3% NaCl and 7.5% NaCl/dextran 70 in the resuscitation of severely injured patients

James W Holcroft, M. J. Vassar, J. E. Turner, R. W. Derlet, G. C. Kramer

Research output: Contribution to journalArticle

200 Citations (Scopus)

Abstract

Cardiovascular resuscitation of the severely injured patient in the field reamins unsatisfactory because large volumes of intravenous fluid are needed to keep up with ongoing blood losses and because only small volumes of fluid can be given. In the first study reported here, small volumes (≤12 mL/kg) of 3% NaCl were given to patients who were having surgery for severe injuries. The 3% NaCl restored blood pressure, pH, and urine output with approximately one half of the cumulative fluid requirement of patients who received isotonic fluids (p < 0.05). In a second study, 7.5% NaCl/dextran 70, 250 mL, was given in a prospective, randomized, and double-blinded trial to injured patients in the field. Blood pressure in the hypertonic/hyperoncotic group increased 49 mmHg during transport (p<0.005); blood pressure in patients given lactated Ringer's solution increased 19 mmHg (NS). Survival favored the hypertonic/hyperoncotic group. The 7.5% of NaCl/dextran 70 solution appears particularly promising for treatment of injured patients in the field

Original languageEnglish (US)
Pages (from-to)279-288
Number of pages10
JournalAnnals of Surgery
Volume206
Issue number3
StatePublished - 1987

Fingerprint

Dextrans
Resuscitation
Blood Pressure
Urine
Survival
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery

Cite this

Holcroft, J. W., Vassar, M. J., Turner, J. E., Derlet, R. W., & Kramer, G. C. (1987). 3% NaCl and 7.5% NaCl/dextran 70 in the resuscitation of severely injured patients. Annals of Surgery, 206(3), 279-288.

3% NaCl and 7.5% NaCl/dextran 70 in the resuscitation of severely injured patients. / Holcroft, James W; Vassar, M. J.; Turner, J. E.; Derlet, R. W.; Kramer, G. C.

In: Annals of Surgery, Vol. 206, No. 3, 1987, p. 279-288.

Research output: Contribution to journalArticle

Holcroft, JW, Vassar, MJ, Turner, JE, Derlet, RW & Kramer, GC 1987, '3% NaCl and 7.5% NaCl/dextran 70 in the resuscitation of severely injured patients', Annals of Surgery, vol. 206, no. 3, pp. 279-288.
Holcroft, James W ; Vassar, M. J. ; Turner, J. E. ; Derlet, R. W. ; Kramer, G. C. / 3% NaCl and 7.5% NaCl/dextran 70 in the resuscitation of severely injured patients. In: Annals of Surgery. 1987 ; Vol. 206, No. 3. pp. 279-288.
@article{4a64c41bc09745c3930a21a730aea6ce,
title = "3{\%} NaCl and 7.5{\%} NaCl/dextran 70 in the resuscitation of severely injured patients",
abstract = "Cardiovascular resuscitation of the severely injured patient in the field reamins unsatisfactory because large volumes of intravenous fluid are needed to keep up with ongoing blood losses and because only small volumes of fluid can be given. In the first study reported here, small volumes (≤12 mL/kg) of 3{\%} NaCl were given to patients who were having surgery for severe injuries. The 3{\%} NaCl restored blood pressure, pH, and urine output with approximately one half of the cumulative fluid requirement of patients who received isotonic fluids (p < 0.05). In a second study, 7.5{\%} NaCl/dextran 70, 250 mL, was given in a prospective, randomized, and double-blinded trial to injured patients in the field. Blood pressure in the hypertonic/hyperoncotic group increased 49 mmHg during transport (p<0.005); blood pressure in patients given lactated Ringer's solution increased 19 mmHg (NS). Survival favored the hypertonic/hyperoncotic group. The 7.5{\%} of NaCl/dextran 70 solution appears particularly promising for treatment of injured patients in the field",
author = "Holcroft, {James W} and Vassar, {M. J.} and Turner, {J. E.} and Derlet, {R. W.} and Kramer, {G. C.}",
year = "1987",
language = "English (US)",
volume = "206",
pages = "279--288",
journal = "Annals of Surgery",
issn = "0003-4932",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - 3% NaCl and 7.5% NaCl/dextran 70 in the resuscitation of severely injured patients

AU - Holcroft, James W

AU - Vassar, M. J.

AU - Turner, J. E.

AU - Derlet, R. W.

AU - Kramer, G. C.

PY - 1987

Y1 - 1987

N2 - Cardiovascular resuscitation of the severely injured patient in the field reamins unsatisfactory because large volumes of intravenous fluid are needed to keep up with ongoing blood losses and because only small volumes of fluid can be given. In the first study reported here, small volumes (≤12 mL/kg) of 3% NaCl were given to patients who were having surgery for severe injuries. The 3% NaCl restored blood pressure, pH, and urine output with approximately one half of the cumulative fluid requirement of patients who received isotonic fluids (p < 0.05). In a second study, 7.5% NaCl/dextran 70, 250 mL, was given in a prospective, randomized, and double-blinded trial to injured patients in the field. Blood pressure in the hypertonic/hyperoncotic group increased 49 mmHg during transport (p<0.005); blood pressure in patients given lactated Ringer's solution increased 19 mmHg (NS). Survival favored the hypertonic/hyperoncotic group. The 7.5% of NaCl/dextran 70 solution appears particularly promising for treatment of injured patients in the field

AB - Cardiovascular resuscitation of the severely injured patient in the field reamins unsatisfactory because large volumes of intravenous fluid are needed to keep up with ongoing blood losses and because only small volumes of fluid can be given. In the first study reported here, small volumes (≤12 mL/kg) of 3% NaCl were given to patients who were having surgery for severe injuries. The 3% NaCl restored blood pressure, pH, and urine output with approximately one half of the cumulative fluid requirement of patients who received isotonic fluids (p < 0.05). In a second study, 7.5% NaCl/dextran 70, 250 mL, was given in a prospective, randomized, and double-blinded trial to injured patients in the field. Blood pressure in the hypertonic/hyperoncotic group increased 49 mmHg during transport (p<0.005); blood pressure in patients given lactated Ringer's solution increased 19 mmHg (NS). Survival favored the hypertonic/hyperoncotic group. The 7.5% of NaCl/dextran 70 solution appears particularly promising for treatment of injured patients in the field

UR - http://www.scopus.com/inward/record.url?scp=0023617271&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023617271&partnerID=8YFLogxK

M3 - Article

C2 - 2443087

AN - SCOPUS:0023617271

VL - 206

SP - 279

EP - 288

JO - Annals of Surgery

JF - Annals of Surgery

SN - 0003-4932

IS - 3

ER -