3 Homologous chromosome associations and nuclear order in meiotic and mitotically dividing cells of budding yeast

Sean M. Burgess

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

This chapter discusses the relationship between nuclear order and the association of homologous DNA sequences in the budding yeast, Saccharomyces cerevisiae. Homologous chromosomes functionally interact with one another to repair DNA double-strand breaks (DSBs) introduced either environmentally (e.g., by γ-irradiation) or deliberately by the cell (e. g., during meiosis). DNA homology recognition in these instances often involves the (RecA) homolog RAD51 and/or the related gene, DMC1. Evidence for interactions between homologous chromosomes occurring independent of DSB formation and (RecA) homolog function has also been described in meiotic, premeiotic, and mitotically dividing cells of yeast. These interactions presumably depend upon DNA homology but the molecular details of such associations are poorly understood. Both DSB-dependent and -independent homolog associations may be facilitated by the nonrandom organization of chromosomes in the nucleus, including centromere and telomere clustering, which are also discussed.

Original languageEnglish (US)
Pages (from-to)49-90
Number of pages42
JournalAdvances in Genetics
Volume46
StatePublished - 2002

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Saccharomycetales
Chromosomes, Human, Pair 3
Chromosomes
Double-Stranded DNA Breaks
Centromere
DNA
Telomere
Meiosis
Sequence Homology
Cluster Analysis
Saccharomyces cerevisiae
Yeasts
Genes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

3 Homologous chromosome associations and nuclear order in meiotic and mitotically dividing cells of budding yeast. / Burgess, Sean M.

In: Advances in Genetics, Vol. 46, 2002, p. 49-90.

Research output: Contribution to journalArticle

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