2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice

Izabela Kania-Korwel, Christopher D. Barnhart, Marianna Stamou, Kim M. Truong, Mohammed H M E El-Komy, Pamela J Lein, Peter Veng-Pedersen, Hans Joachim Lehmler

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Epidemiological and laboratory studies link polychlorinated biphenyls and their metabolites to adverse neurodevelopmental outcomes. Several neurotoxic PCB congeners are chiral and undergo enantiomeric enrichment in mammalian species, which may modulate PCB developmental neurotoxicity. This study measures levels and enantiomeric enrichment of PCB 95 and its hydroxylated metabolites (OH-PCBs) in adult female C57Bl/6 mice following subchronic exposure to racemic PCB 95. Tissue levels of PCB 95 and OH-PCBs increased with increasing dose. Dose-dependent enantiomeric enrichment of PCB 95 was observed in brain and other tissues. OH-PCBs also displayed enantiomeric enrichment in blood and liver, but were not detected in adipose and brain. In light of data suggesting enantioselective effects of chiral PCBs on molecular targets linked to PCB developmental neurotoxicity, our observations highlight the importance of accounting for PCB and OH-PCB enantiomeric enrichment in the assessment of PCB developmental neurotoxicity.

Original languageEnglish (US)
Pages (from-to)11393-11401
Number of pages9
JournalEnvironmental Science and Technology
Volume46
Issue number20
DOIs
StatePublished - Oct 16 2012

Fingerprint

Polychlorinated Biphenyls
Metabolites
PCB
metabolite
Brain
2,2',3,5',6-pentachlorobiphenyl
Tissue
brain
Liver
Epidemiologic Studies
Blood

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry
  • Medicine(all)

Cite this

Kania-Korwel, I., Barnhart, C. D., Stamou, M., Truong, K. M., El-Komy, M. H. M. E., Lein, P. J., ... Lehmler, H. J. (2012). 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environmental Science and Technology, 46(20), 11393-11401. https://doi.org/10.1021/es302810t

2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. / Kania-Korwel, Izabela; Barnhart, Christopher D.; Stamou, Marianna; Truong, Kim M.; El-Komy, Mohammed H M E; Lein, Pamela J; Veng-Pedersen, Peter; Lehmler, Hans Joachim.

In: Environmental Science and Technology, Vol. 46, No. 20, 16.10.2012, p. 11393-11401.

Research output: Contribution to journalArticle

Kania-Korwel, I, Barnhart, CD, Stamou, M, Truong, KM, El-Komy, MHME, Lein, PJ, Veng-Pedersen, P & Lehmler, HJ 2012, '2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice', Environmental Science and Technology, vol. 46, no. 20, pp. 11393-11401. https://doi.org/10.1021/es302810t
Kania-Korwel, Izabela ; Barnhart, Christopher D. ; Stamou, Marianna ; Truong, Kim M. ; El-Komy, Mohammed H M E ; Lein, Pamela J ; Veng-Pedersen, Peter ; Lehmler, Hans Joachim. / 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. In: Environmental Science and Technology. 2012 ; Vol. 46, No. 20. pp. 11393-11401.
@article{ab7dfbc250cd4a3495dec659c9da7b09,
title = "2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice",
abstract = "Epidemiological and laboratory studies link polychlorinated biphenyls and their metabolites to adverse neurodevelopmental outcomes. Several neurotoxic PCB congeners are chiral and undergo enantiomeric enrichment in mammalian species, which may modulate PCB developmental neurotoxicity. This study measures levels and enantiomeric enrichment of PCB 95 and its hydroxylated metabolites (OH-PCBs) in adult female C57Bl/6 mice following subchronic exposure to racemic PCB 95. Tissue levels of PCB 95 and OH-PCBs increased with increasing dose. Dose-dependent enantiomeric enrichment of PCB 95 was observed in brain and other tissues. OH-PCBs also displayed enantiomeric enrichment in blood and liver, but were not detected in adipose and brain. In light of data suggesting enantioselective effects of chiral PCBs on molecular targets linked to PCB developmental neurotoxicity, our observations highlight the importance of accounting for PCB and OH-PCB enantiomeric enrichment in the assessment of PCB developmental neurotoxicity.",
author = "Izabela Kania-Korwel and Barnhart, {Christopher D.} and Marianna Stamou and Truong, {Kim M.} and El-Komy, {Mohammed H M E} and Lein, {Pamela J} and Peter Veng-Pedersen and Lehmler, {Hans Joachim}",
year = "2012",
month = "10",
day = "16",
doi = "10.1021/es302810t",
language = "English (US)",
volume = "46",
pages = "11393--11401",
journal = "Environmental Science & Technology",
issn = "0013-936X",
publisher = "American Chemical Society",
number = "20",

}

TY - JOUR

T1 - 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice

AU - Kania-Korwel, Izabela

AU - Barnhart, Christopher D.

AU - Stamou, Marianna

AU - Truong, Kim M.

AU - El-Komy, Mohammed H M E

AU - Lein, Pamela J

AU - Veng-Pedersen, Peter

AU - Lehmler, Hans Joachim

PY - 2012/10/16

Y1 - 2012/10/16

N2 - Epidemiological and laboratory studies link polychlorinated biphenyls and their metabolites to adverse neurodevelopmental outcomes. Several neurotoxic PCB congeners are chiral and undergo enantiomeric enrichment in mammalian species, which may modulate PCB developmental neurotoxicity. This study measures levels and enantiomeric enrichment of PCB 95 and its hydroxylated metabolites (OH-PCBs) in adult female C57Bl/6 mice following subchronic exposure to racemic PCB 95. Tissue levels of PCB 95 and OH-PCBs increased with increasing dose. Dose-dependent enantiomeric enrichment of PCB 95 was observed in brain and other tissues. OH-PCBs also displayed enantiomeric enrichment in blood and liver, but were not detected in adipose and brain. In light of data suggesting enantioselective effects of chiral PCBs on molecular targets linked to PCB developmental neurotoxicity, our observations highlight the importance of accounting for PCB and OH-PCB enantiomeric enrichment in the assessment of PCB developmental neurotoxicity.

AB - Epidemiological and laboratory studies link polychlorinated biphenyls and their metabolites to adverse neurodevelopmental outcomes. Several neurotoxic PCB congeners are chiral and undergo enantiomeric enrichment in mammalian species, which may modulate PCB developmental neurotoxicity. This study measures levels and enantiomeric enrichment of PCB 95 and its hydroxylated metabolites (OH-PCBs) in adult female C57Bl/6 mice following subchronic exposure to racemic PCB 95. Tissue levels of PCB 95 and OH-PCBs increased with increasing dose. Dose-dependent enantiomeric enrichment of PCB 95 was observed in brain and other tissues. OH-PCBs also displayed enantiomeric enrichment in blood and liver, but were not detected in adipose and brain. In light of data suggesting enantioselective effects of chiral PCBs on molecular targets linked to PCB developmental neurotoxicity, our observations highlight the importance of accounting for PCB and OH-PCB enantiomeric enrichment in the assessment of PCB developmental neurotoxicity.

UR - http://www.scopus.com/inward/record.url?scp=84870038813&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870038813&partnerID=8YFLogxK

U2 - 10.1021/es302810t

DO - 10.1021/es302810t

M3 - Article

C2 - 22974126

AN - SCOPUS:84870038813

VL - 46

SP - 11393

EP - 11401

JO - Environmental Science & Technology

JF - Environmental Science & Technology

SN - 0013-936X

IS - 20

ER -