3D OCT imaging in clinical settings: Toward quantitative measurements of retinal structures

Robert Zawadzki, Alfred R. Fuller, Mingtao Zhao, David F. Wiley, Stacey S. Choi, Bradley A. Bower, Bernd Hamann, Joseph A. Izatt, John S Werner

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

The acquisition speed of current FD-OCT (Fourier Domain - Optical Coherence Tomography) instruments allows rapid screening of three-dimensional (3D) volumes of human retinas in clinical settings. To take advantage of this ability requires software used by physicians to be capable of displaying and accessing volumetric data as well as supporting post processing in order to access important quantitative information such as thickness maps and segmented volumes. We describe our clinical FD-OCT system used to acquire 3D data from the human retina over the macula and optic nerve head. B-scans are registered to remove motion artifacts and post-processed with customized 3D visualization and analysis software. Our analysis software includes standard 3D visualization techniques along with a machine learning support vector machine (SVM) algorithm that allows a user to semi-automatically segment different retinal structures and layers. Our program makes possible measurements of the retinal layer thickness as well as volumes of structures of interest, despite the presence of noise and structural deformations associated with retinal pathology. Our software has been tested successfully in clinical settings for its efficacy in assessing 3D retinal structures in healthy as well as diseased cases. Our tool facilitates diagnosis and treatment monitoring of retinal diseases.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6138
DOIs
StatePublished - 2006
EventOphthalmic Technologies XVI - San Jose, CA, United States
Duration: Jan 21 2006Jan 24 2006

Other

OtherOphthalmic Technologies XVI
CountryUnited States
CitySan Jose, CA
Period1/21/061/24/06

Keywords

  • Feature Finding
  • Image Processing
  • Ophthalmology
  • Optical Coherence Tomography
  • Optical Diagnostic for Medicine
  • Segmentation

ASJC Scopus subject areas

  • Engineering(all)

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