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  • William J Murphy
2020

Blood and tissue biomarker analysis in dogs with osteosarcoma treated with palliative radiation and intra-tumoral autologous natural killer cell transfer

Judge, S. J., Yanagisawa, M., Sturgill, I. R., Bateni, S. B., Gingrich, A. A., Foltz, J. A., Lee, D. A., Modiano, J. F., Monjazeb, A. M., Culp, W. T. N., Rebhun, R. B., Murphy, W. J., Kent, M. S. & Canter, R. J., Jan 1 2020, In : PloS one. 15, 2, e0224775.

Research output: Contribution to journalArticle

Open Access

Characterizing the Dysfunctional NK Cell: Assessing the Clinical Relevance of Exhaustion, Anergy, and Senescence

Judge, S. J., Murphy, W. J. & Canter, R. J., Jan 1 2020, In : Frontiers in Cellular and Infection Microbiology. 10, 1 p.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations

Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD

Blazar, B. R., Hill, G. R. & Murphy, W. J., Jan 1 2020, (Accepted/In press) In : Nature Reviews Clinical Oncology.

Research output: Contribution to journalReview article

Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease

Thangavelu, G., Du, J., Paz, K. G., Loschi, M., Zaiken, M. C., Flynn, R., Taylor, P. A., Kirchmeier, A. K., Panoskaltsis-Mortari, A., Luznik, L., MacDonald, K. P., Hill, G. R., Maillard, I., Munn, D. H., Serody, J. S., Murphy, W. J., Miklos, D., Cutler, C. S., Koreth, J., Antin, J. H. & 5 others, Soiffer, R. J., Ritz, J., Dahlberg, C., Miller, A. T. & Blazar, B. R., Jan 1 2020, In : Blood. 135, 1, p. 28-40 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Minimal PD-1 expression in mouse and human NK cells under diverse conditions

Judge, S. J., Dunai, C., Aguilar, E. G., Vick, S. C., Sturgill, I. R., Khuat, L. T., Stoffel, K. M., Van Dyke, J., Longo, D. L., Darrow, M. A., Anderson, S. K., Blazar, B. R., Monjazeb, A. M., Serody, J. S., Canter, R. J. & Murphy, W. J., Jun 1 2020, In : Journal of Clinical Investigation. 130, 6, p. 3051-3068 18 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2019

Bortezomib augments natural killer cell targeting of stem-like tumor cells

Luna, J. I., Grossenbacher, S. K., Sturgill, I. R., Ames, E., Judge, S. J., Bouzid, L. A., Darrow, M., Murphy, W. J. & Canter, R. J., Jan 1 2019, In : Cancers. 11, 1, 85.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD

Koehn, B. H., Saha, A., McDonald-Hyman, C., Loschi, M., Thangavelu, G., Ma, L., Zaiken, M., Dysthe, J., Krepps, W., Panthera, J., Hippen, K., Jameson, S. C., Miller, J. S., Cooper, M. A., Farady, C. J., Iwawaki, T., Ting, J. P. Y., Serody, J. S., Murphy, W. J., Hill, G. R. & 5 others, Murray, P. J., Bronte, V., Munn, D. H., Zeiser, R. & Blazar, B. R., Nov 7 2019, In : Blood. 134, 19, p. 1670-1682 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality

Thangavelu, G., Lee, Y. C., Loschi, M., Schaechter, K. M., Feser, C. J., Koehn, B. H., Nowak, E. C., Zeiser, R., Serody, J. S., Murphy, W. J., Munn, D. H., Chambon, P., Noelle, R. J. & Blazar, B. R., May 1 2019, In : Journal of immunology (Baltimore, Md. : 1950). 202, 9, p. 2795-2805 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality

Saha, A., Taylor, P. A., Lees, C. J., Panoskaltsis-Mortari, A., Osborn, M. J., Feser, C. J., Thangavelu, G., Melchinger, W., Refaeli, Y., Hill, G. R., Munn, D. H., Murphy, W. J., Serody, J. S., Maillard, I., Kreymborg, K., van den Brink, M., Dong, C., Huang, S., Zang, X., Allison, J. P. & 2 others, Zeiser, R. & Blazar, B. R., Jan 1 2019, In : JCI Insight. 4, 19, e127716.

