3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors reduce the risk of perioperative stroke and mortality after carotid endarterectomy

Matthew J. McGirt, Bruce A. Perler, Benjamin S. Brooke, Graeme F. Woodworth, Alexander Coon, Shamik Jain, Donald Buck, Glen S. Roseborough, Rafael J. Tamargo, Jennifer Heller, Julie A. Freischlag, George M. Williams, Richard Powell, Enrico Ascher, John Chang, Richard Cambria, Phillip Puckridge, J. Fernandes, Michael Judd

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

Objective: There is increasing evidence that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) reduce cardiovascular and cerebrovascular events through anti-inflammatory, plaque stabilization, and neuroprotective effects independent of lipid lowering. This study was designed to investigate whether statin use reduces the incidence of perioperative stroke and mortality among patients undergoing carotid endarterectomy (CEA). Methods: All patients undergoing CEA from 1994 to 2004 at a large academic medical center were retrospectively reviewed. The independent association of statin use and perioperative morbidity was assessed via multivariate logistic regression analysis. Results: CEA was performed by 13 surgeons on 1566 patients (987 men and 579 women; mean age, 72 ± 10 years), including 1440 (92%) isolated and 126 (8%) combined CEA/coronary artery bypass grafting procedures. The indication for CEA was symptomatic disease in 660 (42%) cases. Six hundred fifty-seven (42%) patients received a statin medication for at least 1 week before surgery. Statin use was associated with a reduction in perioperative strokes (1.2% vs 4.5%; P < .01), transient ischemic attacks (1.5% vs 3.6%; P < .01), all-cause mortality (0.3% vs 2.1%; P < .01), and median (interquartile range) length of hospitalization (2 days [2-5 days] vs 3 days [2-7 days]; P < .05). Adjusting for all demographics and comorbidities in multivariate analysis, statin use independently reduced the odds of stroke threefold (odds ratio [95% confidence interval], 0.35 [0.15-0.85]; P < .05) and death fivefold (odds ratio [95% confidence interval], 0.20 [0.04-0.99]; P < .05). Conclusions: These data suggest that perioperative statin use may reduce the incidence of cerebrovascular events and mortality among patients undergoing CEA.

Original languageEnglish (US)
Pages (from-to)829-836
Number of pages8
JournalJournal of Vascular Surgery
Volume42
Issue number5
DOIs
StatePublished - Nov 2005
Externally publishedYes

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Carotid Endarterectomy
Oxidoreductases
Stroke
Mortality
Odds Ratio
Confidence Intervals
Transient Ischemic Attack
Incidence
Neuroprotective Agents
3-hydroxy-3-methylglutaryl-coenzyme A
Coronary Artery Bypass
Comorbidity
Hospitalization
Anti-Inflammatory Agents
Multivariate Analysis
Logistic Models
Regression Analysis
Demography
Morbidity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors reduce the risk of perioperative stroke and mortality after carotid endarterectomy. / McGirt, Matthew J.; Perler, Bruce A.; Brooke, Benjamin S.; Woodworth, Graeme F.; Coon, Alexander; Jain, Shamik; Buck, Donald; Roseborough, Glen S.; Tamargo, Rafael J.; Heller, Jennifer; Freischlag, Julie A.; Williams, George M.; Powell, Richard; Ascher, Enrico; Chang, John; Cambria, Richard; Puckridge, Phillip; Fernandes, J.; Judd, Michael.

In: Journal of Vascular Surgery, Vol. 42, No. 5, 11.2005, p. 829-836.

Research output: Contribution to journalArticle

McGirt, MJ, Perler, BA, Brooke, BS, Woodworth, GF, Coon, A, Jain, S, Buck, D, Roseborough, GS, Tamargo, RJ, Heller, J, Freischlag, JA, Williams, GM, Powell, R, Ascher, E, Chang, J, Cambria, R, Puckridge, P, Fernandes, J & Judd, M 2005, '3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors reduce the risk of perioperative stroke and mortality after carotid endarterectomy', Journal of Vascular Surgery, vol. 42, no. 5, pp. 829-836. https://doi.org/10.1016/j.jvs.2005.08.039
McGirt, Matthew J. ; Perler, Bruce A. ; Brooke, Benjamin S. ; Woodworth, Graeme F. ; Coon, Alexander ; Jain, Shamik ; Buck, Donald ; Roseborough, Glen S. ; Tamargo, Rafael J. ; Heller, Jennifer ; Freischlag, Julie A. ; Williams, George M. ; Powell, Richard ; Ascher, Enrico ; Chang, John ; Cambria, Richard ; Puckridge, Phillip ; Fernandes, J. ; Judd, Michael. / 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors reduce the risk of perioperative stroke and mortality after carotid endarterectomy. In: Journal of Vascular Surgery. 2005 ; Vol. 42, No. 5. pp. 829-836.
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abstract = "Objective: There is increasing evidence that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) reduce cardiovascular and cerebrovascular events through anti-inflammatory, plaque stabilization, and neuroprotective effects independent of lipid lowering. This study was designed to investigate whether statin use reduces the incidence of perioperative stroke and mortality among patients undergoing carotid endarterectomy (CEA). Methods: All patients undergoing CEA from 1994 to 2004 at a large academic medical center were retrospectively reviewed. The independent association of statin use and perioperative morbidity was assessed via multivariate logistic regression analysis. Results: CEA was performed by 13 surgeons on 1566 patients (987 men and 579 women; mean age, 72 ± 10 years), including 1440 (92{\%}) isolated and 126 (8{\%}) combined CEA/coronary artery bypass grafting procedures. The indication for CEA was symptomatic disease in 660 (42{\%}) cases. Six hundred fifty-seven (42{\%}) patients received a statin medication for at least 1 week before surgery. Statin use was associated with a reduction in perioperative strokes (1.2{\%} vs 4.5{\%}; P < .01), transient ischemic attacks (1.5{\%} vs 3.6{\%}; P < .01), all-cause mortality (0.3{\%} vs 2.1{\%}; P < .01), and median (interquartile range) length of hospitalization (2 days [2-5 days] vs 3 days [2-7 days]; P < .05). Adjusting for all demographics and comorbidities in multivariate analysis, statin use independently reduced the odds of stroke threefold (odds ratio [95{\%} confidence interval], 0.35 [0.15-0.85]; P < .05) and death fivefold (odds ratio [95{\%} confidence interval], 0.20 [0.04-0.99]; P < .05). Conclusions: These data suggest that perioperative statin use may reduce the incidence of cerebrovascular events and mortality among patients undergoing CEA.",
author = "McGirt, {Matthew J.} and Perler, {Bruce A.} and Brooke, {Benjamin S.} and Woodworth, {Graeme F.} and Alexander Coon and Shamik Jain and Donald Buck and Roseborough, {Glen S.} and Tamargo, {Rafael J.} and Jennifer Heller and Freischlag, {Julie A.} and Williams, {George M.} and Richard Powell and Enrico Ascher and John Chang and Richard Cambria and Phillip Puckridge and J. Fernandes and Michael Judd",
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T1 - 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors reduce the risk of perioperative stroke and mortality after carotid endarterectomy

