An improved preparation of 2-polystyrylsulfonamidoethanol resin and its primary application as a polymer support in the synthesis of substituted hydantoin and isoxazoline were reported. A solvent-free synthetic procedure for preparation of 2-polystyrylsulfonamidoethanol resin was optimized by the use of a diffuse reflectance IR spectroscopy technique. Polystyrylsulfonyl chloride (1) was reacted with aminoethanol to yield the 2-polysyrylsulfoamidoethanol Resin 2. Resin 2 was then used as a polymer support in solid phase synthesis of 1-phenylhydantoin and 3-m-nitrophenyl-5-carboxylisoxazoline. The results show that 2-polystyrylsulfonamidoethanol resin is a suitable and useful polymer support.
|Original language||English (US)|
|Number of pages||6|
|Journal||Chemical Journal on Internet|
|State||Published - Feb 1 2002|
- Polymer support
- Solid phase synthesis
ASJC Scopus subject areas