Research output: Contribution to journalArticle

4 Scopus citations
Open Access
1 Scopus citations

Regulation of murine NK cell exhaustion through the activation of the DNA damage repair pathway

Alvarez, M., Simonetta, F., Baker, J., Pierini, A., Wenokur, A. S., Morrison, A. R., Murphy, W. J. & Negrin, R. S., Jan 1 2019, In : JCI Insight. 4, 14, e127729.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease

Paz, K., Flynn, R., Du, J., Qi, J., Luznik, L., Maillard, I., MacDonald, K. P., Hill, G. R., Serody, J. S., Murphy, W. J., Sage, P. T., Sharpe, A. H., Miklos, D., Cutler, C. S., Koreth, J., Antin, J. H., Soiffer, R. J., Ritz, J., Bradner, J. E., Melnick, A. M. & 1 others, Blazar, B. R., Jan 3 2019, In : Blood. 133, 1, p. 94-99 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease

Paz, K., Flynn, R., Du, J., Tannheimer, S., Johnson, A. J., Dong, S., Stark, A. K., Okkenhaug, K., Panoskaltsis-Mortari, A., Sage, P. T., Sharpe, A. H., Luznik, L., Ritz, J., Soiffer, R. J., Cutler, C. S., Koreth, J., Antin, J. H., Miklos, D. B., MacDonald, K. P., Hill, G. R. & 10 others, Maillard, I., Serody, J. S., Murphy, W. J., Munn, D. H., Feser, C., Zaiken, M., Vanhaesebroeck, B., Turka, L. A., Byrd, J. C. & Blazar, B. R., Jan 1 2019, In : American Journal of Transplantation.

Research output: Contribution to journalArticle

2 Scopus citations

The complicated effects of obesity on cancer and immunotherapy

Wang, Z., Monjazeb, A. M. & Murphy, W. J., Jan 1 2019, In : Immunotherapy. 11, 1, p. 11-14 4 p.

Research output: Contribution to journalReview article

5 Scopus citations

The Surprisingly Positive Association between Obesity and Cancer Immunotherapy Efficacy

Murphy, W. J. & Longo, D. L., Apr 2 2019, In : JAMA - Journal of the American Medical Association. 321, 13, p. 1247-1248 2 p.

Research output: Contribution to journalShort survey

Open Access
16 Scopus citations
2018

Alterations in cancer stem-cell marker CD44 expression predict oncologic outcome in soft-tissue sarcomas

Henderson, T., Chen, M., Darrow, M., Li, C-S., Chiu, C. L., Monjazeb, A. M., Murphy, W. J. & Canter, R. J., Mar 1 2018, In : Journal of Surgical Research. 223, p. 207-214 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2 Scopus citations

Applications and efficiencies of the first cat 63K DNA array

Gandolfi, B., Alhaddad, H., Abdi, M., Bach, L. H., Creighton, E. K., Davis, B. W., Decker, J. E., Dodman, N. H., Grahn, J. C., Grahn, R. A., Haase, B., Haggstrom, J., Hamilton, M. J., Helps, C. R., Kurushima, J. D., Lohi, H., Longeri, M., Malik, R., Meurs, K. M., Montague, M. J. & 11 others, Mullikin, J. C., Murphy, W. J., Nilson, S. M., Pedersen, N. C., Peterson, C. B., Rusbridge, C., Saif, R., Shelton, D. G., Warren, W. C., Wasim, M. & Lyons, L. A., Jan 1 2018, In : Scientific Reports. 8, 1

Research output: Contribution to journalArticle

11 Scopus citations

Association of macrophage and lymphocyte infiltration with outcome in canine osteosarcoma

Withers, S. S., Skorupski, K. A., York, D., Choi, J. W., Woolard, K. D., Laufer-Amorim, R., Sparger, E. E., Rodriguez, C. O., McSorley, S. J., Monjazeb, A. M., Murphy, W. J., Canter, R. J. & Rebhun, R. B., Jan 1 2018, (Accepted/In press) In : Veterinary and Comparative Oncology.

