Abstract
Effect of C-phycocyanin (from Spirulina platensis) pretreatment on carbontetrachloride and R-(+)-pulegone-induced hepatotoxicity in rats was studied. Intraperitoneal (i.p.) administration (200 mg/kg) of a single dose of phycocyanin to rats, one or three hours prior to R-(+)-pulegone (250 mg/kg) or carbontetrachloride (0.6 ml/kg) challenge, significantly reduced the hepatotoxicity caused by these chemicals. For instance, serum glutamate pyruvate transaminase (SGPT) activity was almost equal to control values. The losses of microsomal cytochrome P450, glucose-6-phosphatase and aminopyrine-N-demethylase were significantly reduced, suggesting that phycocyanin provides protection to liver enzymes. It was noticed that the level of menthofuran, the proximate toxin of R-(+)-pulegone was nearly 70% more in the urine samples collected from rats treated with R-(+)-pulegone alone than rats treated with the combination of phycocyanin and R-(+)-pulegone. The possible mechanism involved in the hepatoprotection is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 428-431 |
| Number of pages | 4 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 249 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 19 1998 |
| Externally published | Yes |
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Keywords
- A monoterpene ketone
- C-phycocyanin
- Carbon tetrachloride
- Hepatoprotective effect
- Hepatotoxicity
- R-(+)-pulegone
- Spirulina platensis
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
20Hepatoprotective effect of C-phycocyanin : Protection for carbon tetrachloride and R-(+)-pulegone-mediated hepatotoxicty in rats. / Vadiraja, Bhat B.; Gaikwad, Nilesh W.; Madyastha, K. M.
In: Biochemical and Biophysical Research Communications, Vol. 249, No. 2, 19.08.1998, p. 428-431.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 20Hepatoprotective effect of C-phycocyanin
T2 - Protection for carbon tetrachloride and R-(+)-pulegone-mediated hepatotoxicty in rats
AU - Vadiraja, Bhat B.
AU - Gaikwad, Nilesh W.
AU - Madyastha, K. M.
PY - 1998/8/19
Y1 - 1998/8/19
N2 - Effect of C-phycocyanin (from Spirulina platensis) pretreatment on carbontetrachloride and R-(+)-pulegone-induced hepatotoxicity in rats was studied. Intraperitoneal (i.p.) administration (200 mg/kg) of a single dose of phycocyanin to rats, one or three hours prior to R-(+)-pulegone (250 mg/kg) or carbontetrachloride (0.6 ml/kg) challenge, significantly reduced the hepatotoxicity caused by these chemicals. For instance, serum glutamate pyruvate transaminase (SGPT) activity was almost equal to control values. The losses of microsomal cytochrome P450, glucose-6-phosphatase and aminopyrine-N-demethylase were significantly reduced, suggesting that phycocyanin provides protection to liver enzymes. It was noticed that the level of menthofuran, the proximate toxin of R-(+)-pulegone was nearly 70% more in the urine samples collected from rats treated with R-(+)-pulegone alone than rats treated with the combination of phycocyanin and R-(+)-pulegone. The possible mechanism involved in the hepatoprotection is discussed.
AB - Effect of C-phycocyanin (from Spirulina platensis) pretreatment on carbontetrachloride and R-(+)-pulegone-induced hepatotoxicity in rats was studied. Intraperitoneal (i.p.) administration (200 mg/kg) of a single dose of phycocyanin to rats, one or three hours prior to R-(+)-pulegone (250 mg/kg) or carbontetrachloride (0.6 ml/kg) challenge, significantly reduced the hepatotoxicity caused by these chemicals. For instance, serum glutamate pyruvate transaminase (SGPT) activity was almost equal to control values. The losses of microsomal cytochrome P450, glucose-6-phosphatase and aminopyrine-N-demethylase were significantly reduced, suggesting that phycocyanin provides protection to liver enzymes. It was noticed that the level of menthofuran, the proximate toxin of R-(+)-pulegone was nearly 70% more in the urine samples collected from rats treated with R-(+)-pulegone alone than rats treated with the combination of phycocyanin and R-(+)-pulegone. The possible mechanism involved in the hepatoprotection is discussed.
KW - A monoterpene ketone
KW - C-phycocyanin
KW - Carbon tetrachloride
KW - Hepatoprotective effect
KW - Hepatotoxicity
KW - R-(+)-pulegone
KW - Spirulina platensis
UR - http://www.scopus.com/inward/record.url?scp=0032547152&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032547152&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1998.9149
DO - 10.1006/bbrc.1998.9149
M3 - Article
C2 - 9712713
AN - SCOPUS:0032547152
VL - 249
SP - 428
EP - 431
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -