2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice

Izabela Kania-Korwel; Christopher D. Barnhart; Marianna Stamou; Kim M. Truong; Mohammed H M E El-Komy; Pamela J Lein; Peter Veng-Pedersen; Hans Joachim Lehmler

doi:10.1021/es302810t

2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice

Izabela Kania-Korwel, Christopher D. Barnhart, Marianna Stamou, Kim M. Truong, Mohammed H M E El-Komy, Pamela J Lein, Peter Veng-Pedersen, Hans Joachim Lehmler

Molecular Biosciences

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Epidemiological and laboratory studies link polychlorinated biphenyls and their metabolites to adverse neurodevelopmental outcomes. Several neurotoxic PCB congeners are chiral and undergo enantiomeric enrichment in mammalian species, which may modulate PCB developmental neurotoxicity. This study measures levels and enantiomeric enrichment of PCB 95 and its hydroxylated metabolites (OH-PCBs) in adult female C57Bl/6 mice following subchronic exposure to racemic PCB 95. Tissue levels of PCB 95 and OH-PCBs increased with increasing dose. Dose-dependent enantiomeric enrichment of PCB 95 was observed in brain and other tissues. OH-PCBs also displayed enantiomeric enrichment in blood and liver, but were not detected in adipose and brain. In light of data suggesting enantioselective effects of chiral PCBs on molecular targets linked to PCB developmental neurotoxicity, our observations highlight the importance of accounting for PCB and OH-PCB enantiomeric enrichment in the assessment of PCB developmental neurotoxicity.

Original language	English (US)
Pages (from-to)	11393-11401
Number of pages	9
Journal	Environmental Science and Technology
Volume	46
Issue number	20
DOIs	https://doi.org/10.1021/es302810t
State	Published - Oct 16 2012

ASJC Scopus subject areas

Chemistry(all)
Environmental Chemistry
Medicine(all)

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2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. / Kania-Korwel, Izabela; Barnhart, Christopher D.; Stamou, Marianna; Truong, Kim M.; El-Komy, Mohammed H M E; Lein, Pamela J; Veng-Pedersen, Peter; Lehmler, Hans Joachim.

In: Environmental Science and Technology, Vol. 46, No. 20, 16.10.2012, p. 11393-11401.

Research output: Contribution to journal › Article › peer-review

Kania-Korwel, Izabela ; Barnhart, Christopher D. ; Stamou, Marianna ; Truong, Kim M. ; El-Komy, Mohammed H M E ; Lein, Pamela J ; Veng-Pedersen, Peter ; Lehmler, Hans Joachim. / 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. In: Environmental Science and Technology. 2012 ; Vol. 46, No. 20. pp. 11393-11401.

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abstract = "Epidemiological and laboratory studies link polychlorinated biphenyls and their metabolites to adverse neurodevelopmental outcomes. Several neurotoxic PCB congeners are chiral and undergo enantiomeric enrichment in mammalian species, which may modulate PCB developmental neurotoxicity. This study measures levels and enantiomeric enrichment of PCB 95 and its hydroxylated metabolites (OH-PCBs) in adult female C57Bl/6 mice following subchronic exposure to racemic PCB 95. Tissue levels of PCB 95 and OH-PCBs increased with increasing dose. Dose-dependent enantiomeric enrichment of PCB 95 was observed in brain and other tissues. OH-PCBs also displayed enantiomeric enrichment in blood and liver, but were not detected in adipose and brain. In light of data suggesting enantioselective effects of chiral PCBs on molecular targets linked to PCB developmental neurotoxicity, our observations highlight the importance of accounting for PCB and OH-PCB enantiomeric enrichment in the assessment of PCB developmental neurotoxicity.",

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AU - Stamou, Marianna

AU - Truong, Kim M.

AU - El-Komy, Mohammed H M E

AU - Lein, Pamela J

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AB - Epidemiological and laboratory studies link polychlorinated biphenyls and their metabolites to adverse neurodevelopmental outcomes. Several neurotoxic PCB congeners are chiral and undergo enantiomeric enrichment in mammalian species, which may modulate PCB developmental neurotoxicity. This study measures levels and enantiomeric enrichment of PCB 95 and its hydroxylated metabolites (OH-PCBs) in adult female C57Bl/6 mice following subchronic exposure to racemic PCB 95. Tissue levels of PCB 95 and OH-PCBs increased with increasing dose. Dose-dependent enantiomeric enrichment of PCB 95 was observed in brain and other tissues. OH-PCBs also displayed enantiomeric enrichment in blood and liver, but were not detected in adipose and brain. In light of data suggesting enantioselective effects of chiral PCBs on molecular targets linked to PCB developmental neurotoxicity, our observations highlight the importance of accounting for PCB and OH-PCB enantiomeric enrichment in the assessment of PCB developmental neurotoxicity.

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