22q11.2 microdeletions: Linking DNA structural variation to brain dysfunction and schizophrenia

Maria Karayiorgou, Tony J Simon, Joseph A. Gogos

Research output: Contribution to journalArticle

282 Citations (Scopus)

Abstract

Recent studies are beginning to paint a clear and consistent picture of the impairments in psychological and cognitive competencies that are associated with microdeletions in chromosome 22q11.2. These studies have highlighted a strong link between this genetic lesion and schizophrenia. Parallel studies in humans and animal models are starting to uncover the complex genetic and neural substrates altered by the microdeletion. In addition to offering a deeper understanding of the effects of this genetic lesion, these findings may guide analysis of other copy-number variants associated with cognitive dysfunction and psychiatric disorders.

Original languageEnglish (US)
Pages (from-to)402-416
Number of pages15
JournalNature Reviews Neuroscience
Volume11
Issue number6
DOIs
StatePublished - Jun 2010
Externally publishedYes

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Psychiatry
Schizophrenia
Animal Models
Chromosomes
Psychology
DNA
Brain
Cognitive Dysfunction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

22q11.2 microdeletions : Linking DNA structural variation to brain dysfunction and schizophrenia. / Karayiorgou, Maria; Simon, Tony J; Gogos, Joseph A.

In: Nature Reviews Neuroscience, Vol. 11, No. 6, 06.2010, p. 402-416.

Research output: Contribution to journalArticle

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