3D Diffusion Tensor MRI With Isotropic Resolution Using a Steady-State Radial Acquisition

Youngkyoo Jung, Alexey A. Samsonov, Walter F. Block, Mariana Lazar, Aiming Lu, Jing Liu, Andrew L. Alexander

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Purpose: To obtain diffusion tensor images (DTI) over a large image volume rapidly with 3D isotropic spatial reso- lution, minimal spatial distortions, and reduced motion artifacts, a diffusion-weighted steady-state 3D projection (SS 3DPR) pulse sequence was developed. Materials and Methods: A diffusion gradient was inserted in a SS 3DPR pulse sequence. The acquisition was synchro- nized to the cardiac cycle, linear phase errors were cor- rected along the readout direction, and each projection was weighted by measures of consistency with other data. A new iterative parallel imaging reconstruction method was also implemented for removing off-resonance and under- sampling artifacts simultaneously. Results: The contrast and appearance of both the frac- tional anisotropy and eigenvector color maps were substan- tially improved after all correction techniques were applied. True 3D DTI datasets were obtained in vivo over the whole brain (240 mm field of view in all directions) with 1.87 mm isotropic spatial resolution, six diffusion encoding direc- tions in under 19 minutes. Conclusion: A true 3D DTI pulse sequence with high iso- tropic spatial resolution was developed for whole brain im- aging in under 20 minutes.

Original languageEnglish (US)
Pages (from-to)1175-1184
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Issue number5
StatePublished - May 1 2009


  • 3D imaging
  • Diffusion tensor imaging
  • Radial acquisition
  • Steady state

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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