3D hyperpolarized He-3 MRI of ventilation using a multi-echo projection acquisition

James H. Holmes, Rafael L. O'Halloran, Ethan K. Brodsky, Youngkyoo Jung, Walter F. Block, Sean B. Fain

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

A method is presented for high-resolution 3D imaging of the whole lung using inhaled hyperpolarized (HP) He-3 MR with multiple half-echo radial trajectories that can accelerate imaging through undersampling. A multiple half-echo radial trajectory can be used to reduce the level of artifact for under-sampled 3D projection reconstruction (PR) imaging by increasing the amount of data acquired per unit time for HP He-3 lung imaging. The point spread functions (PSFs) for breath-held He-3 MRI using multiple half-echo trajectories were evaluated using simulations to predict the effects of T2* and gas diffusion on image quality. Results from PSF simulations were consistent with imaging results in volunteer studies showing improved image quality with increasing number of echoes using up to 8 half-echoes. The 8-half-echo acquisition is shown to accommodate lost breath-holds as short as 6 sec using a retrospective reconstruction at reduced resolution and also to allow reduced breath-hold time compared with an equivalent Cartesian trajectory. Furthermore, preliminary results from a 3D dynamic inhalation-exhalation maneuver are demonstrated using the 8-half-echo trajectory. Results demonstrate the first high-resolution 3D PR imaging of ventilation and respiratory dynamics in humans using HP He-3 MR.

Original languageEnglish (US)
Pages (from-to)1062-1071
Number of pages10
JournalMagnetic Resonance in Medicine
Volume59
Issue number5
DOIs
StatePublished - May 1 2008
Externally publishedYes

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Ventilation
Exhalation
Lung
Artifacts
Inhalation
Volunteers
Gases

Keywords

  • Hyperpolarized helium-3
  • Lung
  • Multi-echo
  • Radial projection acquisition
  • Ventilation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Holmes, J. H., O'Halloran, R. L., Brodsky, E. K., Jung, Y., Block, W. F., & Fain, S. B. (2008). 3D hyperpolarized He-3 MRI of ventilation using a multi-echo projection acquisition. Magnetic Resonance in Medicine, 59(5), 1062-1071. https://doi.org/10.1002/mrm.21437

3D hyperpolarized He-3 MRI of ventilation using a multi-echo projection acquisition. / Holmes, James H.; O'Halloran, Rafael L.; Brodsky, Ethan K.; Jung, Youngkyoo; Block, Walter F.; Fain, Sean B.

In: Magnetic Resonance in Medicine, Vol. 59, No. 5, 01.05.2008, p. 1062-1071.

Research output: Contribution to journalArticle

Holmes, JH, O'Halloran, RL, Brodsky, EK, Jung, Y, Block, WF & Fain, SB 2008, '3D hyperpolarized He-3 MRI of ventilation using a multi-echo projection acquisition', Magnetic Resonance in Medicine, vol. 59, no. 5, pp. 1062-1071. https://doi.org/10.1002/mrm.21437
Holmes, James H. ; O'Halloran, Rafael L. ; Brodsky, Ethan K. ; Jung, Youngkyoo ; Block, Walter F. ; Fain, Sean B. / 3D hyperpolarized He-3 MRI of ventilation using a multi-echo projection acquisition. In: Magnetic Resonance in Medicine. 2008 ; Vol. 59, No. 5. pp. 1062-1071.
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