AU - McGirt, Matthew J.

AU - Perler, Bruce A.

AU - Brooke, Benjamin S.

AU - Woodworth, Graeme F.

AU - Coon, Alexander

AU - Jain, Shamik

AU - Buck, Donald

AU - Roseborough, Glen S.

AU - Tamargo, Rafael J.

AU - Heller, Jennifer

AU - Freischlag, Julie A.

AU - Williams, George M.

AU - Powell, Richard

AU - Ascher, Enrico

AU - Chang, John

AU - Cambria, Richard

AU - Puckridge, Phillip

AU - Fernandes, J.

AU - Judd, Michael

PY - 2005/11

Y1 - 2005/11

N2 - Objective: There is increasing evidence that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) reduce cardiovascular and cerebrovascular events through anti-inflammatory, plaque stabilization, and neuroprotective effects independent of lipid lowering. This study was designed to investigate whether statin use reduces the incidence of perioperative stroke and mortality among patients undergoing carotid endarterectomy (CEA). Methods: All patients undergoing CEA from 1994 to 2004 at a large academic medical center were retrospectively reviewed. The independent association of statin use and perioperative morbidity was assessed via multivariate logistic regression analysis. Results: CEA was performed by 13 surgeons on 1566 patients (987 men and 579 women; mean age, 72 ± 10 years), including 1440 (92%) isolated and 126 (8%) combined CEA/coronary artery bypass grafting procedures. The indication for CEA was symptomatic disease in 660 (42%) cases. Six hundred fifty-seven (42%) patients received a statin medication for at least 1 week before surgery. Statin use was associated with a reduction in perioperative strokes (1.2% vs 4.5%; P < .01), transient ischemic attacks (1.5% vs 3.6%; P < .01), all-cause mortality (0.3% vs 2.1%; P < .01), and median (interquartile range) length of hospitalization (2 days [2-5 days] vs 3 days [2-7 days]; P < .05). Adjusting for all demographics and comorbidities in multivariate analysis, statin use independently reduced the odds of stroke threefold (odds ratio [95% confidence interval], 0.35 [0.15-0.85]; P < .05) and death fivefold (odds ratio [95% confidence interval], 0.20 [0.04-0.99]; P < .05). Conclusions: These data suggest that perioperative statin use may reduce the incidence of cerebrovascular events and mortality among patients undergoing CEA.

AB - Objective: There is increasing evidence that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) reduce cardiovascular and cerebrovascular events through anti-inflammatory, plaque stabilization, and neuroprotective effects independent of lipid lowering. This study was designed to investigate whether statin use reduces the incidence of perioperative stroke and mortality among patients undergoing carotid endarterectomy (CEA). Methods: All patients undergoing CEA from 1994 to 2004 at a large academic medical center were retrospectively reviewed. The independent association of statin use and perioperative morbidity was assessed via multivariate logistic regression analysis. Results: CEA was performed by 13 surgeons on 1566 patients (987 men and 579 women; mean age, 72 ± 10 years), including 1440 (92%) isolated and 126 (8%) combined CEA/coronary artery bypass grafting procedures. The indication for CEA was symptomatic disease in 660 (42%) cases. Six hundred fifty-seven (42%) patients received a statin medication for at least 1 week before surgery. Statin use was associated with a reduction in perioperative strokes (1.2% vs 4.5%; P < .01), transient ischemic attacks (1.5% vs 3.6%; P < .01), all-cause mortality (0.3% vs 2.1%; P < .01), and median (interquartile range) length of hospitalization (2 days [2-5 days] vs 3 days [2-7 days]; P < .05). Adjusting for all demographics and comorbidities in multivariate analysis, statin use independently reduced the odds of stroke threefold (odds ratio [95% confidence interval], 0.35 [0.15-0.85]; P < .05) and death fivefold (odds ratio [95% confidence interval], 0.20 [0.04-0.99]; P < .05). Conclusions: These data suggest that perioperative statin use may reduce the incidence of cerebrovascular events and mortality among patients undergoing CEA.

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