2-Carboxyethylgermanium sesquioxide, a synthetic organogermanium compound, as an inducer of contrasuppressor T cells

K. Ikemoto, M. Kobayashi, T. Fukumoto, M. Morimatsu, Richard B Pollard, F. Suzuki

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

2-Carboxyethylgermanium sesquioxide (Ge-132), a synthesized organogermanium compound with immunomodulaing activities, was shown to be an inducer of anti-suppressor T cells in normal mice. The suppressor cell activity of T6S cells, a clone of burn-induced CD8+ IL-4-producing suppressor T cells, was clearly inhibited when a mixed lymphocyte-tumor cell reaction of the clone was conducted with splenic mononuclear cells from mice treated orally with a 100 mg/kg dose of Ge-132. The activity of anti-suppressor cells was demonstrated in spleens of mice 2 days after treatment with Ge-132 and reached its peak on day 3. The anti-suppressor cells induced by the compound were of a contrasuppressor T cell-linage, because they were characterized as CD4+ CD28+ TCRα/β+ Vicia villosa lectin-adherent T cells. These cells produced IFN-γ but did not produce IL-2, IL-4, IL-6 or IL-10 in their culture fluids. CD4+ anti-suppressor T cells induced by Ge-132 may be different from other subsets of CD4+ T cells because Th1 and Th2 cells generated in our laboratory did not adhere to Vicia villosa lectin-coated petri dishes, and each produced specific cytokines. Th1 cells produced IFN-γ and IL-2 while Th2 cells produce IL-4 and IL-10 in vitro. These results suggest that Ge-132 may be useful as an inducer of contrasuppressor T cells in immunocompromised individuals bearing suppressor T cells. To eliminate suppressor T cells from immunocompromised hosts may result in improved resistance from various opportunistic infections.

Original languageEnglish (US)
Pages (from-to)159-166
Number of pages8
JournalExperientia
Volume52
Issue number2
DOIs
StatePublished - Feb 1996
Externally publishedYes

Keywords

  • Contrasuppressor T cells
  • Organogermanium compound
  • Suppressor T cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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