Abstract
Effect of C-phycocyanin (from Spirulina platensis) pretreatment on carbontetrachloride and R-(+)-pulegone-induced hepatotoxicity in rats was studied. Intraperitoneal (i.p.) administration (200 mg/kg) of a single dose of phycocyanin to rats, one or three hours prior to R-(+)-pulegone (250 mg/kg) or carbontetrachloride (0.6 ml/kg) challenge, significantly reduced the hepatotoxicity caused by these chemicals. For instance, serum glutamate pyruvate transaminase (SGPT) activity was almost equal to control values. The losses of microsomal cytochrome P450, glucose-6-phosphatase and aminopyrine-N-demethylase were significantly reduced, suggesting that phycocyanin provides protection to liver enzymes. It was noticed that the level of menthofuran, the proximate toxin of R-(+)-pulegone was nearly 70% more in the urine samples collected from rats treated with R-(+)-pulegone alone than rats treated with the combination of phycocyanin and R-(+)-pulegone. The possible mechanism involved in the hepatoprotection is discussed.
Original language | English (US) |
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Pages (from-to) | 428-431 |
Number of pages | 4 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 249 |
Issue number | 2 |
DOIs | |
State | Published - Aug 19 1998 |
Externally published | Yes |
Keywords
- A monoterpene ketone
- C-phycocyanin
- Carbon tetrachloride
- Hepatoprotective effect
- Hepatotoxicity
- R-(+)-pulegone
- Spirulina platensis
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology