y., May 1 2020, In : International journal of molecular sciences. 21, 9, 3076.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Transformable peptide nanoparticles arrest HER2 signalling and cause cancer cell death in vivo

Zhang, L., Jing, D., Jiang, N., Rojalin, T., Baehr, C. M., Zhang, D., Xiao, W., Wu, Y., Cong, Z., Li, J. J., Li, Y., Wang, L. & Lam, K. S., Feb 1 2020, In : Nature Nanotechnology. 15, 2, p. 145-153 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Two-way magnetic resonance tuning and enhanced subtraction imaging for non-invasive and quantitative biological imaging

Wang, Z., Xue, X., Lu, H., He, Y., Lu, Z., Chen, Z., Yuan, Y., Tang, N., Dreyer, C. A., Quigley, L., Curro, N., Lam, K. S., Walton, J. H., Lin, T. Y., Louie, A. Y., Gilbert, D. A., Liu, K., Ferrara, K. W. & Li, Y., Jan 1 2020, (Accepted/In press) In : Nature Nanotechnology.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Affinity selection and sequencing

Lam, K., Apr 1 2019, In : Nature Chemical Biology. 15, 4, p. 320-321 2 p.

Research output: Contribution to journalArticle

6 Scopus citations

Alternative splicing of MXD3 and its regulation of MXD3 levels in glioblastoma

Ngo, T., Corrales, A., Bourne, T., Elmojahid, S., Lam, K. & Diaz, E. D., Jan 1 2019, In : Frontiers in Molecular Biosciences. 6, FEB, 00005.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Combinatorial Peptide Microarray Synthesis Based on Microfluidic Impact Printing

Li, J., Zhao, S., Yang, G., Liu, R., Xiao, W., Disano, P., Lam, K. & Pan, T., Jan 14 2019, In : ACS Combinatorial Science. 21, 1, p. 6-10 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
Open Access

Daunorubicin-containing CLL1-targeting nanomicelles have anti-leukemia stem cell activity in acute myeloid leukemia

Lin, T-Y., Zhu, Y., Li, Y., Zhang, H., Ma, A. H., Long, Q., Keck, J., Lam, K., Pan, C-X. & Jonas, B., Aug 1 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 20, 102004.

Research output: Contribution to journalArticle

5 Scopus citations

Dual blockage of STAT3 and ERK1/2 eliminates radioresistant GBM cells

Xie, B., Zhang, L., Hu, W., Fan, M., Jiang, N., Duan, Y., Jing, D., Xiao, W., Fragoso, R. C., Lam, K., Sun, L. Q. & Li, J-J., Jun 1 2019, In : Redox Biology. 24, 101189.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Galectin-1 inhibition induces cell apoptosis through dual suppression of CXCR4 and Ras pathways in human malignant peripheral nerve sheath tumors

Shih, T. C., Fan, Y., Kiss, S., Li, X., Deng, X. N., Liu, R., Chen, X. J., Carney, R., Chen, A., Ghosh, P. M. & Lam, K. S., Nov 4 2019, In : Neuro-Oncology. 21, 11, p. 1389-1400 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer

Xiao, W., Ma, W., Wei, S., Li, Q., Liu, R., Carney, R., Xiang, Y. K., Lee, J. S., Nyugen, A., Yoneda, K. Y., Lam, K. & Li, T., Jun 10 2019, In : Journal of Hematology and Oncology. 12, 1, 56.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Neuroprotective effect of placenta-derived mesenchymal stromal cells: role of exosomes

Kumar, P., Becker, J. C., Gao, K., Carney, R., Lankford, L., Keller, B. A., Herout, K., Lam, K., Farmer, D. L. & Wang, A., May 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 5, p. 5836-5849 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Novel window for cancer nanotheranostics: Non-invasive ocular assessments of tumor growth and nanotherapeutic treatment efficacy in vivo

Goswami, M., Wang, X., Zhang, P., Xiao, W., Karlen, S. J., Li, Y., Zawadzki, R., Burns, M. E., Lam, K. & Pugh Jr, E. N., Jan 1 2019, In : Biomedical Optics Express. 10, 1, p. 151-166 16 p.

Research output: Contribution to journalArticle

3 Scopus citations

Olig2 regulates terminal differentiation and maturation of peripheral olfactory sensory neurons

Wang, Y. Z., Fan, H., Ji, Y., Reynolds, K., Gu, R., Gan, Q., Yamagami, T., Zhao, T., Hamad, S., Bizen, N., Takebayashi, H., Chen, Y. P., Wu, S., Pleasure, D., Lam, K. & Zhou, C. J., Jan 1 2019, (Accepted/In press) In : Cellular and Molecular Life Sciences.

Research output: Contribution to journalArticle

One-bead one-compound combinatorial library derived targeting ligands for detection and treatment of oral squamous cancer

Yang, F., Xiao, W., Liu, Y., Liu, R., Kramer, R., Li, X., Ajena, Y., Baehr, C. M., Rojalin, T., Zhang, H. & Lam, K. S., Jan 1 2019, In : Oncotarget. 10, 52, p. 5468-5479 12 p.

