3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI

Liana G. Apostolova, Paul M. Thompson, Amity E. Green, Kristy S. Hwang, Charleen Zoumalan, Clifford R. Jack, Danielle J Harvey, Ronald C. Petersen, Leon J. Thal, Paul S. Aisen, Arthur W. Toga, Jeffrey L. Cummings, Charles DeCarli

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

We applied the hippocampal radial atrophy mapping technique to the baseline and follow-up magnetic resonance image data of 169 amnestic mild cognitive impairment (MCI) participants in the imaging arm of the Alzheimer's Disease Cooperative Study MCI Donepezil/Vitamin E trial. Sixty percent of the subjects with none to mild hippocampal atrophy rated with the visual medial temporal atrophy rating scale (MTA score < 2) and 33.8% of the subjects with moderate to severe (MTA ≥ 2) hippocampal atrophy converted to Alzheimer's disease (AD) during 3-year follow-up. MTA ≥ 2 showed a trend for greater left sided hippocampal atrophy versus MTA < 2 groups at baseline (Pcorrected = 0.08). Higher MTA scores were associated with progressive atrophy of the subiculum and the CA1-3 subregions. The MTA < 2 group demonstrated significant bilateral atrophy progression at follow-up (left P corrected = 0.008; right Pcorrected = 0.05). Relative to MTA < 2 nonconverters, MTA < 2 converters showed further involvement of the subiculum and CA1 and additional involvement of CA2-3 at follow-up. Right CA1 atrophy was significantly associated with conversion to dementia (for 1 mm greater right CA1 radial distance subjects had 50% reduced hazard for conversion). Greater CA1 and subicular atrophy can be demonstrated early and is predictive of future conversion to AD, whereas CA2-3 involvement becomes more evident as the disease progresses.

Original languageEnglish (US)
Pages (from-to)786-797
Number of pages12
JournalHuman Brain Mapping
Volume31
Issue number5
DOIs
StatePublished - May 2010

Keywords

  • Conversion
  • Hippocampal atrophy
  • Imaging biomarker
  • Magnetic resonance imaging
  • Medial temporal atrophy
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Fingerprint Dive into the research topics of '3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI'. Together they form a unique fingerprint.

Cite this