17β-estradiol attenuates development of angiotensin II-induced aortic abdominal aneurysm in apolipoprotein E-deficient mice

Baby Martin-McNulty, Doris M. Tham, Valdeci Da Cunha, Jerrick J. Ho, Dennis W Wilson, John C Rutledge, Gary G. Deng, Ronald Vergona, Mark E. Sullivan, Yi Xin Wang

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

Objectives - Angiotensin II (Ang II) promotes vascular inflammation, accelerates atherosclerosis, and induces abdominal aortic aneurysm (AAA). These changes were associated with activation of nuclear factor (NF) -κB-mediated induction of proinflammatory genes. The incidence of AAA in this model was higher in male than in female mice, and the vascular effects of estrogen may be associated with anti-inflammatory actions. The present study was undertaken to test the hypothesis that estrogen can attenuate Ang II-induced AAA in apolipoprotein E-deficient mice via its anti-inflammatory mechanism. Methods and Results - Infusion of Ang II (1.44 mg/kg per d for 1 month) induced AAA in 90% of the animals (n = 20) with an expansion of the suprarenal aorta (diameter 1.9±0.14 mm versus <1 mm in normal mice). In mice treated with 17β-estradiol (E2, 0.25-mg subcutaneous pellets), Ang II induced AAA only in 42% of the animals (n=19) with a significant reduction of average diameters of the suprarenal aorta (1.5±0.14 mm). E2 also decreased the expressions of intracellular adhesion molecule-1, vascular cellular adhesion molecule-1, E-selectin, monocyte chemotactic protein-1, and macrophage-colony stimulating factor in the aorta. Conclusions - These data suggest that attenuation of AAA by E2 is associated with inhibition of proinflammatory gene expression.

Original languageEnglish (US)
Pages (from-to)1627-1632
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume23
Issue number9
DOIs
StatePublished - Sep 1 2003

Keywords

  • Aneurysm
  • Estrogen
  • Gene expression
  • PPAR
  • Vascular inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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