4-(Isoxazol-3-yl)pyrimidines from pyrimidinyl nitrile oxides

Wonken Choung, Beth A. Lorsbach, Thomas C. Sparks, James M. Ruiz, Mark J. Kurth

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The 1,3-dipolar cycloaddition reaction of pyrimidinylaldoxime derived nitrile oxides and alkynes delivers 4-(isoxazol-3-yl)pyrimidines. The procedures reported accommodate three points of diversification around this bisheterocyclic scaffold and the resulting library of compounds has been added to the National Institutes of Health repository (ca. 10 mg of each with >90% purity) for pilot-scale biomedical studies with bioassay data available at the National Center for Biotechnology Information PubChem database.

Original languageEnglish (US)
Pages (from-to)3036-3040
Number of pages5
JournalSynlett
Issue number19
DOIs
StatePublished - Dec 1 2008

Keywords

  • 2-aminopyrimidine
  • Cycloaddition
  • ipso substitution
  • Isoxazoles
  • Isoxazolines
  • Nitrile oxide

ASJC Scopus subject areas

  • Organic Chemistry

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  • Cite this

    Choung, W., Lorsbach, B. A., Sparks, T. C., Ruiz, J. M., & Kurth, M. J. (2008). 4-(Isoxazol-3-yl)pyrimidines from pyrimidinyl nitrile oxides. Synlett, (19), 3036-3040. https://doi.org/10.1055/s-0028-1087346