3D-printed breast phantom for multi-purpose and multi-modality imaging

Yaoyao He, Yulin Liu, Brandon A. Dyer, John M Boone, Shanshan Liu, Tiao Chen, Fenglian Zheng, Ye Zhu, Yong Sun, Yi Rong, Jianfeng Qiu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Breast imaging technology plays an important role in breast cancer planning and treatment. Recently, three-dimensional (3D) printing technology has become a trending issue in phantom constructions for medical applications, with its advantages of being customizable and cost-efficient. However, there is no current practice in the field of multi-purpose breast phantom for quality control (QC) in multi-modalities imaging. The purpose of this study was to fabricate a multi-purpose breast phantom with tissue-equivalent materials via a 3D printing technique for QC in multi-modalities imaging. Methods: We used polyvinyl chloride (PVC) based materials and a 3D printing technique to construct a breast phantom. The phantom incorporates structures imaged in the female breast such as microcalcifications, fiber lesions, and tumors with different sizes. Moreover, the phantom was used to assess the sensitivity of lesion detection, depth resolution, and detectability thresholds with different imaging modalities. Phantom tissue equivalent properties were determined using computed tomography (CT) attenuation [Hounsfield unit (HU)] and magnetic resonance imaging (MRI) relaxation times. Results: The 3D-printed breast phantom had an average background value of 36.2 HU, which is close to that of glandular breast tissue (40 HU). T1 and T2 relaxation times had an average relaxation time of 206.81±17.50 and 20.22±5.74 ms, respectively. Mammographic imaging had improved detection of microcalcification compared with ultrasound and MRI with multiple sequences [T1WI, T2WI and short inversion time inversion recovery (STIR)]. Soft-tissue lesion detection and cylindrical tumor contrast were superior with mammography and MRI compared to ultrasound. Hemispherical tumor detection was similar regardless of the imaging modality used. Conclusions: We developed a multi-purpose breast phantom using a 3D printing technique and determined its value for multi-modal breast imaging studies.

Original languageEnglish (US)
Pages (from-to)63-74
Number of pages12
JournalQuantitative Imaging in Medicine and Surgery
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Breast
Calcinosis
Magnetic Resonance Imaging
Quality Control
Technology
Neoplasms
Mammography
Polyvinyl Chloride
Tomography
Three Dimensional Printing
Breast Neoplasms
Costs and Cost Analysis

Keywords

  • 3D printing
  • Breast phantom
  • Magnetic resonance imaging (MRI)
  • Mammography
  • Polyvinyl chloride (PVC)
  • Ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

3D-printed breast phantom for multi-purpose and multi-modality imaging. / He, Yaoyao; Liu, Yulin; Dyer, Brandon A.; Boone, John M; Liu, Shanshan; Chen, Tiao; Zheng, Fenglian; Zhu, Ye; Sun, Yong; Rong, Yi; Qiu, Jianfeng.

In: Quantitative Imaging in Medicine and Surgery, Vol. 9, No. 1, 01.01.2019, p. 63-74.

Research output: Contribution to journalArticle

He, Yaoyao ; Liu, Yulin ; Dyer, Brandon A. ; Boone, John M ; Liu, Shanshan ; Chen, Tiao ; Zheng, Fenglian ; Zhu, Ye ; Sun, Yong ; Rong, Yi ; Qiu, Jianfeng. / 3D-printed breast phantom for multi-purpose and multi-modality imaging. In: Quantitative Imaging in Medicine and Surgery. 2019 ; Vol. 9, No. 1. pp. 63-74.
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AU - Liu, Yulin

AU - Dyer, Brandon A.

AU - Boone, John M

AU - Liu, Shanshan

AU - Chen, Tiao

AU - Zheng, Fenglian

AU - Zhu, Ye

AU - Sun, Yong

AU - Rong, Yi

AU - Qiu, Jianfeng

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AB - Background: Breast imaging technology plays an important role in breast cancer planning and treatment. Recently, three-dimensional (3D) printing technology has become a trending issue in phantom constructions for medical applications, with its advantages of being customizable and cost-efficient. However, there is no current practice in the field of multi-purpose breast phantom for quality control (QC) in multi-modalities imaging. The purpose of this study was to fabricate a multi-purpose breast phantom with tissue-equivalent materials via a 3D printing technique for QC in multi-modalities imaging. Methods: We used polyvinyl chloride (PVC) based materials and a 3D printing technique to construct a breast phantom. The phantom incorporates structures imaged in the female breast such as microcalcifications, fiber lesions, and tumors with different sizes. Moreover, the phantom was used to assess the sensitivity of lesion detection, depth resolution, and detectability thresholds with different imaging modalities. Phantom tissue equivalent properties were determined using computed tomography (CT) attenuation [Hounsfield unit (HU)] and magnetic resonance imaging (MRI) relaxation times. Results: The 3D-printed breast phantom had an average background value of 36.2 HU, which is close to that of glandular breast tissue (40 HU). T1 and T2 relaxation times had an average relaxation time of 206.81±17.50 and 20.22±5.74 ms, respectively. Mammographic imaging had improved detection of microcalcification compared with ultrasound and MRI with multiple sequences [T1WI, T2WI and short inversion time inversion recovery (STIR)]. Soft-tissue lesion detection and cylindrical tumor contrast were superior with mammography and MRI compared to ultrasound. Hemispherical tumor detection was similar regardless of the imaging modality used. Conclusions: We developed a multi-purpose breast phantom using a 3D printing technique and determined its value for multi-modal breast imaging studies.

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KW - Ultrasound

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