Research output: Contribution to journalArticle

8 Scopus citations

Author Correction: Applications and efficiencies of the first cat 63K DNA array (Scientific Reports DOI: 10.1038/s41598-018-25438-0)

Gandolfi, B., Alhaddad, H., Abdi, M., Bach, L. H., Creighton, E. K., Davis, B. W., Decker, J. E., Dodman, N. H., Grahn, J. C., Grahn, R. A., Haase, B., Haggstrom, J., Hamilton, M. J., Helps, C. R., Kurushima, J. D., Lohi, H., Longeri, M., Malik, R., Meurs, K. M., Montague, M. J. & 11 others, Mullikin, J. C., Murphy, W. J., Nilson, S. M., Pedersen, N. C., Peterson, C. B., Rusbridge, C., Saif, R., Shelton, G. D., Warren, W. C., Wasim, M. & Lyons, L. A., Dec 1 2018, In : Scientific Reports. 8, 1, 8746.

Research output: Contribution to journalComment/debate

Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation

Chavez, M., Silvestrini, M. T., Ingham, E. S., Fite, B. Z., Mahakian, L. M., Tam, S. M., Ilovitsh, A., Monjazeb, A. M., Murphy, W. J., Hubbard, N. E., Davis, R. R., Tepper, C. G., Borowsky, A. D. & Ferrara, K. W., Jan 1 2018, In : Theranostics. 8, 13, p. 3611-3628 18 p.

Research output: Contribution to journalArticle

14 Scopus citations

Donor HSCs with a preexisting ASXL1-mutation led to the development of FLT3-ITD positive AML in the donor and FLT3-ITD negative AML in the recipient after unrelated transplant

Liu, Z., Liu, H., Shi, M., Ahmed, H. A. W., Huo, L., Zhang, Y., Kong, D., Wen, M., Wang, F., Chen, M., Murphy, W. J. & Sun, K., Apr 1 2018, In : Bone Marrow Transplantation. 53, 4, p. 499-502 4 p.

Research output: Contribution to journalLetter

6 Scopus citations

Making a better hematopoietic stem cell - Timing is everything

Murphy, W. J., Jan 4 2018, In : New England Journal of Medicine. 378, 1, p. 89-91 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Multi-color flow cytometry for evaluating age-related changes in memory lymphocyte subsets in dogs

Withers, S. S., Moore, P. F., Chang, H., Choi, J. W., McSorley, S. J., Kent, M. S., Monjazeb, A. M., Canter, R. J., Murphy, W. J., Sparger, E. E. & Rebhun, R. B., Oct 1 2018, In : Developmental and Comparative Immunology. 87, p. 64-74 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

NK cells for PD-1/PD-L1 blockade immunotherapy: Pinning down the NK cell

Dunai, C. & Murphy, W. J., Oct 1 2018, In : Journal of Clinical Investigation. 128, 10, p. 4251-4253 3 p.

Research output: Contribution to journalReview article

5 Scopus citations

Obesity as an immune-modifying factor in cancer immunotherapy

Canter, R. J., Le, C. T., Beerthuijzen, J. M. T. & Murphy, W. J., Sep 1 2018, In : Journal of Leukocyte Biology. 104, 3, p. 487-497 11 p.

Research output: Contribution to journalReview article

5 Scopus citations

Obesity induced T cell dysfunction and implications for cancer immunotherapy

Aguilar, E. G. & Murphy, W. J., Apr 1 2018, In : Current Opinion in Immunology. 51, p. 181-186 6 p.

Research output: Contribution to journalReview article

12 Scopus citations

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Wang, Z., Aguilar, E. G., Luna, J. I., Dunai, C., Khuat, L. T., Le, C. T., Mirsoian, A., Minnar, C. M., Stoffel, K. M., Sturgill, I. R., Grossenbacher, S. K., Withers, S. S., Rebhun, R. B., Hartigan-O'Connor, D., Méndez-Lagares, G., Tarantal, A. F., Isseroff, R. R., Griffith, T. S., Schalper, K. A., Merleev, A. & 13 others, Saha, A., Maverakis, E. M., Kelly, K., Aljumaily, R., Ibrahimi, S., Mukherjee, S., Machiorlatti, M., Vesely, S. K., Longo, D. L., Blazar, B. R., Canter, R. J., Murphy, W. J. & Monjazeb, A. M., Jan 1 2018, (Accepted/In press) In : Nature Medicine.

