2-Polystyrylsulfonamidoethanol: Its improved preparation and application in solid-phase synthesis of hydantoin and isoxazoline

Juntao Luo, Weimin Sun, Wenqiang Huang, Qiang Wu, Xiaoxia Zhu

Research output: Contribution to journalArticle

Abstract

An improved preparation of 2-polystyrylsulfonamidoethanol resin and its primary application as a polymer support in the synthesis of substituted hydantoin and isoxazoline were reported. A solvent-free synthetic procedure for preparation of 2-polystyrylsulfonamidoethanol resin was optimized by the use of a diffuse reflectance IR spectroscopy technique. Polystyrylsulfonyl chloride (1) was reacted with aminoethanol to yield the 2-polysyrylsulfoamidoethanol Resin 2. Resin 2 was then used as a polymer support in solid phase synthesis of 1-phenylhydantoin and 3-m-nitrophenyl-5-carboxylisoxazoline. The results show that 2-polystyrylsulfonamidoethanol resin is a suitable and useful polymer support.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalChemical Journal on Internet
Volume4
Issue number3
StatePublished - Feb 1 2002
Externally publishedYes

Keywords

  • 2-Polystyrylsulfonamidoethanol
  • Hydantoin
  • Isoxazoline
  • Polymer support
  • Solid phase synthesis

ASJC Scopus subject areas

  • Chemistry(all)

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