Research output: Contribution to journalArticle

Peptide-based materials for cancer immunotherapy

Zhang, L., Huang, Y., Lindstrom, A. R., Lin, T. Y., Lam, K. S. & Li, Y., Jan 1 2019, In : Theranostics. 9, 25, p. 7807-7825 19 p.

Research output: Contribution to journalReview article

Open Access
6 Scopus citations

Rapid discovery of illuminating peptides for instant detection of opioids in blood and body fluids

Jafari, S., Thillier, Y., Ajena, Y. H., Shorty, D., Li, J., Huynh, J. S., Pan, B. M. C., Pan, T., Lam, K. & Liu, R., Jan 1 2019, In : Molecules. 24, 9, 1813.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype

Cai, D., Wang, J., Gao, B., Li, J., Wu, F., Zou, J. X., Xu, J., Jiang, Y., Zou, H., Huang, Z., Borowsky, A. D., Bold, R. J., Lara, P. N., Li, J. J., Chen, X., Lam, K. S., To, K. F., Kung, H. J., Fiehn, O., Zhao, R. & 2 others, Evans, R. M. & Chen, H. W., Dec 1 2019, In : Nature communications. 10, 1, 4621.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Tunable hydrogels for mesenchymal stem cell delivery: Integrin-induced transcriptome alterations and hydrogel optimization for human wound healing

Marusina, A. I., Merleev, A. A., Luna, J. I., Olney, L., Haigh, N. E., Yoon, D., Guo, C., Ovadia, E. M., Shimoda, M., Luxardi, G., Boddu, S., Lal, N. N., Takada, Y., Lam, K. S., Liu, R., Isseroff, R. R., Le, S., Nolta, J. A., Kloxin, A. M. & Maverakis, E., Jan 1 2019, (Accepted/In press) In : Stem Cells.

Research output: Contribution to journalArticle

2 Scopus citations
2018

A Plug-and-Play, Drug-on-Pillar Platform for Combination Drug Screening Implemented by Microfluidic Adaptive Printing

Li, J., Tan, W., Xiao, W., Carney, R., Men, Y., Li, Y., Quon, G., Ajena, Y., Lam, K. & Pan, T., Jan 1 2018, (Accepted/In press) In : Analytical Chemistry.

Research output: Contribution to journalArticle

5 Scopus citations

Corrigendum to ‘Tumor-targeting peptides from combinatorial libraries’ [Adv Drug Deliv Rev.110–111 (2017) 13–37]

Liu, R., Li, X., Xiao, W. & Lam, K., Jan 1 2018, (Accepted/In press) In : Advanced Drug Delivery Reviews.

Research output: Contribution to journalArticle

Identification of integrin drug targets for 17 solid tumor types

Arun, A. S., Tepper, C. G. & Lam, K., Jul 10 2018, In : Oncotarget. 9, 53, p. 30146-30162 17 p.

Research output: Contribution to journalArticle

6 Scopus citations

Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model

Long, Q., Lin, T-Y., Huang, Y., Li, X., Ma, A. H., Zhang, H., Carney, R., Airhart, S., Lam, K., deVere White, R. W., Pan, C-X. & Li, Y., Apr 1 2018, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 3, p. 789-799 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Microfluidic Print-to-Synthesis Platform for Efficient Preparation and Screening of Combinatorial Peptide Microarrays

Li, J., Carney, R., Liu, R., Fan, J., Zhao, S., Chen, Y., Lam, K. & Pan, T., May 1 2018, In : Analytical Chemistry. 90, 9, p. 5833-5840 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Nanoformulated paclitaxel and AZD9291 synergistically eradicate non-small-cell lung cancers in vivo

Wang, X. S., Zhang, L., Li, X., Kong, D. J., Hu, X. C., DIng, X. Z., Yang, J. Q., Zhao, M. Q., He, Y., Lam, K., Gao, S. G., Lin, T-Y. & Li, Y., May 1 2018, In : Nanomedicine. 13, 10, p. 1107-1120 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Novel Redox-Responsive Polymeric Magnetosomes with Tunable Magnetic Resonance Property for In Vivo Drug Release Visualization and Dual-Modal Cancer Therapy

Wang, Z., Xue, X., He, Y., Lu, Z., Jia, B., Wu, H., Yuan, Y., Huang, Y., Wang, H., Lu, H., Lam, K., Lin, T-Y. & Li, Y., Aug 15 2018, In : Advanced Functional Materials. 28, 33, 1802159.

Research output: Contribution to journalArticle

9 Scopus citations

Reply to Letter to the Editor

Lam, K., Feb 1 2018, In : Current Opinion in Chemical Biology. 42, 1 p.