Research output: Contribution to journalArticle

87 Scopus citations
15 Scopus citations
2017

Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy

Sckisel, G. D., Mirsoian, A., Minnar, C. M., Crittenden, M., Curti, B., Chen, J. Q., Blazar, B. R., Borowsky, A. D., Monjazeb, A. M. & Murphy, W. J., Apr 18 2017, In : Journal for ImmunoTherapy of Cancer. 5, 1, 33.

Research output: Contribution to journalArticle

9 Scopus citations

Human and feline adipose-derived mesenchymal stem cells have comparable phenotype, immunomodulatory functions, and transcriptome

Clark, K. C., Fierro, F. A., Ko, E. M., Walker, N. J., Arzi, B., Tepper, C. G., Dahlenburg, H., Cicchetto, A., Kol, A., Marsh, L., Murphy, W. J., Fazel, N. & Borjesson, D. L., Mar 20 2017, In : Stem Cell Research and Therapy. 8, 1, 69.

Research output: Contribution to journalArticle

20 Scopus citations

Leveraging natural killer cells for cancer immunotherapy

Grossenbacher, S. K., Aguilar, E. G. & Murphy, W. J., May 1 2017, In : Immunotherapy. 9, 6, p. 487-497 11 p.

Research output: Contribution to journalReview article

18 Scopus citations

Licensing delineates helper and effector NK cell subsets during viral infection

Zamora, A. E., Aguilar, E. G., Sungur, C. M., Khuat, L. T., Dunai, C., Lochhead, G. R., Du, J., Pomeroy, C., Blazar, B. R., Longo, D. L., Venstrom, J. M., Baumgarth, N. & Murphy, W. J., May 18 2017, In : JCI insight. 2, 10

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Priming is key to effective incorporation of image-guided thermal ablation into immunotherapy protocols

Silvestrini, M. T., Ingham, E. S., Mahakian, L. M., Kheirolomoom, A., Liu, Y., Fite, B. Z., Tam, S. M., Tucci, S. T., Watson, K. D., Wong, A. W., Monjazeb, A. M., Hubbard, N. E., Murphy, W. J., Borowsky, A. D. & Ferrara, K. W., Mar 23 2017, In : JCI insight. 2, 6, p. e90521

Research output: Contribution to journalArticle

31 Scopus citations

Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial

Canter, R. J., Grossenbacher, S. K., Foltz, J. A., Sturgill, I. R., Park, J. S., Luna, J. I., Kent, M. S., Culp, W. T., Chen, M., Modiano, J. F., Monjazeb, A. M., Lee, D. A. & Murphy, W. J., Dec 19 2017, In : Journal for ImmunoTherapy of Cancer. 5, 1, 98.

Research output: Contribution to journalArticle

30 Scopus citations

Stimulating Innate Immunity to Enhance Radiation Therapy–Induced Tumor Control

Baird, J. R., Monjazeb, A. M., Shah, O., McGee, H., Murphy, W. J., Crittenden, M. R. & Gough, M. J., Oct 1 2017, In : International Journal of Radiation Oncology Biology Physics. 99, 2, p. 362-373 12 p.

Research output: Contribution to journalReview article

23 Scopus citations

Targeting Cancer Stem Cells with Natural Killer Cell Immunotherapy

Luna, J. I., Grossenbacher, S. K., Murphy, W. J. & Canter, R. J., Mar 4 2017, In : Expert Opinion on Biological Therapy. 17, 3, p. 313-324 12 p.

