Abstract
Epidemiological and laboratory studies link polychlorinated biphenyls and their metabolites to adverse neurodevelopmental outcomes. Several neurotoxic PCB congeners are chiral and undergo enantiomeric enrichment in mammalian species, which may modulate PCB developmental neurotoxicity. This study measures levels and enantiomeric enrichment of PCB 95 and its hydroxylated metabolites (OH-PCBs) in adult female C57Bl/6 mice following subchronic exposure to racemic PCB 95. Tissue levels of PCB 95 and OH-PCBs increased with increasing dose. Dose-dependent enantiomeric enrichment of PCB 95 was observed in brain and other tissues. OH-PCBs also displayed enantiomeric enrichment in blood and liver, but were not detected in adipose and brain. In light of data suggesting enantioselective effects of chiral PCBs on molecular targets linked to PCB developmental neurotoxicity, our observations highlight the importance of accounting for PCB and OH-PCB enantiomeric enrichment in the assessment of PCB developmental neurotoxicity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11393-11401 |
| Number of pages | 9 |
| Journal | Environmental Science and Technology |
| Volume | 46 |
| Issue number | 20 |
| DOIs | |
| State | Published - Oct 16 2012 |
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ASJC Scopus subject areas
- Chemistry(all)
- Environmental Chemistry
- Medicine(all)
Cite this
2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. / Kania-Korwel, Izabela; Barnhart, Christopher D.; Stamou, Marianna; Truong, Kim M.; El-Komy, Mohammed H M E; Lein, Pamela J; Veng-Pedersen, Peter; Lehmler, Hans Joachim.
In: Environmental Science and Technology, Vol. 46, No. 20, 16.10.2012, p. 11393-11401.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice
AU - Kania-Korwel, Izabela
AU - Barnhart, Christopher D.
AU - Stamou, Marianna
AU - Truong, Kim M.
AU - El-Komy, Mohammed H M E
AU - Lein, Pamela J
AU - Veng-Pedersen, Peter
AU - Lehmler, Hans Joachim
PY - 2012/10/16
Y1 - 2012/10/16
N2 - Epidemiological and laboratory studies link polychlorinated biphenyls and their metabolites to adverse neurodevelopmental outcomes. Several neurotoxic PCB congeners are chiral and undergo enantiomeric enrichment in mammalian species, which may modulate PCB developmental neurotoxicity. This study measures levels and enantiomeric enrichment of PCB 95 and its hydroxylated metabolites (OH-PCBs) in adult female C57Bl/6 mice following subchronic exposure to racemic PCB 95. Tissue levels of PCB 95 and OH-PCBs increased with increasing dose. Dose-dependent enantiomeric enrichment of PCB 95 was observed in brain and other tissues. OH-PCBs also displayed enantiomeric enrichment in blood and liver, but were not detected in adipose and brain. In light of data suggesting enantioselective effects of chiral PCBs on molecular targets linked to PCB developmental neurotoxicity, our observations highlight the importance of accounting for PCB and OH-PCB enantiomeric enrichment in the assessment of PCB developmental neurotoxicity.
AB - Epidemiological and laboratory studies link polychlorinated biphenyls and their metabolites to adverse neurodevelopmental outcomes. Several neurotoxic PCB congeners are chiral and undergo enantiomeric enrichment in mammalian species, which may modulate PCB developmental neurotoxicity. This study measures levels and enantiomeric enrichment of PCB 95 and its hydroxylated metabolites (OH-PCBs) in adult female C57Bl/6 mice following subchronic exposure to racemic PCB 95. Tissue levels of PCB 95 and OH-PCBs increased with increasing dose. Dose-dependent enantiomeric enrichment of PCB 95 was observed in brain and other tissues. OH-PCBs also displayed enantiomeric enrichment in blood and liver, but were not detected in adipose and brain. In light of data suggesting enantioselective effects of chiral PCBs on molecular targets linked to PCB developmental neurotoxicity, our observations highlight the importance of accounting for PCB and OH-PCB enantiomeric enrichment in the assessment of PCB developmental neurotoxicity.
UR - http://www.scopus.com/inward/record.url?scp=84870038813&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870038813&partnerID=8YFLogxK
U2 - 10.1021/es302810t
DO - 10.1021/es302810t
M3 - Article
C2 - 22974126
AN - SCOPUS:84870038813
VL - 46
SP - 11393
EP - 11401
JO - Environmental Science & Technology
JF - Environmental Science & Technology
SN - 0013-936X
IS - 20
ER -