31P and 3-fluoro-3-deoxy-D-glucose 19F in vivo NMR spectroscopy of aged rat brain.

Ingrid Kwee, T. Nakada, N. Suzuki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

31P and 3-fluoro-3-deoxy-D-glucose (3-FDG) 19F nuclear magnetic resonance (NMR) spectroscopic investigations were performed on aged rat brain in vivo. Phosphodiester (PDE) was found to be significantly higher (p less than 0.05) in aged brain (18 months, n = 10) than adult controls (6 months, n = 10) suggesting accelerated phospholipid catabolism in aged brain. Inorganic phosphate (Pi) levels were significantly lower (p less than 0.05) in aged brain (n = 5) than in normal adult controls (n = 5). The sorbitol index, a measure of aldose reductase activities in vivo, determined by the 3-FDG 19F NMR method, revealed that aldose reductase activities were significantly higher (p less than 0.05) in aged brain.

Original languageEnglish (US)
Pages (from-to)38-40
Number of pages3
JournalNMR in Biomedicine
Volume4
Issue number1
StatePublished - Feb 1991

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Nuclear magnetic resonance spectroscopy
Rats
Brain
Magnetic Resonance Spectroscopy
Aldehyde Reductase
Nuclear magnetic resonance
Sorbitol
Phospholipids
Phosphates
3-deoxy-3-fluoro-D-glucose

ASJC Scopus subject areas

  • Biophysics
  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

31P and 3-fluoro-3-deoxy-D-glucose 19F in vivo NMR spectroscopy of aged rat brain. / Kwee, Ingrid; Nakada, T.; Suzuki, N.

In: NMR in Biomedicine, Vol. 4, No. 1, 02.1991, p. 38-40.

Research output: Contribution to journalArticle

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