Research output: Contribution to journalReview article

30 Scopus citations

The proportion of circulating CD45RO+CD8+ memory T cells is correlated with clinical response in melanoma patients treated with ipilimumab

Tietze, J. K., Angelova, D., Heppt, M. V., Reinholz, M., Murphy, W. J., Spannagl, M., Ruzicka, T. & Berking, C., Apr 1 2017, In : European Journal of Cancer. 75, p. 268-279 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Therapeutic Effects of a NEDD8-Activating Enzyme Inhibitor, Pevonedistat, on Sclerodermatous Graft-versus-Host Disease in Mice

Pai, C. C. S., Khuat, L. T., Chen, M., Murphy, W. J. & Abedi, M., Jan 1 2017, In : Biology of Blood and Marrow Transplantation. 23, 1, p. 30-37 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Therapeutic efficacy of fresh, allogeneic mesenchymal stem cells for severe refractory feline chronic gingivostomatitis

Arzi, B., Clark, K. C., Sundaram, A., Spriet, M., Verstraete, F. J., Walker, N. J., Loscar, M. R., Fazel, N., Murphy, W. J., Vapniarsky Arzi, N. & Borjesson, D. L., Aug 1 2017, In : Stem cells translational medicine. 6, 8, p. 1710-1722 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Western Diet–Induced Dysbiosis in Farnesoid X Receptor Knockout Mice Causes Persistent Hepatic Inflammation after Antibiotic Treatment

Jena, P. K., Sheng, L., Liu, H. X., Kalanetra, K. M., Mirsoian, A., Murphy, W. J., French, S. W., Krishnan, V. V., Mills, D. A. & Wan, Y-J. Y., Aug 1 2017, In : American Journal of Pathology. 187, 8, p. 1800-1813 14 p.

Research output: Contribution to journalArticle

32 Scopus citations
2016
3 Scopus citations

Blocking indolamine-2,3-dioxygenase rebound immune suppression boosts antitumor effects of radio-immunotherapy in murine models and spontaneous canine malignancies

Monjazeb, A. M., Kent, M. S., Grossenbacher, S. K., Mall, C., Zamora, A. E., Mirsoian, A., Chen, M., Kol, A., Shiao, S. L., Reddy, A., Perks, J. R., Culp, W. T., Sparger, E. E., Canter, R. J., Sckisel, G. D. & Murphy, W. J., Sep 1 2016, In : Clinical Cancer Research. 22, 17, p. 4328-4340 13 p.

Research output: Contribution to journalArticle

48 Scopus citations

Canine cancer immunotherapy studies: Linking mouse and human

Park, J. S., Withers, S. S., Modiano, J. F., Kent, M. S., Chen, M., Luna, J. I., Culp, W. T., Sparger, E. E., Rebhun, R. B., Monjazeb, A. M., Murphy, W. J. & Canter, R. J., Dec 20 2016, In : Journal for ImmunoTherapy of Cancer. 4, 1, 97.

Research output: Contribution to journalReview article

35 Scopus citations

High fluence light emitting diode-generated red light modulates characteristics associated with skin fibrosis

Mamalis, A., Koo, E., Garcha, M., Murphy, W. J., Isseroff, R. R. & Jagdeo, J., 2016, (Accepted/In press) In : Journal of Biophotonics.

Research output: Contribution to journalArticle

12 Scopus citations

Immune targeting of cancer stem cells in gastrointestinal oncology

Canter, R. J., Grossenbacher, S. K., Ames, E. & Murphy, W. J., Apr 1 2016, In : Journal of Gastrointestinal Oncology. 7, p. S1-S10

Research output: Contribution to journalReview article

14 Scopus citations

Immunoregulatory pathways following strong inflammatory processes markedly impair CD4+ T cell responses

Minnar, C. M. & Murphy, W. J., Sep 1 2016, In : Human Vaccines and Immunotherapeutics. 12, 9, p. 2249-2252 4 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

LRIG1 opposes epithelial-To-mesenchymal transition and inhibits invasion of basal-like breast cancer cells

Yokdang, N., Hatakeyama, J., Wald, J. H., Simion, C., Tellez, J. D., Chang, D. Z., Swamynathan, M. M., Chen, M., Murphy, W. J., Carraway, K. L. & Sweeney, C. A., Jun 2 2016, In : Oncogene. 35, 22, p. 2932-2947 16 p.

Research output: Contribution to journalArticle

22 Scopus citations