2010 ACVIM Small Animal Consensus Statement on Leptospirosis

Diagnosis, Epidemiology, Treatment, and Prevention

Jane E Sykes, K. Hartmann, K. F. Lunn, G. E. Moore, R. A. Stoddard, R. E. Goldstein

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

This report offers a consensus opinion on the diagnosis, epidemiology, treatment, and prevention of leptospirosis in dogs, an important zoonosis. Clinical signs of leptospirosis in dogs relate to development of renal disease, hepatic disease, uveitis, and pulmonary hemorrhage. Disease may follow periods of high rainfall, and can occur in dogs roaming in proximity to water sources, farm animals, or wildlife, or dogs residing in suburban environments. Diagnosis is based on acute and convalescent phase antibody titers by the microscopic agglutination test (MAT), with or without use of polymerase chain reaction assays. There is considerable interlaboratory variation in MAT results, and the MAT does not accurately predict the infecting serogroup. The recommended treatment for optimal clearance of the organism from renal tubules is doxycycline, 5 mg/kg PO q12h, for 14 days. Annual vaccination can prevent leptospirosis caused by serovars included in the vaccine and is recommended for dogs at risk of infection.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalJournal of Veterinary Internal Medicine
Volume25
Issue number1
DOIs
StatePublished - Jan 2011

Fingerprint

Leptospirosis
leptospirosis
epidemiology
Epidemiology
Agglutination Tests
Dogs
agglutination tests
dogs
animals
serotypes
Kidney
Therapeutics
renal tubules
doxycycline
Doxycycline
Uveitis
Domestic Animals
Zoonoses
liver diseases
zoonoses

Keywords

  • Hepatitis
  • Leptospira interrogans
  • Nephritis
  • Zoonosis

ASJC Scopus subject areas

  • veterinary(all)

Cite this

2010 ACVIM Small Animal Consensus Statement on Leptospirosis : Diagnosis, Epidemiology, Treatment, and Prevention. / Sykes, Jane E; Hartmann, K.; Lunn, K. F.; Moore, G. E.; Stoddard, R. A.; Goldstein, R. E.

In: Journal of Veterinary Internal Medicine, Vol. 25, No. 1, 01.2011, p. 1-13.

Research output: Contribution to journalArticle

Sykes, Jane E ; Hartmann, K. ; Lunn, K. F. ; Moore, G. E. ; Stoddard, R. A. ; Goldstein, R. E. / 2010 ACVIM Small Animal Consensus Statement on Leptospirosis : Diagnosis, Epidemiology, Treatment, and Prevention. In: Journal of Veterinary Internal Medicine. 2011 ; Vol. 25, No. 1. pp. 1-13.
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