Research output: Contribution to journalLetter

Reversibly disulfide cross-linked micelles improve the pharmacokinetics and facilitate the targeted, on-demand delivery of doxorubicin in the treatment of B-cell lymphoma

Xiao, K., Liu, Q., Al Awwad, N., Zhang, H., Lai, L., Luo, Y., Lee, J. S., Li, Y. & Lam, K., May 7 2018, In : Nanoscale. 10, 17, p. 8207-8216 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Size-Modulable Nanoprobe for High-Performance Ultrasound Imaging and Drug Delivery against Cancer

Zhang, L., Yin, T., Li, B., Zheng, R., Qiu, C., Lam, K., Zhang, Q. & Shuai, X., Apr 24 2018, In : ACS Nano. 12, 4, p. 3449-3460 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Targeting galectin-1 impairs castration-resistant prostate cancer progression and invasion

Shih, T. C., Liu, R., Wu, C. T., Li, X., Xiao, W., Deng, X., Kiss, S., Wang, T., Chen, X. J., Carney, R., Kung, H-J., Duan, Y., Ghosh, P. M. & Lam, K., Sep 1 2018, In : Clinical Cancer Research. 24, 17, p. 4319-4331 13 p.

Research output: Contribution to journalArticle

8 Scopus citations
2 Scopus citations

Unique Photochemo-Immuno-Nanoplatform against Orthotopic Xenograft Oral Cancer and Metastatic Syngeneic Breast Cancer

Zhang, L., Jing, D., Wang, L., Sun, Y., Li, J-J., Hill, B., Yang, F., Li, Y. & Lam, K., Nov 14 2018, In : Nano Letters. 18, 11, p. 7092-7103 12 p.

Research output: Contribution to journalArticle

20 Scopus citations
2017
5 Scopus citations

A novel galectin-1 inhibitor discovered through one-bead two-compound library potentiates the antitumor effects of paclitaxel in vivo

Shih, T. C., Liu, R., Fung, G., Bhardwaj, G., Ghosh, P. M. & Lam, K., Jul 1 2017, In : Molecular Cancer Therapeutics. 16, 7, p. 1212-1223 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

A versatile nanoplatform for synergistic combination therapy to treat human esophageal cancer

Wang, X. S., Kong, D. J., Lin, T-Y., Li, X. C., Izumiya, Y., Ding, X. Z., Zhang, L., Hu, X. C., Yang, J. Q., Gao, S. G., Lam, K. & Li, Y., Jun 1 2017, In : Acta Pharmacologica Sinica. 38, 6, p. 931-942 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Cell-free production of a functional oligomeric form of a Chlamydia major outer-membrane protein (MOMP) for vaccine development

He, W., Felderman, M., Evans, A. C., Geng, J., Homan, D., Bourguet, F., Fischer, N. O., Li, Y., Lam, K., Noy, A., Xing, L., Cheng, R. H., Rasley, A., Blanchette, C. D., Kamrud, K., Wang, N., Gouvis, H., Peterson, T. C., Hubby, B. & Coleman, M. A., 2017, In : Journal of Biological Chemistry. 292, 36, p. 15121-15132 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cholic acid-based novel micellar nanoplatform for delivering FDA-approved taxanes

Bharadwaj, G., Nhan, V., Yang, S. C., Li, X., Narayanan, A., MacArenco, A. C., Shi, Y., Yang, D., Vieira, L. S., Xiao, W., Li, Y. & Lam, K., May 1 2017, In : Nanomedicine. 12, 10, p. 1153-1164 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Combinatorial chemistry in drug discovery

Liu, R., Li, X. & Lam, K., Jun 1 2017, In : Current Opinion in Chemical Biology. 38, p. 117-126 10 p.

Research output: Contribution to journalReview article

67 Scopus citations

Combinatorial Library Screening with Liposomes for Discovery of Membrane Active Peptides

Carney, R., Thillier, Y., Kiss, Z., Sahabi, A., Heleno Campos, J. C., Knudson, A., Liu, R., Olivos, D., Saunders, M., Tian, L. & Lam, K., May 8 2017, In : ACS Combinatorial Science. 19, 5, p. 299-307 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Corrigendum: The 4D nucleome project (Nature (2017) 549 (219-226) DOI: 10.1038/nature23884)

4D Nucleome Network, Dec 14 2017, In : Nature. 552, 7684, 1 p.

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations

Co-targeting of DNA, RNA, and protein molecules provides optimal outcomes for treating osteosarcoma and pulmonary metastasis in spontaneous and experimental metastasis mouse models

Jian, C., Tu, M. J., Ho, P. Y., Duan, Z., Zhang, Q., Qiu, J. X., deVere White, R. W., Wun, T., Lara, P. N., Lam, K., Yu, A. X. & Yu, A., 2017, In : Oncotarget. 8, 19, p. 30742-30755 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration

Hao, D., Xiao, W., Liu, R., Kumar, P., Li, Y., Zhou, P., Guo, F., Farmer, D. L., Lam, K., Wang, F. & Wang, A., Apr 21 2017, In : ACS Chemical Biology. 12, 4, p. 1075-1086 12 p.

Research output: Contribution to journalArticle

20 Scopus citations